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Table 3 Association between the expression of eight m6A RNA methylation modulators and clinical characteristic in patients with PAAD based on the TCGA datasets

From: Quantification of m6A RNA methylation modulators pattern was a potential biomarker for prognosis and associated with tumor immune microenvironment of pancreatic adenocarcinoma

  EIF3H IGF2BP3 IGF2BP2 KIAA1429 METTL3 LRPPRC
down expression overexpression down expression overexpression down expression overexpression down expression overexpression down expression overexpression down expression overexpression
N 70 70 70 70 70 70 70 70 70 70 70 70
Age 64.54 ± 10.77 64.53 ± 10.92 66.57 ± 9.71 62.50 ± 11.51 67.46 ± 9.92 61.61 ± 10.93 65.51 ± 10.68 63.56 ± 10.92 65.77 ± 10.62 63.30 ± 10.93 64.66 ± 10.42 64.41 ± 11.26
P-value 0.994   0.025   0.001   0.286   0.177   0.895  
Gender
 female 33 (47.14%) 33 (47.14%) 35 (50.00%) 31 (44.29%) 39 (55.71%) 27 (38.57%) 27 (38.57%) 39 (55.71%) 35 (50.00%) 31 (44.29%) 31 (44.29%) 35 (50.00%)
 male 37 (52.86%) 37 (52.86%) 35 (50.00%) 39 (55.71%) 31 (44.29%) 43 (61.43%) 43 (61.43%) 31 (44.29%) 35 (50.00%) 39 (55.71%) 39 (55.71%) 35 (50.00%)
P-value 1.000   0.498   0.042   0.042   0.498   0.498  
Maximum tumor dimension 3.44 ± 1.03 4.04 ± 1.70 3.40 ± 0.96 4.10 ± 1.74 3.37 ± 0.95 4.15 ± 1.74 3.79 ± 1.57 3.71 ± 1.30 3.52 ± 1.14 3.98 ± 1.68 3.49 ± 1.07 3.99 ± 1.69
P-value 0.016   0.006   0.002   0.755   0.069   0.050  
Stage
 StagI (IA + IB) 6 (8.57%) 6 (8.57%) 8 (11.43%) 4 (5.71%) 8 (11.43%) 4 (5.71%) 4 (5.71%) 8 (11.43%) 7 (10.00%) 5 (7.14%) 6 (8.57%) 6 (8.57%)
 StagII (IIA + IIB) 62 (88.57%) 59 (84.29%) 59 (84.29%) 62 (88.57%) 59 (84.29%) 62 (88.57%) 62 (88.57%) 59 (84.29%) 58 (82.86%) 63 (90.00%) 60 (85.71%) 61 (87.14%)
 StagIII+IV 2 (2.86%) 5 (7.14%) 3 (4.29%) 4 (5.71%) 3 (4.29%) 4 (5.71%) 4 (5.71%) 3 (4.29%) 5 (7.14%) 2 (2.86%) 4 (5.71%) 3 (4.29%)
P-value 0.507   0.461   0.461   0.461   0.401   0.927  
Grade
 G1 + G2 51 (72.86%) 47 (67.14%) 51 (72.86%) 47 (67.14%) 59 (84.29%) 39 (55.71%) 52 (74.29%) 46 (65.71%) 52 (74.29%) 46 (65.71%) 55 (78.57%) 43 (61.43%)
 G3 + G4 19 (27.14%) 23 (32.86%) 19 (27.14%) 23 (32.86%) 11 (15.71%) 31 (44.29%) 18 (25.71%) 24 (34.29%) 18 (25.71%) 24 (34.29%) 15 (21.43%) 27 (38.57%)
P-value 0.461   0.461   < 0.001   0.268   0.268   0.027