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Table 7 Lagged panel regression models

From: Cannabinoid exposure as a major driver of pediatric acute lymphoid Leukaemia rates across the USA: combined geospatial, multiple imputation and causal inference study

Parameters Model
Lagged Variables Parameter Estimate (C.I.) P-Value Adj. R-Squared F dF P
  Interactive Model 2 Lags
  plm (ALL_Rate ~ Cigarettes * Cannabis * AUD + Analgesics + Cocaine + Income + 5_Races)
Cigarettes, 2 AUD 252.85 (183.13, 322.57) 4.94E-12 0.1084 − 21.106 12,429 1
AUD, 2 Cannabis: AUD 98.16 (65.56, 130.76) 7.31E-09     
Cannabis, 2 Cigarettes 60.32 (36.61, 84.04) 9.01E-07     
Analgesics, 2 Cigarettes: Cannabis 24.47 (14.69, 34.25) 1.34E-06     
Cocaine, 2 Income 1.01 (0.57, 1.44) 6.69E-06     
Analgesics 10.02 (5.38, 14.65) 2.81E-05     
Cigarettes: Cannabis: AUD − 372.02 (−515.25, − 228.79) 5.35E-07     
African-American −0.17 (− 0.24, − 0.11) 1.62E-07     
Cigarettes: AUD −933.3 (− 1263.65, − 602.95) 5.36E-08     
Cocaine −18.93 (−25.45, − 12.41) 2.39E-08     
Cannabis −6.95 (− 9.04, −4.86) 2.07E-10     
White −1.7 (−2.15, − 1.24) 9.93E-13     
Interactive Model 4 Lags      
plm (ALL_Rate ~ Cigarettes * Cannabis * AUD + Analgesics + Cocaine + Income + 5_Races)
Cigarettes, 4 Cigarettes: Cannabis: AUD 1080.24 (773.54, 1386.94) 2.3E-11 0.0348 −24.7061 10,363 1
AUD, 4 Cigarettes: AUD 2872.8 (2029.96, 3715.63) 9.0E-11     
Cannabis, 4 Cannabis 18.57 (12.96, 24.18) 2.9E-10     
Analgesics, 4 Hispanic 0.27 (0.15, 0.39) 1.1E-05     
Cocaine, 4 AIAN-American −2.93 (−5.5, − 0.36) 0.0258     
African-American −0.14 (− 0.21, − 0.07) 5.8E-05     
Cigarettes −168.92 (−237.17, −100.67) 1.8E-06     
Cigarettes: Cannabis −65.26 (−89.6, −40.91) 2.5E-07     
AUD − 786.09 (−978.02, −594.16) 1.4E-14     
Cannabis: AUD −291.97 (−363.15, − 220.8) 1.3E-14     
Interactive Model 6 Lags      
plm (ALL_Rate ~ Cigarettes * Cannabis * AUD + Analgesics + Cocaine + Income + 5_Races)
Cigarettes, 6 Cannabis: AUD 334.49 (201.76, 467.22) 1.3E-06 0.0748 −19.0948 12,293 1
AUD, 6 AUD 854.26 (489.45, 1219.07) 6.6E-06     
Cannabis, 6 Asian 0.33 (0.18, 0.47) 2.8E-05     
Analgesics, 6 Cigarettes: Cannabis 84.43 (40.2, 128.65) 0.0002     
Cocaine, 6 Cigarettes 216.5 (90.79, 342.21) 0.0008     
Analgesics 7.94 (1.08, 14.8) 0.0241     
Cigarettes: AUD − 3188.8 (− 4708.15, − 1669.45) 5.1E-05     
Cannabis −23.42 (−34.15, − 12.7) 2.5E-05     
Cigarettes: Cannabis: AUD − 1262.2 (− 1805.43, −718.97) 7.7E-06     
Cocaine −22.47 (−31.69, − 13.25) 2.8E-06     
African-American −0.31 (− 0.41, − 0.2) 5.6E-08     
White −2.14 (− 2.71, −1.58) 1.1E-12     
Interactive Model 8 Lags      
plm (ALL_Rate ~ Cigarettes * Cannabis * AUD + Analgesics + Cocaine + Income + 5_Races)
Cigarettes, 8 Cigarettes: Cannabis: AUD 599.85 (483.48, 716.22) <  2.2E-16 − 0.0014 −21.9419 92,228 1
AUD, 8 Cigarettes: AUD 923.42 (657.01, 1189.82) 9.4E-11     
Cannabis, 8 Cigarettes 59.16 (38.99, 79.32) 2.9E-08     
Analgesics, 8 AIAN-American 9.11 (5.26, 12.95) 5.8E-06     
Cocaine, 8 Asian 0.36 (0.17, 0.54) 0.0002     
African-American −0.21 (− 0.33, − 0.08) 0.0011     
Analgesics −19.12 (−27.41, − 10.82) 1.0E-05     
AUD −225.61 (− 289.34, − 161.88) 4.1E-11     
Cannabis: AUD −142.95 (− 170.37, − 115.54) <  2.2E-16