Fig. 2

Distribution of simulated plasma concentrations (median with 95% CI) across body surface area (BSA) quartiles for BSA-based, flat and stratified dosing. Dashed horizontal lines represent the desired threshold plasma concentrations (< 1 μmol/L at 42 h post-dose and < 0.3 μmol/L at 48 h post-dose). Description of doses under each regimen is presented in Table 4