Table 1 Log2FC, p-value, AUC and corresponding 95%CI for each differentially expressed miRNA observed in the tumor size, LN and REC status groups

Tumor size (≥5 cm/< 5 cm)

Log2FC

p-value

AUC

95% CI

miR-1281

− 0.87487

0.0479

0.6833

0.4101 to 0.9565

miR-2117

−1.51124

0.0026

0.875

0.6826 to 1.0000

miR-378c

1.24370

0.0457

0.8083

0.5528 to 1.0000

miR-452-5p

−0.81783

0.0329

0.7000

0.4376 to 0.9624

miR-5196-5p

−1.27827

0.0132

0.7500

0.5050 to 0.9950

miR-519c-3p

−1.27906

0.0187

0.8000

0.5804 to 1.0000

miR-617

−0.82711

0.0402

0.7167

0.4536 to 0.9797

miR-934

1.610418

0.0193

0.8333

0.6295 to 1.0000

LN status

Log2FC

p-value

AUC

95% CI

let-7f-5p

1.308153

0.0345

0.8091

0.6141 to 1.000

miR-1253

−2.23171

0.0436

0.7909

0.5984 to 0.9834

miR-1255b-5p

−1.43984

0.0298

0.8091

0.6201 to 0.9981

miR-1268a

−0.9362

0.0441

0.7682

0.5632 to 0.9732

miR-1268b

0.7279

0.0084

0.8636

0.6882 to 1.000

miR-128-1-5p

−1.49312

0.0254

0.7818

0.5838 to 0.9799

miR-133a-5p

1.097722

0.0369

0.6727

0.4348 to 0.9106

miR-200c-3p

2.602164

0.0187

0.8182

0.6375 to 0.9988

miR-301a-5p

0.583352

0.0212

0.8091

0.6170 to 1.000

miR-3074-3p

−0.85799

0.0301

0.7273

0.4976 to 0.9570

miR-323b-3p

−1.30263

0.0324

0.7636

0.5366 to 0.9907

miR-367-3p

−0.653

0.0438

0.7545

0.5444 to 0.9647

miR-378f

1.143995

0.0356

0.8000

0.6058 to 0.9942

miR-513b-5p

−1.04378

0.0115

0.7864

0.5790 to 0.9938

miR-520d-5p + miR-527 + miR-518a-5p

−1.53273

0.0161

0.8364

0.6645 to 1.000

miR-520f-3p

−1.7368

0.0355

0.7909

0.5852 to 0.9966

miR-548 l

−0.59929

0.0187

0.7909

0.5936 to 0.9882

miR-548q

−1.98804

0.0105

0.7727

0.5600 to 0.9855

miR-580-3p

1.266989

0.0094

0.8045

0.5962 to 1.000

miR-595

−1.17619

0.0070

0.8182

0.6281 to 1.000

miR-873-5p

−0.86919

0.0434

0.7045

0.4769 to 0.9321

REC status

Log2FC

p-value

AUC

95% CI

miR-10a-5p

−0.86382

0.022

0.7905

0.5801 to 1.000

miR-1200

−1.55119

0.0004

0.8571

0.7004 to 1.000

miR-1249-3p

−1.54646

0.0211

0.8286

0.6493 to 1.000

miR-1271-3p

0.962012

0.0108

0.9143

0.7968 to 1.000

miR-130a-3p

−1.45528

0.0144

0.7810

0.5850 to 0.9769

miR-184

−2.01337

0.0005

0.8857

0.7442 to 1.000

miR-18a-5p

−1.2983

0.0226

0.7667

0.5637 to 0.9696

miR-197-3p

1.067639

0.0412

0.7714

0.5689 to 0.9740

miR-208a-3p

−0.94776

0.0372

0.7333

0.5162 to 0.9505

miR-362-5p

−1.31405

0.0486

0.7619

0.5401 to 0.9837

miR-376a-2-5p

−1.07002

0.0055

0.7048

0.4876 to 0.9220

miR-411-5p

1.185286

0.0084

0.7810

0.5876 to 0.9743

miR-449b-5p

−1.76057

0.0003

0.8571

0.6997 to 1.000

miR-4536-3p

−1.25336

0.0292

0.8000

0.6039 to 0.9961

miR-491-5p

−0.97535

0.0373

0.6952

0.4761 to 0.9144

miR-495-5p

−1.18756

0.0291

0.7238

0.5092 to 0.9385

miR-5001-5p

−1.12657

0.0165

0.7905

0.5968 to 0.9841

miR-517c-3p + miR-519a-3p

−1.31722

0.0364

0.6952

0.4759 to 0.9146

miR-518f-3p

1.233145

0.003

0.8286

0.6538 to 1.000

miR-542-3p

−1.47531

0.0253

0.8095

0.6106 to 1.000

miR-548n

1.427446

0.0044

0.8619

0.6799 to 1.000

miR-587

1.032396

0.0112

0.7714

0.5633 to 0.9796

miR-593-3p

1.172516

0.0446

0.8190

0.6257 to 1.000

miR-595

−1.00655

0.0136

0.8381

0.6600 to 1.000

miR-891a-5p

−1.23041

0.0142

0.7619

0.5570 to 0.9668

miR-99b-5p

−1.3409

0.0267

0.8286

0.6574 to 0.9998