Table 1 Demographic and clinicopathological characteristics for initial treatment
Characteristics | Number (%) | Overall survival (%) | p (Log-rank) |
|---|---|---|---|
Sex | |||
 Male | 68(66.0) | 67.6 | 0.046 |
 Female | 35(34.0) | 48.6 | |
Age | |||
  < 60 | 60(58.3) | 60.0 | 0.744 |
  ≥ 60 | 43(41.7) | 60.0 | |
Comorbidity | |||
 Cardiovascular diseases | 20(19.4) | 70.0 | 0.459 |
 Diabetes | 7(6.8) | 57.1 | |
 Others | 4(3.9) | 100.0 | |
 Combinations | 12(11.7) | 66.7 | |
 None | 60(58.3) | 55.0 | |
Site of primary OSCC | |||
 Tongue | 36(35.0) | 61.1 | 0.600 |
 Floor of mouth | 13(12.6) | 76.9 | |
 Bucca | 21(20.4) | 70.0 | |
 Lower gingiva | 21(20.4) | 47.6 | |
 Upper gingiva | 8(7.8) | 62.5 | |
 Hard palate | 4(3.9) | 50.0 | |
Primary T stage | |||
 T1 | 2(2.0) | 100.0 | 0.011 |
 T2 | 27(26.2) | 74.1 | |
 T3 | 48(46.6) | 64.6 | |
 T4 | 26(25.2) | 38.5 | |
Primary N grade | |||
 N0 | 64(62.1) | 62.5 | 0.344 |
 N1 | 19(18.4) | 68.4 | |
 N2 | 10(9.7) | 40.0 | |
 N3 | 10(9.7) | 60.0 | |
Primary stage# | |||
 Early stage | 23(22.3) | 65.2 (56.2) | 0.680 |
 Late stage | 80(77.7) | 60.0 (43.4) | |
DOI of primary OSCC | |||
  > 10 mm | 45(43.7) | 68.9 | 0.092 |
  ≤ 10 mm | 58(56.3) | 55.2 | |
ENE of primary OSCC | |||
 With ENE | 10(9.7) | 61.3 | 0.757 |
 Without ENE | 93(90.3) | 60.0 | |
Primary histological grade | |||
 Well differentiated | 16(15.5) | 68.8 | 0.747 |
 Moderately differentiated | 65(63.1) | 60.0 | |
 Poorly differentiated | 22(21.4) | 59.1 | |
Neck dissection for primary OSCC | |||
 Bilateral neck dissections | 8(7.8) | 65.9 | 0.116 |
 Ipsilateral neck dissection | 51(49.5) | 60.8 | |
 None | 44(42.7) | 37.5 | |
Margin status after primary surgery | |||
 Positive | 80(77.7) | 60.0 | 0.711 |
 Negative | 23(22.3) | 65.2 | |
Number of positive margins* | |||
 1 | 54(67.5) | 63.0 | 0.711 |
 2 | 25(31.3) | 52.0 | |
 3 | 1(1.3) | 100.0 | |
Positive deep margin* | |||
 Yes | 37(46.3) | 56.8 | 0.714 |
 No | 43(53.8) | 62.8 | |
Primary reconstruction | |||
 Primary closure | 18(17.5) | 66.7 | 0.117 |
 Local flap or skin graft | 57(55.3) | 66.7 | |
 Free flap and PMMF | 28(27.2) | 46.4 | |
Neoadjuvant therapy for primary OSCC | |||
 Yes | 14(13.6) | 35.7 | 0.006 |
 No | 89(86.4) | 65.2 | |
Ceased adjuvant therapy after primary surgery | |||
 No adjuvant therapy | 98(95.1) | 60.2 | 0.432 |
 Ceased adjuvant therapy | 5(4.9) | 80.0 | |