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Table 3 Second-line treatments after first recurrence

From: Combination chemoradiotherapy with temozolomide, vincristine, and interferon-β might improve outcomes regardless of O6-methyl-guanine-DNA-methyltransferase (MGMT) promoter methylation status in newly glioblastoma

Treatment Regimen

The Number of Patients N = 42 (%)

Same as protocol of TMZ + IFN-β

26 (61.9)

TMZ + IFN-β + SRS

8 (19.0)

TMZ + IFN-β + SRS + BEV

1 (2.4)

TMZ + IFN-β + SRS + Surgery

3 (7.1)

TMZ + IFN-β + Surgery+BEV

1 (2.4)

TMZ + INF-β + Surgery

1 (2.4)

Subtotal (TMZ + IFN-β)

40 (95.2)

Surgery alone

1 (2.4)

Best supportive care

1 (2.4)

  1. SRS Stereotactic radiosurgery, BEV Bevacizumab