|
Cell type
|
Total genes
|
Genes filtered (zeros)
|
Genes filtered (PPC)
|
Differentially transcribed
|
Differentially transcribed in the interface (curated annotation)
|
|---|
|
Total (up/down)
|
Of which cancer genes
|
Of which PC genes
|
Total (up/down)
|
Of which cancer genes, consistent
|
Of which PC genes, consistent
|
|---|
|
Epithelial
|
21,618
|
5408
|
189
|
171 (139/32)
|
45 (26%)
|
29 (64%)
|
80 (67/13)
|
35 (44%)
|
23 (67%)
|
|
Fibroblast
|
21,510
|
7141
|
651
|
267 (156/111)
|
27 (10%)
|
9 (33%)
|
97 (58/39)
|
17 (18%)
|
7 (41%)
|
|
Myeloid
|
22,507
|
13,836
|
2695
|
900 (827/73)
|
56 (6%)
|
11 (20%)
|
261 (238/23)
|
32 (12%)
|
10 (31%)
|
|
T cell
|
21,716
|
8807
|
540
|
288 (195/93)
|
42 (15%)
|
18 (42%)
|
83 (55/28)
|
26 (31%)
|
15 (58%)
|
- PPC posterior predictive check, PC prostate cancer. “Of which” refers to the gene selection relative to the category adjacent on the left. “Interface” refers to cell-surface and secreted protein-coding genes. “Curated” refers to the curated database for cellular-interface genes produced in our study (Supplementary file 2). “Consistent” refers to a consistent direction of transcriptional change according to the curated database. Genes were labelled as “cancer genes” if present in the tier1 COSMIC databasehttps://paperpile.com/c/BQQ95X/zLPNs [46] or labelled as such in our manually curated cell-type-specific database (Supplementary file 2). Genes were labelled as “prostate cancer genes” if present in the tier1 COSMIC prostate cancer database datasethttps://paperpile.com/c/BQQ95X/zLPNs [46] or labelled as such in our manually curated cell-type-specific database (Supplementary file 2)
