Table 3 Association between the expression of eight m6A RNA methylation modulators and clinical characteristic in patients with PAAD based on the TCGA datasets
| Â | EIF3H | IGF2BP3 | IGF2BP2 | KIAA1429 | METTL3 | LRPPRC | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
down expression | overexpression | down expression | overexpression | down expression | overexpression | down expression | overexpression | down expression | overexpression | down expression | overexpression | |
N | 70 | 70 | 70 | 70 | 70 | 70 | 70 | 70 | 70 | 70 | 70 | 70 |
Age | 64.54 ± 10.77 | 64.53 ± 10.92 | 66.57 ± 9.71 | 62.50 ± 11.51 | 67.46 ± 9.92 | 61.61 ± 10.93 | 65.51 ± 10.68 | 63.56 ± 10.92 | 65.77 ± 10.62 | 63.30 ± 10.93 | 64.66 ± 10.42 | 64.41 ± 11.26 |
P-value | 0.994 | Â | 0.025 | Â | 0.001 | Â | 0.286 | Â | 0.177 | Â | 0.895 | Â |
Gender | ||||||||||||
 female | 33 (47.14%) | 33 (47.14%) | 35 (50.00%) | 31 (44.29%) | 39 (55.71%) | 27 (38.57%) | 27 (38.57%) | 39 (55.71%) | 35 (50.00%) | 31 (44.29%) | 31 (44.29%) | 35 (50.00%) |
 male | 37 (52.86%) | 37 (52.86%) | 35 (50.00%) | 39 (55.71%) | 31 (44.29%) | 43 (61.43%) | 43 (61.43%) | 31 (44.29%) | 35 (50.00%) | 39 (55.71%) | 39 (55.71%) | 35 (50.00%) |
P-value | 1.000 | Â | 0.498 | Â | 0.042 | Â | 0.042 | Â | 0.498 | Â | 0.498 | Â |
Maximum tumor dimension | 3.44 ± 1.03 | 4.04 ± 1.70 | 3.40 ± 0.96 | 4.10 ± 1.74 | 3.37 ± 0.95 | 4.15 ± 1.74 | 3.79 ± 1.57 | 3.71 ± 1.30 | 3.52 ± 1.14 | 3.98 ± 1.68 | 3.49 ± 1.07 | 3.99 ± 1.69 |
P-value | 0.016 | Â | 0.006 | Â | 0.002 | Â | 0.755 | Â | 0.069 | Â | 0.050 | Â |
Stage | ||||||||||||
 StagI (IA + IB) | 6 (8.57%) | 6 (8.57%) | 8 (11.43%) | 4 (5.71%) | 8 (11.43%) | 4 (5.71%) | 4 (5.71%) | 8 (11.43%) | 7 (10.00%) | 5 (7.14%) | 6 (8.57%) | 6 (8.57%) |
 StagII (IIA + IIB) | 62 (88.57%) | 59 (84.29%) | 59 (84.29%) | 62 (88.57%) | 59 (84.29%) | 62 (88.57%) | 62 (88.57%) | 59 (84.29%) | 58 (82.86%) | 63 (90.00%) | 60 (85.71%) | 61 (87.14%) |
 StagIII+IV | 2 (2.86%) | 5 (7.14%) | 3 (4.29%) | 4 (5.71%) | 3 (4.29%) | 4 (5.71%) | 4 (5.71%) | 3 (4.29%) | 5 (7.14%) | 2 (2.86%) | 4 (5.71%) | 3 (4.29%) |
P-value | 0.507 | Â | 0.461 | Â | 0.461 | Â | 0.461 | Â | 0.401 | Â | 0.927 | Â |
Grade | ||||||||||||
 G1 + G2 | 51 (72.86%) | 47 (67.14%) | 51 (72.86%) | 47 (67.14%) | 59 (84.29%) | 39 (55.71%) | 52 (74.29%) | 46 (65.71%) | 52 (74.29%) | 46 (65.71%) | 55 (78.57%) | 43 (61.43%) |
 G3 + G4 | 19 (27.14%) | 23 (32.86%) | 19 (27.14%) | 23 (32.86%) | 11 (15.71%) | 31 (44.29%) | 18 (25.71%) | 24 (34.29%) | 18 (25.71%) | 24 (34.29%) | 15 (21.43%) | 27 (38.57%) |
P-value | 0.461 |  | 0.461 |  | < 0.001 |  | 0.268 |  | 0.268 |  | 0.027 |  |