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Table 2 Top 22 Hub Genes with degree > = 5

From: Computational analysis for identification of early diagnostic biomarkers and prognostic biomarkers of liver cancer based on GEO and TCGA databases and studies on pathways and biological functions affecting the survival time of liver cancer

Number

Name

Betweenness

BottleNeck

Closeness

Clustering Coefficient

Degree

DMNC

EcCentricity

EPC

MCC

MNC

Radiality

Stress

1

ESR1

2780.97619

58

38.78333

0.16667

13

0.2036

0.15823

29.27

28

11

8.416

5698

2

SPP1

1519.02063

30

35.65

0.22727

12

0.2545

0.18987

28.52

35

11

8.1723

3920

3

AURKA

967.42857

11

32.02619

0.4

11

0.6415

0.13562

24.93

5045

8

7.8002

1918

4

CXCL12

1415.00476

15

32.73333

0.11111

9

0.2842

0.15823

24.1

11

4

7.9926

2458

5

FOS

617.74127

17

33.3

0.30556

9

0.3207

0.15823

27.17

29

8

8.0311

1918

6

NQO1

1353

11

31.55952

0.17857

8

0.309

0.13562

22.39

12

3

7.8515

2882

7

NUSAP1

146

2

25.78452

0.75

8

0.7683

0.11867

23.93

5041

7

7.0561

338

8

TOP2A

332.07302

3

30.27619

0.78571

8

0.6415

0.13562

24.54

5042

8

7.7361

938

9

UBE2C

146.37619

1

27.25119

0.75

8

0.7683

0.11867

24.36

5041

7

7.2229

264

10

AFP

281.74603

4

30.05

0.33333

7

0.3328

0.15823

26.15

17

6

7.7874

770

11

DCN

303.6

3

28.55

0.28571

7

0.2853

0.15823

24.75

13

6

7.5308

782

12

EGR1

228.02381

3

30.21667

0.42857

7

0.4279

0.15823

25.63

25

6

7.8002

602

13

GMNN

0

1

25.28452

1

7

0.7683

0.11867

24.18

5040

7

7.0433

0

14

PTTG1

0

1

25.28452

1

7

0.7683

0.11867

23.95

5040

7

7.0433

0

15

RRM2

0

1

25.28452

1

7

0.7683

0.11867

23.64

5040

7

7.0433

0

16

SOCS3

631.69841

6

31.05952

0.09524

7

0.3078

0.13562

25.03

7

2

7.8259

1378

17

UBE2T

0

1

25.28452

1

7

0.7683

0.11867

24.05

5040

7

7.0433

0

18

CYP1A2

577

5

29.39286

0.2

6

0.309

0.13562

19.57

7

3

7.7361

822

19

GPC3

44.47619

2

26.7

0.53333

6

0.3804

0.15823

24.62

20

6

7.364

138

20

FOSB

35.46667

1

27.55952

0.7

5

0.4538

0.13562

24.25

18

5

7.5821

166

21

PCK1

570

5

24.21786

0.1

5

0.3078

0.11867

10.7

5

2

7.0176

1074

22

SPARCL1

18.43333

1

26.53333

0.6

5

0.389

0.15823

24.88

14

5

7.3897

62