Fig. 3
From: A positive-feedback loop between HBx and ALKBH5 promotes hepatocellular carcinogenesis
HBx up-regulates ALKBH5. A The protein level of ALKBH5 in the indicated cell lines. B ALKBH5 protein level in PHH cells with or without HBV WT or HBV MT virion infection. C ALKBH5 protein level in HepG2-NTCP cells with or without HBV WT or HBV MT virion infection. D Correlation analysis between HBx and ALKBH5 mRNA expression determined by RT-qPCR in tumors from 24 HBV-HCC patients. E, F ALKBH5 mRNA and protein levels in HepG2 cells with or without HBx transduction. WT, widetype; MT, mutant