Table 1 Demographic and tumor characteristics of lung cancer patients with brain metastases
Variable | All subjects | [cases (%)] | Training cohort | [cases (%)] | Validation cohort | [cases (%)] |
|---|---|---|---|---|---|---|
Total | 29,902 | 26,272 | 3630 | |||
Gender | ||||||
Male | 15,596 | 52.2 | 13,741 | 52.3 | 1855 | 51.1 |
Female | 14,306 | 47.8 | 12,531 | 47.7 | 1775 | 48.9 |
Age | ||||||
< 40 | 252 | 0.8 | 212 | 0.8 | 40 | 1.1 |
40–49 | 1648 | 5.5 | 1479 | 5.6 | 169 | 4.7 |
50–59 | 7149 | 23.9 | 6308 | 24.0 | 841 | 23.2 |
60–69 | 10,447 | 34.9 | 9150 | 34.8 | 1297 | 35.7 |
70–79 | 7751 | 25.9 | 6775 | 25.8 | 976 | 26.9 |
> =80 | 2655 | 8.9 | 2348 | 8.9 | 307 | 8.5 |
Race | ||||||
White | 23,759 | 79.5 | 20,947 | 79.7 | 2812 | 77.5 |
Black | 3643 | 12.2 | 3190 | 12.1 | 453 | 12.5 |
Other | 2500 | 8.4 | 2135 | 8.1 | 365 | 10.1 |
Histology | ||||||
AD | 15,427 | 51.6 | 13,467 | 51.3 | 1960 | 54.0 |
SQCC | 3164 | 10.6 | 2770 | 10.5 | 394 | 10.9 |
LCLC | 675 | 2.3 | 601 | 2.3 | 74 | 2.0 |
SCLC | 5087 | 17.0 | 4480 | 17.1 | 607 | 16.7 |
Other | 5547 | 18.6 | 4952 | 18.8 | 595 | 16.4 |
Gleason grade | ||||||
I | 463 | 1.5 | 409 | 1.6 | 54 | 1.5 |
II | 2677 | 9.0 | 2398 | 9.1 | 279 | 7.7 |
III | 7821 | 26.2 | 6927 | 26.4 | 894 | 24.6 |
IV | 1046 | 3.5 | 954 | 3.6 | 92 | 2.5 |
Unknown | 17,895 | 59.8 | 15,584 | 59.3 | 2311 | 63.7 |
T Stage | ||||||
T0 | 292 | 1.0 | 266 | 1.0 | 26 | 0.7 |
T1 | 3244 | 10.8 | 2803 | 10.7 | 441 | 12.1 |
T2 | 7386 | 24.7 | 6441 | 24.5 | 945 | 26.0 |
T3 | 6534 | 21.9 | 5826 | 22.2 | 708 | 19.5 |
T4 | 8802 | 29.4 | 7674 | 29.2 | 1128 | 31.1 |
Tx | 3644 | 12.2 | 3262 | 12.4 | 382 | 10.5 |
N Stage | ||||||
N0 | 6446 | 21.6 | 5675 | 21.6 | 771 | 21.2 |
N1 | 2531 | 8.5 | 2213 | 8.4 | 318 | 8.8 |
N2 | 13,441 | 45.0 | 11,892 | 45.4 | 1549 | 42.7 |
N3 | 5773 | 19.3 | 4994 | 19.0 | 779 | 21.5 |
Nx | 1711 | 5.7 | 1498 | 5.7 | 213 | 5.9 |
Bone Met | ||||||
Yes | 10,024 | 33.5 | 8750 | 33.3 | 1274 | 35.1 |
None | 19,306 | 64.6 | 17,006 | 64.7 | 2300 | 63.4 |
Unknown | 572 | 1.9 | 516 | 2.0 | 56 | 1.5 |
Liver Met | ||||||
Yes | 6189 | 20.7 | 5390 | 20.5 | 799 | 22.0 |
None | 22,971 | 76.8 | 20,226 | 77.0 | 2745 | 75.6 |
Unknown | 742 | 2.5 | 656 | 2.5 | 86 | 2.4 |
Surgery | ||||||
Yes | 961 | 3.2 | 858 | 3.3 | 103 | 2.8 |
None/ Unknown | 28,941 | 96.8 | 25,414 | 96.7 | 3527 | 97.2 |
Chemotherapy | ||||||
Yes | 16,767 | 56.1 | 14,762 | 56.2 | 2005 | 55.2 |
None/ Unknown | 13,135 | 43.9 | 11,510 | 43.8 | 1625 | 44.8 |
Radiotherapy | ||||||
Yes | 6307 | 21.1 | 5497 | 20.9 | 810 | 22.3 |
None/ Unknown | 23,595 | 78.9 | 20,775 | 79.1 | 2820 | 77.7 |
Insurance | ||||||
Yes | 28,191 | 94.3 | 24,723 | 94.1 | 3468 | 95.5 |
None | 1221 | 4.1 | 1128 | 4.3 | 93 | 2.6 |
Unknown | 490 | 1.6 | 421 | 1.6 | 69 | 1.9 |
Marital | ||||||
Single | 13,326 | 44.6 | 11,643 | 44.3 | 1683 | 46.4 |
Married | 15,424 | 51.6 | 13,608 | 51.8 | 1816 | 50.0 |
Unknown | 1152 | 3.9 | 1021 | 3.9 | 131 | 3.6 |