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Table 3 Associations between single SNP of ERCC1 and ERCC2 gene and Quality of Life, depression and anxiety (unadjusted and adjusted for Environmental factors)

From: Genetic polymorphisms and haplotypes of ERCC1 and ERCC2 associated with quality of life, depression, and anxiety status among patients with lung cancer

Area SNP Gene Ref/Alt Model Beta (95%CI) aor
OR (95%CI)b
P Bofferoni adjusted Environmental factors correction
Beta (95%CI) aor
OR (95%CI)b
P Bofferoni adjusted
C30 Emotional functions rs11615 ERCC1 G/A Additive 6.34 (2.09–10.59) 0.004 0.036 6.85 (2.38–11.31) 0.003 0.027
C30 Fatigue rs11615 ERCC1 G/A Additive 0.62 (0.39–0.98) 0.041 0.369
LC13 Dysphagia rs11615 ERCC1 G/A Additive 0.20 (0.047–0.88) 0.033 0.297 0.18 (0.04–0.87) 0.033 0.297
SAS Anxiety standard score rs11615 ERCC1 G/A Additive −1.94 (−3.66--0.22) 0.028 0.252 −2.06 (−3.85--0.27) 0.025 0.225
C30 Cognitive functions rs3212986 ERCC1 C/A Additive −5.72 (−10.15--1.31) 0.012 0.108 −6.18 (−10.74--1.62) 0.008 0.072
C30 Physical functions rs3212986 ERCC1 C/A Additive −5.43 (−9.68--1.18) 0.013 0.117 −5.98 (−10.40--1.56) 0.008 0.072
C30 Fatigue rs3212986 ERCC1 C/A Additive 1.52 (1.02–2.28) 0.042 0.378
LC13 Dysphagia rs3212986 ERCC1 C/A Additive 2.31 (1.02–5.22) 0.045 0.405 4.87 (1.43–16.62) 0.011 0.099
SDS depression standard score rs3212986 ERCC1 C/A Dominant 3.07 (0.37–5.77) 0.026 0.234 2.96 (0.21–5.71) 0.036 0.324
SAS Anxiety standard score rs3212986 ERCC1 C/A Dominant 3.09 (1.00–5.18) 0.004 0.036 3.41 (1.23–5.57) 0.002 0.018
SAS Anxiety State rs3212986 ERCC1 C/A Dominant 1.90 (1.06–3.39) 0.030 0.270 2.03 (1.11–3.73) 0.022 0.198
LC13 Pain in other parts rs762562 ERCC1 A/G Additive 1.60 (1.02–2.51) 0.042 0.378 1.73 (1.04–2.86) 0.034 0.306
LC13 Chest pain rs3916874 ERCC2 C/G Additive 0.48 (0.25–0.93) 0.029 0.261
SAS Anxiety State rs13181 ERCC2 T/G Dominant 0.28 (0.095–0.80) 0.018 0.162 0.22 (0.07–0.66) 0.007 0.063
  1. Ref/Alt:Refer to allele (wild-type allele) / mutant allele. Model:Additive model or Dominant model. Covariates refer to environmental factors including:sex, age, occupation, marriage, education, number of children, smoking history, drinking history, medical insurance, pathological types, clinical stages, metastasis, concurrent symptoms, operation history, and chemotherapy. a β and 95% confidence interval (CI) were reported (Linear regression was used for general health condition and functioning domains, anxiety and depression). b odds ratio (OR) and 95% CI were reported (Logistic regression was used for symptoms domains, anxiety and depression)