Skip to main content

Table 4 Multivariable analysis taking the total FACT-Cog score as an independent variable

From: Clinical and genetic factors associated with anxiety and depression in breast cancer patients: a cross-sectional study

Model 1: Forward linear regression taking the depression score as the dependent variable (without forcing the genetic variables as independent variables)

Variable

UB

SB

p

95% Confidence Interval

Total FACT-Cog

−0.06

−0.32

< 0.001

−0.10

− 0.03

Sleep quality (PSQI score)

0.30

0.30

0.001

0.13

0.47

Fosaprepitant intake (yes vs no*)

−1.82

−0.19

0.026

−3.43

−0.22

*Reference group; Variables entered in Model 1: carboplatin, total Fact-Cog score, ISI score, PSQI score, fosaprepitant, OPRM1.

Model 2: Forward linear regression taking the depression score as the dependent variable (while forcing the genetic variables as independent variables).

Variable

UB

SB

p

95% Confidence Interval

Total FACT-Cog

−0.07

−0.33

0.001

−0.10

−0.03

Sleep quality (PSQI score)

0.33

0.32

0.001

0.14

0.52

Marital status (married vs single*)

−2.53

−0.21

0.029

−4.80

−0.27

Fosaprepitant intake (yes vs no*)

−2.15

−0.22

0.019

−3.94

−0.37

PER2 (AA vs GG*)

4.60

0.19

0.049

0.02

9.18

*Reference group; Variables entered in Model 2: Marital status, carboplatin, total Fact-Cog score, ISI score, PSQI score, fosaprepitant, CLOCK, PER2, CRY2, OPRM1, ABCB1, COMT, DRD2.

Model 3: Forward linear regression taking the anxiety score as the dependent variable (without forcing the genetic variables as independent variables).

Variable

UB

SB

p

95% Confidence Interval

Total FACT-Cog score

−0.07

−0.32

< 0.001

−0.11

− 0.03

Insomnia severity (ISI score)

0.19

0.26

0.003

0.07

0.32

Fosaprepitant intake (yes vs no*)

−2.17

−0.19

0.022

−4.02

−0.31

COMT Met/Met vs (Val/Val + Val/Met)*

1.09

0.17

0.042

0.04

2.14

*Reference group; Variables entered in Model 3: Carboplatin, cyclophosphamide, total Fact-Cog score, ISI score, PSQI score, fosaprepitant, OPRM1, COMT (Met/Met vs Val/Val + Val/Met).

  1. Abbreviations: UB=Unstandardized Beta and SB=Standardized Beta
Back to article page

BMC Cancer

ISSN: 1471-2407

Contact us