Table 2 The genes differentially expressed both in GEO database were identified in ccRCC samples

Upregulated DEGs

EGLN3, CA9, ANGPTL4, IGFBP3, ENO2, NDUFA4L2, SPAG4, HK2, CXCR4, APOC1, NOL3, LAPTM5, LPCAT1, PSMB9, CTSS, TYROBP, NETO2, RRM2, TMEM45A, CAV2, LOC101928916 /// NNMT, TNFAIP6, PFKP, TLR3, LGALS1, MIR6787 /// SLC16A3, C3, COL23A1, C1QA, CSTA, CAV1, ITGB2, SEMA5B, PLOD2, C1QB, TRIB3, MS4A6A, PDK1, BIRC3, DDB2, ENTPD1, TREM2, EVI2A, P2RX7, HILPDA, LOC56901, FBXO16 /// ZNF395, ST8SIA4, CTHRC1, PRKCDBP, ENPP3, ISG20, MNDA, SLC16A3, ZNF395, FCER1G, PLK2, TNFSF13B, FCGR3A /// FCGR3B, RGS1, TLR2, TGFBI, CASP1

Downregulated DEGs

KCNJ1, KNG1, CLCNKB, FGF9, DMRT2, CALB1, RHCG, CLDN8, ATP6V0A4, SFRP1, ATP6V1G3, NPHS2, HS6ST2, ABAT, ATP6V1B1, AQP2, ALDH6A1, DIO1, SLC34A1, ATP6V0D2, RHBG, MAN1C1, FGF1, PVALB, UMOD, GPC3, DPEP1, SERPINA5, XPNPEP2, DCXR, TMEM52B, ACOX2, TMEM213, LPPR1, HEPACAM2, GPR110, TFCP2L1, FXYD4, HRG, GGT6, ERP27, SLC12A3, TYRP1, DUSP9, SH3GL2, SMIM5, SUCLG1, UPP2, SLC4A1, SLC22A8, SLC7A8, HSD11B2, ACAA1, SOST, ENPP6, RP11-999E24.3, ALDH4A1

TCF21, EFHD1, FBP1, HPD, TMEM30B, SLC13A3, SLC22A7, AFM, ACSF2, PCK2, PLG, FABP1, LOC155006, SUCNR1, LINC01187, CRYAA, CHL1