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Table 2 Univariate and multivariate analysis of overall survival and disease-free survival for patients with intrahepatic cholangiocarcinoma after PSM

From: Impact of surgical margin width on long-term outcomes for intrahepatic cholangiocarcinoma: a multicenter study

Characteristic Variables OS DFS  
   Univariate analysis   Multivariate analysis   Univariate analysis   Multivariate analysis   
   HR (95%CI) P value HR (95%CI) P value HR (95%CI) P value HR (95%CI) P value  
Gender Female vs Male 0.72(0.45–1.14) 0.158    0.77(0.51–1.16) 0.217    
Age (y) ≤60 vs > 60 0.92(0.59–1.43) 0.706    0.71(0.48–1.06) 0.098    
HBsAg Negative vs Positive 1.08(0.67–1.75) 0.750    1.08(0.70–1.66) 0.738    
ECOG score ≤2 vs > 2 1.00(0.64–1.55) 0.986    0.80(0.54–1.18) 0.255    
CA19–9 (U/ml) ≤200 vs > 200 1.23(0.71–2.14) 0.458    0.88(0.53–1.47) 0.625    
CEA (ng/ml) ≤5 vs > 5 1.03(0.63–1.67) 0.912    0.91(0.59–1.39) 0.653    
Blood loss (ml) ≤400 vs > 400 1.02(0.61–1.71) 0.947    0.74(0.46–1.19) 0.216    
Transfusion No vs Yes 1.15(0.69–1.90) 0.600    0.61(0.37–1.02) 0.058    
Laparoscopic approach No vs Yes 1.39(0.34–5.70) 0.644    0.74(0.18–3.00) 0.671    
Major hepatectomy No vs Yes 1.34(0.84–2.15) 0.215    1.02(0.69–1.52) 0.920    
Complications No vs Yes 1.06(0.65–1.73) 0.809    0.87(0.56–1.37) 0.562    
Resection margin (cm) ≤1 vs > 1 1.65(1.06–2.58) 0.026 1.60(1.03–2.50) 0.039 1.49(1.01–2.20) 0.046    
Tumor size (cm) ≤5 vs > 5 1.33(0.85–2.08) 0.214    1.15(0.77–1.70) 0.497    
Tumor number Solitary vs Multiple 1.31(0.81–2.12) 0.267    1.14(0.73–1.80) 0.558    
Lymph node invasion No vs Yes 2.03(1.15–3.57) 0.014 2.24(1.27–3.95) 0.005 1.15(0.65–2.02) 0.638    
Mass-forming No vs Yes 1.17(0.73–1.87) 0.524    1.33(0.87–2.05) 0.187    
Tumor differentiation Well &Moderate vs Poor 1.33(0.85–2.08) 0.214    0.80(0.48–1.34) 0.399    
Satellite No vs Yes 1.27(0.77–2.11) 0.352    1.32(0.84–2.09) 0.231    
MVI No vs Yes 2.03(1.12–3.69) 0.02    2.42(1.39–4.22) 0.002 2.67(1.50–4.74) 0.001  
Perineural invasion No vs Yes 0.94(0.50–1.79) 0.860    0.69(0.38–1.26) 0.232    
p-AT No vs Yes 0.38(0.18–0.83) 0.016 0.39(0.18–0.85) 0.018 0.73(0.43–1.24) 0.244    
  1. Abbreviations: PSM propensity score matching, CEA carcinoembryonic antigen, CA19–9 carbohydrate antigen 19–9, HBsAg hepatitis B surface antigen, MVI microvascular invasion, p-AT postoperative adjuvant therapy, OS overall survival, DFS disease-free survival, HR hazard ratio