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Table 3 Associations between single SNP of ERCC1 and ERCC2 gene and Quality of Life, depression and anxiety (unadjusted and adjusted for Environmental factors)

From: Genetic polymorphisms and haplotypes of ERCC1 and ERCC2 associated with quality of life, depression, and anxiety status among patients with lung cancer

Area

SNP

Gene

Ref/Alt

Model

Beta (95%CI) aor

OR (95%CI)b

P

Bofferoni adjusted

Environmental factors correction

Beta (95%CI) aor

OR (95%CI)b

P

Bofferoni adjusted

C30 Emotional functions

rs11615

ERCC1

G/A

Additive

6.34 (2.09–10.59)

0.004

0.036

6.85 (2.38–11.31)

0.003

0.027

C30 Fatigue

rs11615

ERCC1

G/A

Additive

0.62 (0.39–0.98)

0.041

0.369

LC13 Dysphagia

rs11615

ERCC1

G/A

Additive

0.20 (0.047–0.88)

0.033

0.297

0.18 (0.04–0.87)

0.033

0.297

SAS Anxiety standard score

rs11615

ERCC1

G/A

Additive

−1.94 (−3.66--0.22)

0.028

0.252

−2.06 (−3.85--0.27)

0.025

0.225

C30 Cognitive functions

rs3212986

ERCC1

C/A

Additive

−5.72 (−10.15--1.31)

0.012

0.108

−6.18 (−10.74--1.62)

0.008

0.072

C30 Physical functions

rs3212986

ERCC1

C/A

Additive

−5.43 (−9.68--1.18)

0.013

0.117

−5.98 (−10.40--1.56)

0.008

0.072

C30 Fatigue

rs3212986

ERCC1

C/A

Additive

1.52 (1.02–2.28)

0.042

0.378

LC13 Dysphagia

rs3212986

ERCC1

C/A

Additive

2.31 (1.02–5.22)

0.045

0.405

4.87 (1.43–16.62)

0.011

0.099

SDS depression standard score

rs3212986

ERCC1

C/A

Dominant

3.07 (0.37–5.77)

0.026

0.234

2.96 (0.21–5.71)

0.036

0.324

SAS Anxiety standard score

rs3212986

ERCC1

C/A

Dominant

3.09 (1.00–5.18)

0.004

0.036

3.41 (1.23–5.57)

0.002

0.018

SAS Anxiety State

rs3212986

ERCC1

C/A

Dominant

1.90 (1.06–3.39)

0.030

0.270

2.03 (1.11–3.73)

0.022

0.198

LC13 Pain in other parts

rs762562

ERCC1

A/G

Additive

1.60 (1.02–2.51)

0.042

0.378

1.73 (1.04–2.86)

0.034

0.306

LC13 Chest pain

rs3916874

ERCC2

C/G

Additive

0.48 (0.25–0.93)

0.029

0.261

SAS Anxiety State

rs13181

ERCC2

T/G

Dominant

0.28 (0.095–0.80)

0.018

0.162

0.22 (0.07–0.66)

0.007

0.063

  1. Ref/Alt:Refer to allele (wild-type allele) / mutant allele. Model:Additive model or Dominant model. Covariates refer to environmental factors including:sex, age, occupation, marriage, education, number of children, smoking history, drinking history, medical insurance, pathological types, clinical stages, metastasis, concurrent symptoms, operation history, and chemotherapy. a β and 95% confidence interval (CI) were reported (Linear regression was used for general health condition and functioning domains, anxiety and depression). b odds ratio (OR) and 95% CI were reported (Logistic regression was used for symptoms domains, anxiety and depression)