Fig. 9

Pathway profiles and single-sample gene-set enrichment analysis (ssGSEA) between the low and high-risk groups across the entire TCGA cohort. (a) Enriched pathway profiles of the entire set show the DEGs between different risk scores enriched in different pathways. ssGSEA was performed to calculate the enrichment scores of pathway activity. Each score is displayed in a cell, with a colour change indicating a low (green) to high (red) score. (b) Pearson’s correlation analysis preliminarily demonstrates that high-risk score (marked with *) is negatively correlated with some immune-related pathways (marked with **). Red indicates a positive correlation coefficient while green indicates a negative correlation. (c-d) Boxplots showing the score of immune-related cells (c) and functions (d). Adjusted p-values are labelled as: ***, p < 0.001; **, p < 0.01; *, p < 0.05; ns, not significant