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Table 7 Efficacies of serum AFP testing at different cutoff value in diagnosing early HCC

From: Serum epidermal growth factor-like domain 7 serves as a novel diagnostic marker for early hepatocellular carcinoma

Group

Accuracy

Sensitivity

Specificity

Early HCC vs. healthy individuals

 Serum AFP

  Cut-off value: 20.0 ng/mL

83.8%

65.3%

97.2%

  Cut-off value: 100.0 ng/mL

89.1%

55.1%

100%

  Cut-off value: 400.0 ng/mL

85.1%

38.4%

100%

Early HCC vs. chronic liver disease

 Serum AFP

  Cut-off value: 20.0 ng/mL

61.9%

61.8%

62%

  Cut-off value: 100.0 ng/mL

65.9%

55.1%

78.3%

  Cut-off value: 400.0 ng/mL

62.8%

38.4%

90.8%

  1. HCC Hepatocellular carcinoma, AFP α-fetoprotein, Parallel combined Egf17 and AFP