Table 3 Univariate and multivariate Cox regression analyses LC3 for overall survival and disease-free survival of patients in the cohort
Univariate analysis | Overall survival | Disease-free survival | ||
Hazard ratio (95% CI) | P-value | Hazard ratio (95% CI) | P-value | |
LC3 in tumor (low vs. high) | 3.81 (1.35–10.8) | 0.012 | 5.15 (1.47–17.9) | 0.01 |
Sex (male vs. female) | 0.47 (0.10–2.20) | 0.34 | 4.85 (1.19–19.7) | 0.027 |
Age (≥60 vs. < 60 years) | 2.46 (0.73–8.24) | 0.145 | 2.33 (0.64–8.38) | 0.195 |
Alcohol use (absent vs. present) | 0.43 (0.15–1.20) | 0.108 | 3.64 (0.98–13.1) | 0.053 |
HBV (negative vs. positive) | 3.16 (0.89–11.8) | 0.078 | 0.76 (0.21–2.73) | 0.674 |
HCV (negative vs. positive) | 2.98 (0.37–23.8) | 0.303 | 0.03 (0.01–52.2) | 0.36 |
Cirrhosis (absent vs. present) | 1.68 (0.57–4.99) | 0.349 | 0.20 (0.04–1.02) | 0.054 |
Child-Pugh class A | ||||
Edmondson-Steiner Grades (I-II vs. III-IV) | 0.88 (0.20–3.95) | 0.878 | 3.93 (0.96–16.0) | 0.057 |
Tumor size (< 5 vs. ≥5 cm) | 3.08 (1.19–13.7) | 0.037 | 43.6 (0.18–173) | 0.174 |
Tumor number (single vs. multiple) | 0.33 (1.02–1.33) | 0.039 | 0.04 (0.01–12.9) | 0.547 |
AFP (< 200 vs. ≥200 ng/ml) | 0.32 (0.08–1.22) | 0.095 | 4.32 (0.94–19.6) | 0.059 |
Resection (R0 vs. R1/2) | 1.14 (0.39–3.31) | 0.808 | 3.29 (0.91–11.8) | 0.069 |
Microvascular invasion (absent vs. present) | 0.24 (0.08–0.70) | 0.009 | 1.55 (0.42–5.64) | 0.506 |
Macrovascular invasion (absent vs. present) | 0.53 (0.11–2.61) | 0.44 | 0.37 (0.00–189) | 0.45 |
Lympho nodules metastasis (absent vs. present) | 1.69 (0.46–6.22) | 0.425 | 3.92 (0.96–16.0) | 0.057 |
Distal metastasis (absent vs. present) | ||||
AJCC stage (I-II vs. III-IV) | 1.69 (0.46–6.22) | 0.425 | 3.92 (0.96–16.0) | 0.057 |
BCLC stage (A/B vs. C) | 0.92 (0.30–2.75) | 0.883 | 2.71 (0.67–10.9) | 0.161 |
Recurrence (absent vs. present) | 1.56 (0.47–5.20) | 0.466 | ||
Multivariate analysis | Overall survival | Disease-free survival | ||
Hazard ratio (95% CI) | P-value | Hazard ratio (95% CI) | P-value | |
LC3 in tumor (low vs. high) | 6.74 (1.68–26.9) | 0.007 | 51.3 (2.85–922) | 0.008 |
Tumor number (single vs. multiple) | 0.03 (0.00–0.34) | 0.004 | ||
Microvascular invasion (absent vs. present) | 0.07 (0.01–0.46) | 0.006 | ||
Tumor size (< 5 vs. ≥5 cm) | 3.78 (0.39–36.1) | 0.248 | ||
Sex (male vs. female) | 15.8 (0.77–322) | 0.073 | ||
Cirrhosis (absent vs. present) | 17.9 (1.05–306) | 0.046 | ||
Resection (R0 vs. R1/2) | 0.77 (0.11–5.05) | 0.789 | ||