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Table 4 Logistic regression analysis to examine risk factors for major postoperative complications

From: Preoperative prognostic nutritional index predicts postoperative infectious complications and oncological outcomes after hepatectomy in intrahepatic cholangiocarcinoma

Variables Univariate analysis Multivariate analysis
Odds ratio 95% C.I. P-value Odds ratio 95% C.I. P-value
Preoperative factors
 Age: ≥80 vs < 80 (years) 1.965 1.009 3.828 0.046 1.575 0.752 3.298 0.228
 BMI 0.959 0.886 1.037 0.291     
 Platelet count (104/uL) 1.016 0.981 1.051 0.370     
 Total Bilirubin (mg/dl) 1.062 0.863 1.309 0.566     
 PNI: <  50 vs ≥ 50 2.395 1.331 4.312 0.002 2.072 1.143 3.961 0.027
 AST (U/L) 1.001 0.998 1.005 0.308     
 ALT (U/L) 1.003 0.998 1.009 0.183     
 Prothrombin time (INR) 1.106 0.184 6.623 0.912     
 Total Cholesterol (mg/dL) 1.001 0.995 1.006 0.717     
 CRP (mg/dl) 1.082 0.970 1.207 0.162     
 Preoperative chemotherapy 2.928 0.639 13.42 0.167     
Tumor factor
 Morphology: Mass-forming vs the other type 0.806 0.440 1.479 0.487     
 Tumor size (cm) 1.049 0.957 1.151 0.298     
 Multi-nodular 1.382 0.724 2.637 0.326     
 Localization: Hilar vs Peripheral 2.523 1.151 5.530 0.020 2.548 1.143 5.683 0.022
 CEA (ng/ml) 1.003 0.992 1.013 0.608     
 CA19–9 (U/ml) 1.000 0.999 1.000 0.827     
 Vascular invasion* 1.172 0.680 2.020 0.566     
 Lymph node metastasis 1.122 0.579 2.171 0.732     
 Tumor differentiation: mod/por vs well 1.662 0.889 3.111 0.112     
Operative factors
 Major hepatectomy vs Minor hepatectomy 1.570 0.832 2.962 0.153     
 Lymph node dissection 1.254 0.686 2.294 0.460     
 Bile duct resection 3.456 1.948 6.129 0.001 1.135 0.491 2.625 0.767
 Vascular reconstruction** 2.473 1.030 5.937 0.042 1.061 0.393 2.870 0.906
 Blood loss (ml) 1.001 1.000 1.001 0.032 1.000 0.999 1.000 0.612
 Operation time (min) 1.004 1.002 1.006 0.001 1.003 1.000 1.006 0.026
  1. *vascular invasion: pathologically diagnosed as invasion to portal vein, hepatic artery, hepatic vein, and inferior vena cava
  2. **reconstruction including portal vein, hepatic artery, hepatic vein, and inferior vena cava