Fig. 5
From: CD36 promotes vasculogenic mimicry in melanoma by mediating adhesion to the extracellular matrix
CD36 facilitates the migration of melanoma cells. (A) Left panel, quantitated data of the distance travelled by C32 melanoma cells towards 10% FBS with siCD36 (siRNA A or C) or siRNA control (Scrambled). Right panel, quantitated data of total number of invading cells normalized to control (si-SCR). Data are mean ± SEM from n = 3 experiments. ****p < 0.0001 vs si-SCR, one-way ANOVA. (B) Left confocal images are representatives taken at a distance of 100 μm from the Transwell membrane start point for si-SCR control or siCD36 (A and C). Images were captured via a 20x objective on a Zeiss LSM 700 confocal microscope. Right panel, quantitated data of the number of cells at 100 μm from the Transwell membrane start point. Data are mean ± SEM from n = 3 experiments. ** p < 0.01 vs si-SCR, one-way ANOVA