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Table 2 Pathology of NC cases and established cell lines

From: Incidence of NUT carcinoma in Western Australia from 1989 to 2014: a review of pediatric and adolescent cases from Perth Children’s Hospital

Patient

Tumor site

Histopathologya

Cytokeratin staininga

NUTM1 staininga

Cytogenetics of tumora

Cell line established

2

Lung

Poorly differentiated carcinoma focal squamous differentiation

YES (focal)

YES

t(15;19)(q14;p13.1)

PER-403

3

Sternal mass

Highly necrotic small cell, poorly differentiated carcinoma, with focal epithelial differentiation

YES (focal)

YES

46 XX (probably stromal cells growth rather than tumor)

 

4

Nasopharynx

Poorly differentiated carcinoma, focal abrupt squamous differentiation

YES (very focal)

NO (Technical problem)

46 XY, t(15;19) (?p11;?q12)

PER-704

6

Bronchus

Highly necrotic small cell, poorly differentiated carcinoma, with focal epithelial differentiation

YES (focal)

YES

46 XX, t(1;18;7)(q42;q11.2;q21), t(6;19)(q13;p13.1)

FISH: cryptic BRD4-NUT

PER-624

11

Paraspinal L4

Small round blue cell tumor, some neural features

YES (very focal)

YES

46, XX, t(15;19)(q13;q13.3)

 
  1. aTumor specimen from patient