Table 3 Functional analysis of possible prognostic genes for the progression of cervical cancer
Gene | Function |
|---|---|
MCM2 | Minichromosome maintenance complex component 2. MCM2 is involved in the initiation of eukaryotic genome replication. It may be involved in the formation of replication forks and in the recruitment of other DNA replication-related proteins, and it regulates the helicase activity of the complex. |
TOP2A | DNA topoisomerase II a. These findings might provide target genes for the prognosis and treatment of cervical carcinoma. TOP2A controls and alters the topologic state of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. |
BLM | BLM RecQ-like helicase. This Bloom-associated helicase unwinds a variety of DNA substrates including Holliday junctions and is involved in several pathways contributing to the maintenance of genome stability. |
RMI2 | RecQ-mediated genome instability 2. RMI2 plays a role in homologous recombination-dependent DNA repair and is essential for genome stability. |
EXO1 | Exonuclease 1. EXO1, with 5′ to 3′ exonuclease activity as well as RNase H activity, interacts with Msh2, which is involved in mismatch repair and recombination. |
RFC4 | Replication factor C subunit 4. The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). |
PSCA | Prostate stem cell antigen. PSCA is highly expressed in the prostate and also expressed in the bladder, placenta, colon, kidney, and stomach. This gene is upregulated in a large proportion of prostate cancers and is also detected in cancers of the bladder and pancreas. |
KNTC1 | Kinetochore-associated 1. KNTC1 ensures proper chromosome segregation during cell division. |
CDC45 | Cell division cycle 45. CDC45, an essential protein required for the initiation of DNA replication, is important for the early steps of DNA replication in eukaryotes. |
GINS2 | GINS complex subunit 2. The GINS complex is essential for the initiation of DNA replication. |
CXCL8 | C-X-C motif chemokine ligand 8. CXC is a major mediator of the inflammatory response. This protein is also secreted by tumor cells and promotes tumor migration, invasion, angiogenesis and metastasis. This chemokine is also a potent angiogenic factor. |
TNFAIP6 | TNF alpha-induced protein 6. TNFAIP6 is a member of the hyaluronan-binding protein family. Its hyaluronan-binding domain is involved in extracellular matrix stability and cell migration. This protein is important in the protease network associated with inflammation. |
CXCL5 | C-X-C motif chemokine ligand 5. Chemokines, which recruit and activate leukocytes, promote angiogenesis and remodel connective tissues. It plays a role in cancer cell proliferation, migration, and invasion. |
CDA | Cytidine deaminase. CDA is one of several deaminases responsible for maintaining the cellular pyrimidine pool. |