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Table 3 Univariate and multivariate Cox regression analyses LC3 for overall survival and disease-free survival of patients in the cohort

From: Role of autophagy-related protein in the prognosis of combined hepatocellular carcinoma and cholangiocarcinoma after surgical resection

Univariate analysis Overall survival   Disease-free survival  
  Hazard ratio (95% CI) P-value Hazard ratio (95% CI) P-value
LC3 in tumor (low vs. high) 3.81 (1.35–10.8) 0.012 5.15 (1.47–17.9) 0.01
Sex (male vs. female) 0.47 (0.10–2.20) 0.34 4.85 (1.19–19.7) 0.027
Age (≥60 vs. < 60 years) 2.46 (0.73–8.24) 0.145 2.33 (0.64–8.38) 0.195
Alcohol use (absent vs. present) 0.43 (0.15–1.20) 0.108 3.64 (0.98–13.1) 0.053
HBV (negative vs. positive) 3.16 (0.89–11.8) 0.078 0.76 (0.21–2.73) 0.674
HCV (negative vs. positive) 2.98 (0.37–23.8) 0.303 0.03 (0.01–52.2) 0.36
Cirrhosis (absent vs. present) 1.68 (0.57–4.99) 0.349 0.20 (0.04–1.02) 0.054
Child-Pugh class A
 Edmondson-Steiner Grades (I-II vs. III-IV) 0.88 (0.20–3.95) 0.878 3.93 (0.96–16.0) 0.057
 Tumor size (< 5 vs. ≥5 cm) 3.08 (1.19–13.7) 0.037 43.6 (0.18–173) 0.174
 Tumor number (single vs. multiple) 0.33 (1.02–1.33) 0.039 0.04 (0.01–12.9) 0.547
 AFP (< 200 vs. ≥200 ng/ml) 0.32 (0.08–1.22) 0.095 4.32 (0.94–19.6) 0.059
 Resection (R0 vs. R1/2) 1.14 (0.39–3.31) 0.808 3.29 (0.91–11.8) 0.069
 Microvascular invasion (absent vs. present) 0.24 (0.08–0.70) 0.009 1.55 (0.42–5.64) 0.506
 Macrovascular invasion (absent vs. present) 0.53 (0.11–2.61) 0.44 0.37 (0.00–189) 0.45
 Lympho nodules metastasis (absent vs. present) 1.69 (0.46–6.22) 0.425 3.92 (0.96–16.0) 0.057
Distal metastasis (absent vs. present)
 AJCC stage (I-II vs. III-IV) 1.69 (0.46–6.22) 0.425 3.92 (0.96–16.0) 0.057
 BCLC stage (A/B vs. C) 0.92 (0.30–2.75) 0.883 2.71 (0.67–10.9) 0.161
 Recurrence (absent vs. present) 1.56 (0.47–5.20) 0.466   
Multivariate analysis Overall survival   Disease-free survival  
  Hazard ratio (95% CI) P-value Hazard ratio (95% CI) P-value
LC3 in tumor (low vs. high) 6.74 (1.68–26.9) 0.007 51.3 (2.85–922) 0.008
Tumor number (single vs. multiple) 0.03 (0.00–0.34) 0.004   
Microvascular invasion (absent vs. present) 0.07 (0.01–0.46) 0.006   
Tumor size (< 5 vs. ≥5 cm) 3.78 (0.39–36.1) 0.248   
Sex (male vs. female)    15.8 (0.77–322) 0.073
Cirrhosis (absent vs. present)    17.9 (1.05–306) 0.046
Resection (R0 vs. R1/2)    0.77 (0.11–5.05) 0.789
  1. HR: Hazard ratio; CI: Confidence interval; HBV: Hepatitis B virus; HCV: Hepatitis C virus; INR: International normalize ratio; AFP: Alpha-fetoprotein; AJCC: American Joint Committee on Cancer. BCLC: Barcelona clinic liver cancer