|  | Change in FACT-MM total scorea | Change in FACT-G scorea | Change in FACT-MM TOI total scoreb | Change in MM domain scorec | ||||
---|---|---|---|---|---|---|---|---|---|
Max N | Coefficient (95% CI) | p-value | Coefficient (95% CI) | p-value | Coefficient (95% CI) | p-value | Coefficient (95% CI) | p-value | |
Cycle 2 | 71d | −3.94 (−8.03 to 0.16) | 0.059 | −3.87 (−6.66 to −1.08) | 0.007 | −4.86 (−8.44 to −1.29) | 0.008 | −0.10 (−2.11 to 1.92) | 0.926 |
Cycle 3 | 42 | −5.17 (−10.10 to −0.25) | 0.040 | −5.69 (−9.05 to −2.33) | 0.001 | −4.92 (−9.21 to −0.64) | 0.024 | 0.61 (−1.81 to 3.03) | 0.619 |
Cycle 4 | 25 | −5.47 (−11.38 to 0.45) | 0.070 | −4.00 (−8.04 to 0.04) | 0.052 | −5.65 (−10.79 to −0.52) | 0.031 | −1.35 (−4.28 to 1.58) | 0.367 |
Cycle 5 | 13 | −3.97 (−11.58 to 3.65) | 0.307 | −3.62 (−8.82 to 1.59) | 0.173 | −4.60 (−11.22 to 2.03) | 0.174 | 0.21 (−3.43 to 3.85) | 0.911 |
Cycle 6 | 8e | −3.54 (−13.59 to 6.51) | 0.490 | −4.62 (−11.49 to 2.25) | 0.187 | −3.35 (−12.10 to 5.41) | 0.453 | 2.57 (−1.95 to 7.09) | 0.265 |
End of treatment | 39f | −10.45 (−16.19 to −4.70) | < 0.0001 | −8.14 (−11.68 to −4.60) | < 0.001 | −9.39 (−14.22 to −4.57) | < 0.001 | −1.80 (−4.93 to 1.34) | 0.261 |