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Table 2 Multivariable Cox proportional hazard regression for HCC with and without other cancers included as competing risks in the training cohort

From: Prediction of the risk of developing hepatocellular carcinoma in health screening examinees: a Korean cohort study

 

No competing risk

Competing risk included

 

HR

95% CI

p-value

HR

95% CI

p-value

Agea

1.581

1.540–1.629

< 0.001

1.542

1.493–1.581

< 0.001

Male sex (vs. female)

3.122

2.786–3.496

< 0.001

3.040

2.710–3.401

< 0.001

Family history of chronic liver disease

2.490

2.143–2.893

< 0.001

2.487

2.099–2.948

< 0.001

ALTa

1.049

1.044–1.054

< 0.001

1.048

1.036–1.061

< 0.001

GGTa

1.030

1.027–1.032

< 0.001

1.029

1.026–1.032

< 0.001

Total cholesterola

0.897

0.886–0.908

< 0.001

0.898

0.887–0.910

< 0.001

Chronic liver disease

3.430

3.096–3.800

< 0.001

3.470

3.116–3.863

< 0.001

Chronic hepatitis virus infection

1.851

1.605–2.135

< 0.001

1.862

1.567–2.213

< 0.001

HIV infection

4.097

3.691–4.546

< 0.001

4.057

3.640–4.522

< 0.001

Diabetes mellitus

1.427

1.257–1.619

< 0.001

1.430

1.255–1.629

< 0.001

Dyslipidemia

0.479

0.382–0.601

< 0.001

0.458

0.359–0.585

< 0.001

Schizophrenic or delusional disorders, or mental disorders due to psychoactive substance use

0.655

0.575–0.747

< 0.001

0.645

0.563–0.738

< 0.001

Overweight (vs. normal)

1.182

1.080–1.294

< 0.001

1.190

1.084–1.308

< 0.001

Obese (vs. normal)

1.648

1.297–2.094

< 0.001

1.662

1.304–2.118

< 0.001

Middle income (vs. low)

0.926

0.836–1.025

0.138

0.925

0.831–1.030

0.150

High income (vs. low)

0.832

0.749–0.925

< 0.001

0.834

0.747–0.931

0.001

  1. HCC hepatocellular carcinoma, HR hazard ratio, CI confidence interval, ALT alanine aminotransferase, GGT gamma-glutamyl transferase, HIV human immunodeficiency
  2. aper increment of 10 years, IU/L, or mg/dL