| Analysis 1 (1:2) |  | Analysis 2 (1:2) |  | ||||||
---|---|---|---|---|---|---|---|---|---|---|
Group | S-1 | P-based | Â | S-1 | OBS | Â | ||||
 | S-1 (n = 59) | Platinum-based (n = 118) | p | S-1 (n = 56) | Surgery alone (n = 112) | p | ||||
Age, median (IQR) | 65.6 | (57.3–76.7) | 60.1 | (51.1–68.2) | 0.119 | 65.5 | (56.0–74.7) | 71.1 | (61.2–75.5) | 0.103 |
Male, n (%) | 30 | (50.8) | 65 | (55.1) | 0.709 | 32 | (57.1) | 62 | (55.3) | 0.956 |
Disease stage, n (%) | Â | 0.671 | Â | 0.252 | ||||||
 I-II | 17 | (28.8) | 29 | (24.6) |  | 24 | (42.9) | 60 | (53.5) |  |
 III | 42 |  | 89 |  |  | 32 |  | 52 |  |  |
pT stage, n (%) | Â | 0.442 | Â | Â | Â | Â | 0.397 | |||
 T1–2 | 8 | (13.6) | 23 | (19.5) |  | 10 | (17.9) | 28 | (25.0) |  |
 T3–4 | 51 |  | 95 |  |  | 46 |  | 84 |  |  |
pN stage, n (%) | Â | 0.288 | Â | 0.208 | ||||||
 N0–1 | 24 | (40.7) | 37 | (31.3) |  | 26 | (46.4) | 65 | (58.0) |  |
 N2–3 | 35 |  | 81 |  |  | 30 |  | 47 |  |  |
ECOG ≥ 2, n (%) | 4 | (6.8) | 9 | (7.6) | 0.919 | 4 | (7.1) | 12 | (10.7) | 0.642 |
HER2-positive, n (%) | 3 | (5.1) | 8 | (6.8) | 0.945 | 4 | (7.1) | 10 | (8.9) | 0.921 |
Tumor at GEJ, n (%) | 4 | (6.8) | 5 | (4.2) | 0.717 | 4 | (7.1) | 5 | (4.5) | 0.716 |
Lauren histology type, n (%) | Â | 0.232 | Â | 0.781 | ||||||
 Intestinal | 23 | (39.0) | 34 | (28.8) |  | 21 | (37.5) | 46 | (41.1) |  |
 Diffuse | 24 | (40.7) | 67 | (56.8) |  | 23 | (41.1) | 48 | (42.9) |  |
 Mixed | 11 |  | 17 |  |  | 11 |  | 15 |  |  |
 Othersa | 1 |  | 0 |  |  | 1 |  | 3 |  |  |
Borrmann classification, n (%) | Â | Â | Â | Â | 0.945 | Â | Â | Â | Â | 0.676 |
 Infiltrative | 47 | (60.7) | 95 | (70.5) |  | 41 | (73.2) | 77 | (68.8) |  |
 Non-infiltrative | 12 |  | 23 |  |  | 15 |  | 35 |  |  |
LVI (+), n (%) | 43 | (72.9) | 96 | (81.4) | 0.271 | 39 | (69.6) | 72 | (64.3) | 0.604 |
Median CEA ng/mL, (IQR) | 1.8 | (1.3–2.8) | 2.4 | (1.3–3.5) | 0.213 | 1.9 | (1.3–2.6) | 2.1 | (1.5–4.4) | 0.072 |
H. pylori infection, n (%) | 9 | (15.3) | 34 | (28.8) | 0.072 | 10 | (17.9) | 23 | (20.5) | 0.837 |
Adjuvant chemotherapy, n (%) | ||||||||||
 S-1 | 59 |  | – |  |  | 56 |  | – |  |  |
 PFL | – |  | 71 |  |  | – |  | – |  |  |
 XELOX/FOLFOX | – |  | 47 |  |  | – |  | – |  |  |