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Table 4 Univariable and multivariable analysis for overall survival (OS)

From: Modified FOLFIRINOX versus gemcitabine plus oxaliplatin as first-line chemotherapy for patients with locally advanced or metastatic cholangiocarcinoma: a retrospective comparative study

Variables Univariable analysis Multivariable analysis
HR (95% CI) P value HR (95% CI) P value
Treatment regimen
 mFOLFIRINOX vs Gemox 0.595 (0.312–1.135) 0.099 0.547 (0.264–1.131) 0.103
Age
 >58 vs ≤58 1.089 (0.567–2.092) 0.798   
Sex
 male vs female 0.896 (0.650–1.235) 0.504   
ECOG
 1 vs 0 1.709 (0.883–3.310) 0.112 2.148 (1.028–4.488) 0.042
Primary tumor sites
 Intrahepatic Ref    
 Hilar 1.609 (0.827–3.129) 0.161 2.123 (1.023–4.402) 0.043
 Distal 0.893 (0.207–3.846) 0.879 0.890 (0.199–3.983) 0.878
Disease status
 Metastasis vs Locally advanced 0.939 (0.660–1.335) 0.724   
Liver metastasis 1.393 (0.716–2.710) 0.329   
CA19–9
 >40 vs ≤40 3.198 (1.237–8.266) 0.016 4.972 (1.768–13.980) 0.002
  1. Bold values are statistically significant (p ≤ 0.05)
  2. Ref reference, HR hazard ratio, CI confidence interval, ECOG Eastern Cooperative Oncology Group