Table 1 Cohorts summary by PTEN-status for the 3 cohorts used in this study. TCGA cohort included only primary tumor samples with Gistic scores − 2 (PTEN-null) and 0 (PTEN-intact); Health Professional Follow-up Study (all); and Natural History cohort (samples with IHC call available). PTEN-null represents samples with PTEN deletion and PTEN-intact regular primary tumors