Table 3 Significant results of the GO enrichment analysis of DEGs

biological processes

GO:0007588 ~ excretion

7

2.64E-07

NPHS2, CLCNKB, UMOD, ATP6V1B1, ATP6V0A4, KCNJ1, AQP2

GO:0001666 ~ response to hypoxia

11

5.42E-07

CAV1, NOL3, CA9, PLOD2, CXCR4, EGLN3, TLR2, HSD11B2, ABAT, CASP1, ANGPTL4

GO:0090383 ~ phagosome acidification

4

9.87E-04

ATP6V1G3, ATP6V1B1, ATP6V0A4, ATP6V0D2

GO:0033572 ~ transferrin transport

4

0.002115

ATP6V1G3, ATP6V1B1, ATP6V0A4, ATP6V0D2

GO:0008286 ~ insulin receptor signaling pathway

5

0.002575

CAV2, ATP6V1G3, ATP6V1B1, ATP6V0A4, ATP6V0D2

GO:0032755 ~ positive regulation of interleukin-6 production

4

0.004349

P2RX7, TLR2, FCER1G, TLR3

GO:0034220 ~ ion transmembrane transport

7

0.004506

FXYD4, CLCNKB, ATP6V1G3, ATP6V1B1, ATP6V0A4, ATP6V0D2, AQP2

GO:0015695 ~ organic cation transport

3

0.00525

RHCG, SLC7A8, RHBG

GO:0006885 ~ regulation of pH

3

0.005972

RHCG, ATP6V1B1, ATP6V0A4

GO:0090090 ~ negative regulation of canonical Wnt signaling pathway

6

0.006989

CTHRC1, CAV1, SOST, GPC3, SFRP1, PSMB9

GO:0042493 ~ response to drug

8

0.007086

P2RX7, CA9, SFRP1, LGALS1, SLC34A1, HSD11B2, ABAT, NNMT

GO:0008152 ~ metabolic process

6

0.007913

ENPP6, LPCAT1, SUCLG1, MAN1C1, ACSF2, ACAA1

GO:0032092 ~ positive regulation of protein binding

4

0.010136

CTHRC1, CAV1, PLK2, TRIB3

GO:0055074 ~ calcium ion homeostasis

3

0.011171

CAV1, ATP6V1B1, CALB1

GO:0006508 ~ proteolysis

10

0.011293

C1QA, C1QB, GGT6, SFRP1, C3, CTSS, CASP1, PLG, DPEP1, XPNPEP2

GO:0055114 ~ oxidation-reduction process

11

0.011711

ALDH6A1, TYRP1, PLOD2, NDUFA4L2, RRM2, EGLN3, HSD11B2, ALDH4A1, DIO1, DCXR, HPD

GO:0010951 ~ negative regulation of endopeptidase activity

5

0.012067

KNG1, C3, SERPINA5, HRG, CSTA

GO:0050900 ~ leukocyte migration

5

0.012407

SLC16A3, CAV1, SLC7A8, FCER1G, ITGB2

GO:0045880 ~ positive regulation of smoothened signaling pathway

3

0.013221

GPC3, SFRP1, FGF9

GO:0001798 ~ positive regulation of type IIa hypersensitivity

2

0.014597

C3, FCER1G

GO:2000054 ~ negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification

2

0.014597

SOST, SFRP1

GO:0061621 ~ canonical glycolysis

3

0.01542

ENO2, PFKP, HK2

GO:0001503 ~ ossification

4

0.020939

SOST, SLC34A1, ATP6V1B1, ATP6V0A4

GO:0006954 ~ inflammatory response

8

0.021562

KNG1, TNFAIP6, P2RX7, CXCR4, C3, TLR2, TLR3, ITGB2

GO:0050717 ~ positive regulation of interleukin-1 alpha secretion

2

0.021815

P2RX7, CASP1

GO:2000116 ~ regulation of cysteine-type endopeptidase activity

2

0.021815

BIRC3, PSMB9

GO:0070634 ~ transepithelial ammonium transport

2

0.021815

RHCG, RHBG

GO:0019065 ~ receptor-mediated endocytosis of virus by host cell

2

0.021815

CAV2, CAV1

GO:0015991 ~ ATP hydrolysis coupled proton transport

3

0.022874

ATP6V1B1, ATP6V0A4, ATP6V0D2

GO:0051480 ~ regulation of cytosolic calcium ion concentration

3

0.022874

CAV1, PVALB, CALB1

GO:0001525 ~ angiogenesis

6

0.024169

CAV1, FGF9, TGFBI, HRG, FGF1, ANGPTL4

GO:0002931 ~ response to ischemia

3

0.024234

CAV1, NOL3, HK2

GO:0072221 ~ metanephric distal convoluted tubule development

2

0.028982

UMOD, CALB1

GO:0002283 ~ neutrophil activation involved in immune response

2

0.028982

FCER1G, TYROBP

GO:0007162 ~ negative regulation of cell adhesion

3

0.029996

KNG1, TGFBI, HRG

GO:0006955 ~ immune response

8

0.03533

RGS1, TNFSF13B, C3, ENPP3, TLR2, CTSS, FCGR3A, FCGR3B

GO:0070836 ~ caveola assembly

2

0.036096

CAV2, CAV1

GO:0015696 ~ ammonium transport

2

0.036096

RHCG, RHBG

GO:0006873 ~ cellular ion homeostasis

2

0.036096

RHCG, SLC4A1

GO:0019740 ~ nitrogen utilization

2

0.036096

RHCG, RHBG

GO:0010543 ~ regulation of platelet activation

2

0.036096

FCER1G, HRG

GO:0051005 ~ negative regulation of lipoprotein lipase activity

2

0.036096

APOC1, ANGPTL4

GO:0034123 ~ positive regulation of toll-like receptor signaling pathway

2

0.036096

TLR2, TLR3

GO:0031623 ~ receptor internalization

3

0.039536

CAV1, FCER1G, ITGB2

GO:0006094 ~ gluconeogenesis

3

0.041225

ENO2, FBP1, PCK2

GO:0050776 ~ regulation of immune response

5

0.041952

C3, ITGB2, FCGR3A, TREM2, TYROBP

GO:0030514 ~ negative regulation of BMP signaling pathway

3

0.04294

CAV1, SOST, SFRP1

GO:0000187 ~ activation of MAPK activity

4

0.043944

P2RX7, CXCR4, FGF1, DUSP9

GO:0007596 ~ blood coagulation

5

0.046407

P2RX7, SERPINA5, FCER1G, ENTPD1, PLG

GO:0032760 ~ positive regulation of tumor necrosis factor production

3

0.046448

TLR2, FCER1G, TLR3

cell composition

GO:0070062 ~ extracellular exosome

61

4.70E-17

FGF9, SLC7A8, CALB1, AQP2, EFHD1, GPC3, PVALB, CXCR4, PLOD2, SERPINA5, TMEM52B, TGFBI, SLC4A1, FCGR3A, ATP6V0D2, FCGR3B, DPEP1, HPD, KNG1, ALDH6A1, CRYAA, SUCLG1, SLC22A8, PFKP, FBP1, C1QA, C1QB, RHCG, MNDA, ABAT, CSTA, CHL1, SH3GL2, ENPP6, C3, ENPP3, APOC1, ITGB2, UMOD, ATP6V1B1, ENO2, HS6ST2, HRG, SUCNR1, ENTPD1, SLC12A3, LGALS1, PCK2, MAN1C1, PLG, PSMB9, XPNPEP2, AFM, GGT6, SFRP1, NPHS2, SLC13A3, FABP1, ATP6V0A4, IGFBP3, DCXR

GO:0016323 ~ basolateral plasma membrane

12

6.23E-08

CLDN8, CAV1, RHCG, CA9, SLC22A7, SLC22A8, SLC7A8, RHBG, UMOD, SLC4A1, ATP6V1B1, AQP2

GO:0005886 ~ plasma membrane

53

4.79E-06

CLDN8, TLR2, SLC7A8, AQP2, GPC3, CXCR4, TGFBI, SLC4A1, FCGR3A, FCGR3B, DPEP1, KNG1, COL23A1, SLC22A7, SUCLG1, SLC22A8, SLC34A1, TNFSF13B, RHCG, CA9, ATP6V1G3, TREM2, SH3GL2, CHL1, ENPP6, CAV2, CAV1, FXYD4, C3, RHBG, TRIB3, CLCNKB, ITGB2, KCNJ1, ENO2, TMEM30B, FCER1G, HRG, SUCNR1, ENTPD1, TYROBP, SLC12A3, PLG, XPNPEP2, SLC16A3, P2RX7, RGS1, SFRP1, NPHS2, SLC13A3, DIO1, ATP6V0A4, DCXR

GO:0005887 ~ integral component of plasma membrane

25

5.00E-05

CAV2, CAV1, FXYD4, SLC12A3, SLC22A7, ENPP3, SLC22A8, TLR2, RHBG, SLC34A1, SLC7A8, TLR3, CLCNKB, AQP2, SLC16A3, P2RX7, LAPTM5, GPC3, RHCG, NPHS2, FCER1G, SLC13A3, SLC4A1, ENTPD1, TYROBP

GO:0016471 ~ vacuolar proton-transporting V-type ATPase complex

4

7.28E-05

ATP6V1G3, ATP6V1B1, ATP6V0A4, ATP6V0D2

GO:0072562 ~ blood microparticle

8

1.04E-04

KNG1, C1QB, AFM, C3, HRG, SLC4A1, PLG, ANGPTL4

GO:0005578 ~ proteinaceous extracellular matrix

10

1.24E-04

CTHRC1, SOST, GPC3, SFRP1, LGALS1, TGFBI, UMOD, FGF1, CHL1, ANGPTL4

GO:0016324 ~ apical plasma membrane

10

2.30E-04

CAV1, RHCG, SLC12A3, SLC34A1, UMOD, ATP6V1B1, ATP6V0A4, ATP6V0D2, DPEP1, AQP2

GO:0005615 ~ extracellular space

22

4.94E-04

KNG1, CTHRC1, C3, FGF9, LGALS1, HILPDA, CTSS, PLG, TNFAIP6, AFM, GPC3, SOST, TNFSF13B, SFRP1, SERPINA5, TGFBI, ENO2, CSTA, FGF1, IGFBP3, DPEP1, ANGPTL4

GO:0031225 ~ anchored component of membrane

6

0.001254

ENPP6, GPC3, UMOD, FCGR3B, DPEP1, XPNPEP2

GO:0016021 ~ integral component of membrane

53

0.002201

CLDN8, TLR2, SLC7A8, TLR3, AQP2, CXCR4, EVI2A, TMEM52B, SMIM5, SLC4A1, FCGR3A, FCGR3B, COL23A1, SLC22A7, SLC22A8, SLC34A1, DMRT2, HEPACAM2, TNFSF13B, CA9, RHCG, SPAG4, HSD11B2, TREM2, CHL1, NETO2, CAV2, TYRP1, CAV1, TMEM213, ENPP3, RHBG, CLCNKB, UMOD, KCNJ1, SEMA5B, LPCAT1, TMEM30B, FCER1G, HS6ST2, SUCNR1, ENTPD1, MS4A6A, TYROBP, TMEM45A, SLC12A3, NDUFA4L2, HILPDA, GGT6, SFRP1, SLC13A3, DIO1, ATP6V0A4

GO:0043234 ~ protein complex

10

0.002667

CAV2, CAV1, SOST, PVALB, SERPINA5, NPHS2, DDB2, FABP1, PRKCDBP, BIRC3

GO:0005576 ~ extracellular region

22

0.004463

KNG1, ENPP6, FGF9, C3, APOC1, UMOD, CTSS, PLG, C1QA, C1QB, AFM, SOST, TNFSF13B, SFRP1, SERPINA5, TGFBI, HRG, FGF1, TREM2, CASP1, IGFBP3, ANGPTL4

GO:0009986 ~ cell surface

11

0.005205

SFRP1, CXCR4, LGALS1, TLR2, SLC34A1, FCER1G, TLR3, HILPDA, ITGB2, PLG, TYROBP

GO:0002080 ~ acrosomal membrane

3

0.007858

CAV2, CAV1, SERPINA5

GO:0005602 ~ complement component C1 complex

2

0.014107

C1QA, C1QB

GO:0045121 ~ membrane raft

6

0.015662

CAV2, CAV1, NPHS2, TLR2, SLC34A1, BIRC3

GO:0000139 ~ Golgi membrane

10

0.024687

CAV2, CAV1, LPCAT1, ST8SIA4, TLR3, HS6ST2, HEPACAM2, MAN1C1, SH3GL2, HPD

GO:0005581 ~ collagen trimer

4

0.027574

C1QA, CTHRC1, C1QB, COL23A1

GO:0005759 ~ mitochondrial matrix

7

0.028942

PDK1, ALDH6A1, SUCLG1, ALDH4A1, ABAT, PCK2, ACSF2

GO:0005782 ~ peroxisomal matrix

3

0.042028

ACOX2, FABP1, ACAA1

molecular function

GO:0019864 ~ IgG binding

4

6.11E-05

FCER1G, UMOD, FCGR3A, FCGR3B

GO:0008201 ~ heparin binding

7

0.001175

KNG1, SOST, SFRP1, FGF9, SERPINA5, HRG, FGF1

GO:0005102 ~ receptor binding

10

0.001189

KNG1, ACOX2, P2RX7, CAV1, TNFSF13B, C3, HRG, HILPDA, PLG, TYROBP

GO:0030506 ~ ankyrin binding

3

0.009327

RHCG, RHBG, SLC4A1

GO:0001530 ~ lipopolysaccharide binding

3

0.011232

P2RX7, TLR2, TREM2

GO:0043027 ~ cysteine-type endopeptidase inhibitor activity involved in apoptotic process

3

0.012243

NOL3, BIRC3, DPEP1

GO:0015301 ~ anion:anion antiporter activity

3

0.012243

SLC22A7, SLC22A8, SLC4A1

GO:0051117 ~ ATPase binding

4

0.017177

CAV1, FXYD4, ATP6V1G3, ATP6V0A4

GO:0042802 ~ identical protein binding

12

0.022021

CLDN8, CAV1, NOL3, SFRP1, CRYAA, FBP1, ALDH4A1, TLR3, SH3GL2, DCXR, TYROBP, ANGPTL4

GO:0015078 ~ hydrogen ion transmembrane transporter activity

3

0.022995

ATP6V1B1, ATP6V0A4, ATP6V0D2

GO:0004869 ~ cysteine-type endopeptidase inhibitor activity

3

0.025762

KNG1, HRG, CSTA