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Table 1 Target doses referred to 95% of the volume. For carbon ions, the biological dose is based on the LEM1 model using an alpha/beta of 2Gy. The biologically effective dose in 2 Gy fractions (BED2Gy) is calculated assuming an alpha/beta value of 3 Gy for ACC tissue

From: Adenoid cystic Carcinoma and Carbon ion Only irradiation (ACCO): Study protocol for a prospective, open, randomized, two-armed, phase II study

  Experimental arm
C12-only RT
Control arm
Bimodal RT
(photon IMRT & C12)
CTV_basic CTV_boost CTV_basic CTV_boost
Single dose 3Gy(RBE) 3Gy(RBE) 2Gy 3Gy(RBE)
Total dose 51Gy(RBE) 15Gy(RBE) 50Gy 24Gy(RBE)
BED2Gy 61Gy 18Gy 50Gy 29Gy