Table 3 Univariate and multivariate analyses for progression-free survival (PFS)

Age, years

0.138

0.008

  ≤ 50

1.0

1.0

 >50

0.75 (0.51–1.10)

0.69 (0.52–0.91)

Gender

0.780

 Female

1.0

 Male

1.09 (0.59–2.04)

Vascular invasion

0.025

< 0.001

 No

1.0

1.0

 Yes

1.57 (1.06–2.33)

2.19 (1.42–3.36)

Extrahepatic metastasis

0.001

0.014

 No

1.0

1.0

 Yes

1.97 (1.34–2.91)

1.67 (1.11–2.49)

ALBI grade

< 0.001

<0.001

 I

1.0

1.0

 II

2.13 (1.45–3.13)

2.04 (1.39–3.00)

AFP reduction> 50%

<0.001

<0.001

 No

1.0

1.0

 Yes

0.37 (0.25–0.56)

0.38 (0.23–0.61)

PIVKA-II reduction> 50%

0.001

0.021

 No

1.0

1.0

 Yes

0.46 (0.31–0.68)

0.60 (0.39–0.93)

Baseline AFP level > 400 ng/ml

< 0.001

0.001

 No

1.0

1.0

 Yes

2.37 (1.49–3.77)

2.25 (1.41–3.59)

Baseline PIVKA-II level > 400 mAU/ml

0.164

 No

1.0

 Yes

1.47 (0.85–2.55)