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Table 3 Significant results of the GO enrichment analysis of DEGs

From: Bioinformatics analysis of C3 and CXCR4 demonstrates their potential as prognostic biomarkers in clear cell renal cell carcinoma (ccRCC)

Function Term Count PValue Genes
biological processes GO:0007588 ~ excretion 7 2.64E-07 NPHS2, CLCNKB, UMOD, ATP6V1B1, ATP6V0A4, KCNJ1, AQP2
GO:0001666 ~ response to hypoxia 11 5.42E-07 CAV1, NOL3, CA9, PLOD2, CXCR4, EGLN3, TLR2, HSD11B2, ABAT, CASP1, ANGPTL4
GO:0090383 ~ phagosome acidification 4 9.87E-04 ATP6V1G3, ATP6V1B1, ATP6V0A4, ATP6V0D2
GO:0033572 ~ transferrin transport 4 0.002115 ATP6V1G3, ATP6V1B1, ATP6V0A4, ATP6V0D2
GO:0008286 ~ insulin receptor signaling pathway 5 0.002575 CAV2, ATP6V1G3, ATP6V1B1, ATP6V0A4, ATP6V0D2
GO:0032755 ~ positive regulation of interleukin-6 production 4 0.004349 P2RX7, TLR2, FCER1G, TLR3
GO:0034220 ~ ion transmembrane transport 7 0.004506 FXYD4, CLCNKB, ATP6V1G3, ATP6V1B1, ATP6V0A4, ATP6V0D2, AQP2
GO:0015695 ~ organic cation transport 3 0.00525 RHCG, SLC7A8, RHBG
GO:0006885 ~ regulation of pH 3 0.005972 RHCG, ATP6V1B1, ATP6V0A4
GO:0090090 ~ negative regulation of canonical Wnt signaling pathway 6 0.006989 CTHRC1, CAV1, SOST, GPC3, SFRP1, PSMB9
GO:0042493 ~ response to drug 8 0.007086 P2RX7, CA9, SFRP1, LGALS1, SLC34A1, HSD11B2, ABAT, NNMT
GO:0008152 ~ metabolic process 6 0.007913 ENPP6, LPCAT1, SUCLG1, MAN1C1, ACSF2, ACAA1
GO:0032092 ~ positive regulation of protein binding 4 0.010136 CTHRC1, CAV1, PLK2, TRIB3
GO:0055074 ~ calcium ion homeostasis 3 0.011171 CAV1, ATP6V1B1, CALB1
GO:0006508 ~ proteolysis 10 0.011293 C1QA, C1QB, GGT6, SFRP1, C3, CTSS, CASP1, PLG, DPEP1, XPNPEP2
GO:0055114 ~ oxidation-reduction process 11 0.011711 ALDH6A1, TYRP1, PLOD2, NDUFA4L2, RRM2, EGLN3, HSD11B2, ALDH4A1, DIO1, DCXR, HPD
GO:0010951 ~ negative regulation of endopeptidase activity 5 0.012067 KNG1, C3, SERPINA5, HRG, CSTA
GO:0050900 ~ leukocyte migration 5 0.012407 SLC16A3, CAV1, SLC7A8, FCER1G, ITGB2
GO:0045880 ~ positive regulation of smoothened signaling pathway 3 0.013221 GPC3, SFRP1, FGF9
GO:0001798 ~ positive regulation of type IIa hypersensitivity 2 0.014597 C3, FCER1G
GO:2000054 ~ negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification 2 0.014597 SOST, SFRP1
GO:0061621 ~ canonical glycolysis 3 0.01542 ENO2, PFKP, HK2
GO:0001503 ~ ossification 4 0.020939 SOST, SLC34A1, ATP6V1B1, ATP6V0A4
GO:0006954 ~ inflammatory response 8 0.021562 KNG1, TNFAIP6, P2RX7, CXCR4, C3, TLR2, TLR3, ITGB2
GO:0050717 ~ positive regulation of interleukin-1 alpha secretion 2 0.021815 P2RX7, CASP1
GO:2000116 ~ regulation of cysteine-type endopeptidase activity 2 0.021815 BIRC3, PSMB9
GO:0070634 ~ transepithelial ammonium transport 2 0.021815 RHCG, RHBG
GO:0019065 ~ receptor-mediated endocytosis of virus by host cell 2 0.021815 CAV2, CAV1
GO:0015991 ~ ATP hydrolysis coupled proton transport 3 0.022874 ATP6V1B1, ATP6V0A4, ATP6V0D2
GO:0051480 ~ regulation of cytosolic calcium ion concentration 3 0.022874 CAV1, PVALB, CALB1
GO:0001525 ~ angiogenesis 6 0.024169 CAV1, FGF9, TGFBI, HRG, FGF1, ANGPTL4
GO:0002931 ~ response to ischemia 3 0.024234 CAV1, NOL3, HK2
GO:0072221 ~ metanephric distal convoluted tubule development 2 0.028982 UMOD, CALB1
GO:0002283 ~ neutrophil activation involved in immune response 2 0.028982 FCER1G, TYROBP
GO:0007162 ~ negative regulation of cell adhesion 3 0.029996 KNG1, TGFBI, HRG
GO:0006955 ~ immune response 8 0.03533 RGS1, TNFSF13B, C3, ENPP3, TLR2, CTSS, FCGR3A, FCGR3B
GO:0070836 ~ caveola assembly 2 0.036096 CAV2, CAV1
GO:0015696 ~ ammonium transport 2 0.036096 RHCG, RHBG
GO:0006873 ~ cellular ion homeostasis 2 0.036096 RHCG, SLC4A1
GO:0019740 ~ nitrogen utilization 2 0.036096 RHCG, RHBG
GO:0010543 ~ regulation of platelet activation 2 0.036096 FCER1G, HRG
GO:0051005 ~ negative regulation of lipoprotein lipase activity 2 0.036096 APOC1, ANGPTL4
GO:0034123 ~ positive regulation of toll-like receptor signaling pathway 2 0.036096 TLR2, TLR3
GO:0031623 ~ receptor internalization 3 0.039536 CAV1, FCER1G, ITGB2
GO:0006094 ~ gluconeogenesis 3 0.041225 ENO2, FBP1, PCK2
GO:0050776 ~ regulation of immune response 5 0.041952 C3, ITGB2, FCGR3A, TREM2, TYROBP
GO:0030514 ~ negative regulation of BMP signaling pathway 3 0.04294 CAV1, SOST, SFRP1
GO:0000187 ~ activation of MAPK activity 4 0.043944 P2RX7, CXCR4, FGF1, DUSP9
GO:0007596 ~ blood coagulation 5 0.046407 P2RX7, SERPINA5, FCER1G, ENTPD1, PLG
GO:0032760 ~ positive regulation of tumor necrosis factor production 3 0.046448 TLR2, FCER1G, TLR3
cell composition GO:0070062 ~ extracellular exosome 61 4.70E-17 FGF9, SLC7A8, CALB1, AQP2, EFHD1, GPC3, PVALB, CXCR4, PLOD2, SERPINA5, TMEM52B, TGFBI, SLC4A1, FCGR3A, ATP6V0D2, FCGR3B, DPEP1, HPD, KNG1, ALDH6A1, CRYAA, SUCLG1, SLC22A8, PFKP, FBP1, C1QA, C1QB, RHCG, MNDA, ABAT, CSTA, CHL1, SH3GL2, ENPP6, C3, ENPP3, APOC1, ITGB2, UMOD, ATP6V1B1, ENO2, HS6ST2, HRG, SUCNR1, ENTPD1, SLC12A3, LGALS1, PCK2, MAN1C1, PLG, PSMB9, XPNPEP2, AFM, GGT6, SFRP1, NPHS2, SLC13A3, FABP1, ATP6V0A4, IGFBP3, DCXR
GO:0016323 ~ basolateral plasma membrane 12 6.23E-08 CLDN8, CAV1, RHCG, CA9, SLC22A7, SLC22A8, SLC7A8, RHBG, UMOD, SLC4A1, ATP6V1B1, AQP2
GO:0005886 ~ plasma membrane 53 4.79E-06 CLDN8, TLR2, SLC7A8, AQP2, GPC3, CXCR4, TGFBI, SLC4A1, FCGR3A, FCGR3B, DPEP1, KNG1, COL23A1, SLC22A7, SUCLG1, SLC22A8, SLC34A1, TNFSF13B, RHCG, CA9, ATP6V1G3, TREM2, SH3GL2, CHL1, ENPP6, CAV2, CAV1, FXYD4, C3, RHBG, TRIB3, CLCNKB, ITGB2, KCNJ1, ENO2, TMEM30B, FCER1G, HRG, SUCNR1, ENTPD1, TYROBP, SLC12A3, PLG, XPNPEP2, SLC16A3, P2RX7, RGS1, SFRP1, NPHS2, SLC13A3, DIO1, ATP6V0A4, DCXR
GO:0005887 ~ integral component of plasma membrane 25 5.00E-05 CAV2, CAV1, FXYD4, SLC12A3, SLC22A7, ENPP3, SLC22A8, TLR2, RHBG, SLC34A1, SLC7A8, TLR3, CLCNKB, AQP2, SLC16A3, P2RX7, LAPTM5, GPC3, RHCG, NPHS2, FCER1G, SLC13A3, SLC4A1, ENTPD1, TYROBP
GO:0016471 ~ vacuolar proton-transporting V-type ATPase complex 4 7.28E-05 ATP6V1G3, ATP6V1B1, ATP6V0A4, ATP6V0D2
GO:0072562 ~ blood microparticle 8 1.04E-04 KNG1, C1QB, AFM, C3, HRG, SLC4A1, PLG, ANGPTL4
GO:0005578 ~ proteinaceous extracellular matrix 10 1.24E-04 CTHRC1, SOST, GPC3, SFRP1, LGALS1, TGFBI, UMOD, FGF1, CHL1, ANGPTL4
GO:0016324 ~ apical plasma membrane 10 2.30E-04 CAV1, RHCG, SLC12A3, SLC34A1, UMOD, ATP6V1B1, ATP6V0A4, ATP6V0D2, DPEP1, AQP2
GO:0005615 ~ extracellular space 22 4.94E-04 KNG1, CTHRC1, C3, FGF9, LGALS1, HILPDA, CTSS, PLG, TNFAIP6, AFM, GPC3, SOST, TNFSF13B, SFRP1, SERPINA5, TGFBI, ENO2, CSTA, FGF1, IGFBP3, DPEP1, ANGPTL4
GO:0031225 ~ anchored component of membrane 6 0.001254 ENPP6, GPC3, UMOD, FCGR3B, DPEP1, XPNPEP2
GO:0016021 ~ integral component of membrane 53 0.002201 CLDN8, TLR2, SLC7A8, TLR3, AQP2, CXCR4, EVI2A, TMEM52B, SMIM5, SLC4A1, FCGR3A, FCGR3B, COL23A1, SLC22A7, SLC22A8, SLC34A1, DMRT2, HEPACAM2, TNFSF13B, CA9, RHCG, SPAG4, HSD11B2, TREM2, CHL1, NETO2, CAV2, TYRP1, CAV1, TMEM213, ENPP3, RHBG, CLCNKB, UMOD, KCNJ1, SEMA5B, LPCAT1, TMEM30B, FCER1G, HS6ST2, SUCNR1, ENTPD1, MS4A6A, TYROBP, TMEM45A, SLC12A3, NDUFA4L2, HILPDA, GGT6, SFRP1, SLC13A3, DIO1, ATP6V0A4
GO:0043234 ~ protein complex 10 0.002667 CAV2, CAV1, SOST, PVALB, SERPINA5, NPHS2, DDB2, FABP1, PRKCDBP, BIRC3
GO:0005576 ~ extracellular region 22 0.004463 KNG1, ENPP6, FGF9, C3, APOC1, UMOD, CTSS, PLG, C1QA, C1QB, AFM, SOST, TNFSF13B, SFRP1, SERPINA5, TGFBI, HRG, FGF1, TREM2, CASP1, IGFBP3, ANGPTL4
GO:0009986 ~ cell surface 11 0.005205 SFRP1, CXCR4, LGALS1, TLR2, SLC34A1, FCER1G, TLR3, HILPDA, ITGB2, PLG, TYROBP
GO:0002080 ~ acrosomal membrane 3 0.007858 CAV2, CAV1, SERPINA5
GO:0005602 ~ complement component C1 complex 2 0.014107 C1QA, C1QB
GO:0045121 ~ membrane raft 6 0.015662 CAV2, CAV1, NPHS2, TLR2, SLC34A1, BIRC3
GO:0000139 ~ Golgi membrane 10 0.024687 CAV2, CAV1, LPCAT1, ST8SIA4, TLR3, HS6ST2, HEPACAM2, MAN1C1, SH3GL2, HPD
GO:0005581 ~ collagen trimer 4 0.027574 C1QA, CTHRC1, C1QB, COL23A1
GO:0005759 ~ mitochondrial matrix 7 0.028942 PDK1, ALDH6A1, SUCLG1, ALDH4A1, ABAT, PCK2, ACSF2
GO:0005782 ~ peroxisomal matrix 3 0.042028 ACOX2, FABP1, ACAA1
molecular function GO:0019864 ~ IgG binding 4 6.11E-05 FCER1G, UMOD, FCGR3A, FCGR3B
GO:0008201 ~ heparin binding 7 0.001175 KNG1, SOST, SFRP1, FGF9, SERPINA5, HRG, FGF1
GO:0005102 ~ receptor binding 10 0.001189 KNG1, ACOX2, P2RX7, CAV1, TNFSF13B, C3, HRG, HILPDA, PLG, TYROBP
GO:0030506 ~ ankyrin binding 3 0.009327 RHCG, RHBG, SLC4A1
GO:0001530 ~ lipopolysaccharide binding 3 0.011232 P2RX7, TLR2, TREM2
GO:0043027 ~ cysteine-type endopeptidase inhibitor activity involved in apoptotic process 3 0.012243 NOL3, BIRC3, DPEP1
GO:0015301 ~ anion:anion antiporter activity 3 0.012243 SLC22A7, SLC22A8, SLC4A1
GO:0051117 ~ ATPase binding 4 0.017177 CAV1, FXYD4, ATP6V1G3, ATP6V0A4
GO:0042802 ~ identical protein binding 12 0.022021 CLDN8, CAV1, NOL3, SFRP1, CRYAA, FBP1, ALDH4A1, TLR3, SH3GL2, DCXR, TYROBP, ANGPTL4
GO:0015078 ~ hydrogen ion transmembrane transporter activity 3 0.022995 ATP6V1B1, ATP6V0A4, ATP6V0D2
GO:0004869 ~ cysteine-type endopeptidase inhibitor activity 3 0.025762 KNG1, HRG, CSTA