Table 2 Characteristics of patients with different histological types of appendiceal cancer
Variable | Â | Histological Types | Â | P value | ||||
|---|---|---|---|---|---|---|---|---|
|  | GCC (n = 1087) | MAC (n = 2831) | SRCC (n = 575) | NECs (n = 421) | NETs (n = 1667) | NMAC (n = 1762) | MiNENs (n = 390) |  |
Age | ||||||||
 Mean ± SD | 56.5 ± 13.6 | 59.6 ± 14.2 | 59.8 ± 12.7 | 45.7 ± 17.3 | 44.9 ± 17.8 | 62.8 ± 14.8 | 58.4 ± 12. | < 0.0001 |
 Median (range) | 56 (18–99) | 60 (19–98) | 59 (27–94) | 46 (18–94) | 44 (18–95) | 63 (19–97) | 58 (20–89) |  |
  ≤ 56 | 552 (50.8) | 1181 (41.7) | 243 (42.3) | 300 (71.3) | 1199 (71.9) | 591 (33.5) | 170 (43.6) | < 0.0001 |
  > 56 | 535 (49.2) | 1650 (58.3) | 332 (57.7) | 121 (28.7) | 468 (28.1) | 1171 (66.5) | 220 (56.4) |  |
Gender | ||||||||
 Male | 529 (48.7) | 1272 (44.9) | 238 (41.4) | 156 (37.1) | 642 (38.5) | 912 (51.8) | 198 (50.8) | < 0.0001 |
 Female | 558 (51.3) | 1559 (55.1) | 337 (58.6) | 265 (63) | 1025 (61.5) | 850 (48.2) | 192 (49.2) |  |
Marital status | ||||||||
 Married | 650 (59.8) | 1787 (63.1) | 357 (62.1) | 197 (46.8) | 792 (47.5) | 1041 (59.1) | 243 (62.3) | < 0.0001 |
 Unmarrieda | 386 (35.5) | 946 (33.4) | 194 (33.7) | 182 (43.2) | 769 (46.1) | 655 (37.2) | 130 (33.3) |  |
 Unknown | 51 (4.7) | 98 (3.5) | 24 (4.2) | 42 (10) | 106 (6.4) | 66 (3.8) | 17 (4.4) |  |
Race | ||||||||
 African American | 103 (9.5) | 256 (9) | 55 (9.6) | 34 (8.1) | 135 (8.1) | 236 (13.4) | 35 (9) | < 0.0001 |
 White | 938 (86.3) | 2341 (82.7) | 478 (83.1) | 359 (85.3) | 1447 (86.8) | 1395 (79.2) | 341 (87.4) |  |
 Other | 40 (3.7) | 223 (7.9) | 41 (7.1) | 17 (4) | 60 (3.6) | 122 (6.9) | 12 (3.1) |  |
 Unknown | 6 (0.6) | 11 (0.4) | 1 (0.2) | 11 (2.6) | 25 (1.5) | 9 (0.5) | 2 (0.5) |  |
Region | ||||||||
 West | 467 (43) | 1506 (53.2) | 275 (47.8) | 171 (40.6) | 782 (46.9) | 820 (46.5) | 164 (42.1) | < 0.0001 |
 South | 271 (24.9) | 585 (20.7) | 132 (23) | 110 (26.1) | 417 (25) | 467 (26.5) | 96 (24.6) |  |
 Midwest | 120 (11) | 252 (8.9) | 45 (7.8) | 52 (12.4) | 140 (8.4) | 153 (8.7) | 62 (15.9) |  |
 Northwest | 229 (21.1) | 488 (17.2) | 123 (21.4) | 88 (20.9) | 328 (19.7) | 322 (18.3) | 68 (17.4) |  |
CEA | ||||||||
 Negative | 121 (11.1) | 430 (15.2) | 145 (25.2) | 2 (0.5) | 0 (0) | 348 (19.8) | 80 (20.5) | < 0.0001 |
 Positive | 40 (3.7) | 671 (23.7) | 100 (17.4) | 2 (0.5) | 0 (0) | 254 (14.4) | 30 (7.7) |  |
 Unknown | 926 (85.2) | 1730 (61.1) | 330 (57.4) | 417 (99.1) | 1667 (100) | 1160 (65.8) | 280 (71.8) |  |
Deposit | ||||||||
 Negative | 470 (43.2) | 866 (30.6) | 158 (27.5) | 2 (0.5) | 0 (0) | 564 (32) | 162 (41.5) | < 0.0001 |
 Positive | 21 (1.9) | 176 (6.2) | 82 (14.3) | 2 (0.5) | 0 (0) | 123 (7) | 34 (8.7) |  |
 Unknown | 596 (54.8) | 1789 (63.2) | 335 (58.3) | 417 (99.1) | 1667 (100) | 1075 (61) | 194 (49.7) |  |
Tumor size | ||||||||
  < 2 cm | 383 (35.2) | 260 (9.2) | 44 (7.7) | 277 (65.8) | 1400 (84) | 312 (17.7) | 66 (16.9) | < 0.0001 |
  ≥ 2 cm | 392 (36.1) | 1456 (51.4) | 334 (58.1) | 119 (28.3) | 240 (14.4) | 927 (52.6) | 200 (51.3) |  |
 Unknown | 312 (28.7) | 1115 (39.4) | 197 (34.3) | 25 (5.9) | 27 (1.6) | 523 (29.7) | 124 (31.8) |  |
Harvested lymph nodes | ||||||||
  ≤ 12 | 624 (57.4) | 1589 (56.1) | 282 (49) | 284 (67.5) | 1288 (77.3) | 880 (49.9) | 151 (38.7) | < 0.0001 |
  > 12 | 457 (42) | 1199 (42.4) | 286 (49.7) | 130 (30.9) | 364 (21.8) | 855 (48.5) | 236 (60.5) |  |
 Unknown | 6 (0.6) | 43 (1.5) | 7 (1.2) | 7 (1.7) | 15 (0.9) | 27 (1.5) | 3 (0.8) |  |
T stage | ||||||||
 T1 | 108 (9.9) | 233 (8.2) | 20 (3.5) | 293 (69.6) | 1416 (84.9) | 143 (8.1) | 11 (2.8) | < 0.0001 |
 T2 | 137 (12.6) | 180 (6.4) | 14 (2.4) | 48 (11.4) | 152 (9.1) | 204 (11.6) | 13 (3.3) |  |
 T3 | 649 (59.7) | 783 (27.7) | 188 (32.7) | 48 (11.4) | 80 (4.8) | 723 (41) | 209 (53.6) |  |
 T4 | 193 (17.8) | 1635 (57.8) | 353 (61.4) | 32 (7.6) | 19 (1.1) | 692 (39.3) | 157 (40.3) |  |
N stage | ||||||||
 N0 | 950 (87.4) | 2387 (84.3) | 289 (50.3) | 337 (80.1) | 1534 (92) | 1236 (70.2) | 251 (64.4) | < 0.0001 |
 N1 | 91 (8.4) | 291 (10.3) | 136 (23.7) | 72 (17.1) | 128 (7.7) | 312 (17.7) | 66 (16.9) |  |
 N2 | 46 (4.2) | 153 (5.4) | 150 (26.1) | 12 (2.9) | 5 (0.3) | 214 (12.2) | 73 (18.7) |  |
M stage | ||||||||
 M0 | 1003 (92.3) | 1608 (56.8) | 285 (49.6) | 397 (94.3) | 1646 (98.7) | 1377 (78.2) | 288 (73.9) | < 0.0001 |
 M1 | 84 (7.7) | 1223 (43.2) | 290 (50.4) | 24 (5.7) | 21 (1.3) | 385 (21.9) | 102 (26.2) |  |
Grade | ||||||||
 Well differentiated | 165 (15.2) | 1054 (37.2) | 11 (1.9) | 304 (72.2) | 1201 (72.1) | 244 (13.9) | 36 (9.2) | < 0.0001 |
 Moderately differentiated | 142 (13.1) | 973 (34.4) | 35 (6.1) | 50 (11.9) | 136 (8.2) | 928 (52.7) | 56 (14.4) |  |
 Poorly or un-differentiated | 88 (8.1) | 296 (10.5) | 381 (66.3) | 31 (7.4) | 9 (0.5) | 441 (25) | 157 (40.3) |  |
 Unknown | 692 (63.7) | 508 (17.9) | 148 (25.7) | 36 (8.6) | 321 (19.3) | 149 (8.5) | 141 (36.2) |  |
Surgery | ||||||||
 Less than hemicolectomy | 489 (45) | 983 (34.7) | 167 (29) | 246 (58.4) | 1216 (73) | 619 (35.1) | 127 (32.6) | < 0.0001 |
 Hemicolectomy or more | 561 (51.6) | 1631 (57.6) | 366 (63.7) | 151 (35.9) | 380 (22.8) | 1064 (60.4) | 253 (64.9) |  |
 Other | 37 (3.4) | 217 (7.7) | 42 (7.3) | 24 (5.7) | 71 (4.3) | 79 (4.5) | 10 (2.6) |  |
Chemotherapy | ||||||||
 No | 927 (85.3) | 1518 (53.6) | 207 (36) | 400 (95) | 1640 (98.4) | 1046 (59.4) | 219 (56.2) | < 0.0001 |
 Yes | 160 (14.7) | 1313 (46.4) | 368 (64) | 21 (5) | 27 (1.6) | 716 (40.6) | 171 (43.9) |  |
Cancer specific death | ||||||||
 No | 968 (89.1) | 2135 (75.4) | 313 (54.4) | 403 (95.7) | 1656 (99.3) | 1259 (71.5) | 290 (74.4) | < 0.0001 |
 Yes | 119 (11) | 696 (24.6) | 262 (45.6) | 18 (4.3) | 11 (0.7) | 503 (28.6) | 100 (25.6) |  |
Overall death | ||||||||
 No | 837 (77) | 1779 (62.8) | 221 (38.4) | 372 (88.4) | 1605 (96.3) | 930 (52.8) | 256 (65.6) | < 0.0001 |
 Yes | 250 (23) | 1052 (37.2) | 354 (61.6) | 49 (11.6) | 62 (3.7) | 832 (47.2) | 134 (34.4) |  |