Univariate (N = 18,264) | Multivariate (N = 18,264) | ||||||
---|---|---|---|---|---|---|---|
Variables | late or no access / early access | OR | IC 95% | p-value | OR | IC 95% | p-value |
Individual and clinical variables | |||||||
Sex | <.0001 | 0.0048 | |||||
Male | 3562/5656 | 1 | 1 | ||||
Female | 3918/5128 | 1.21 | [1.14;1.28] | 1.09 | [1.02;1.16] | ||
Age | <.0001 | 0.0249 | |||||
> =75 | 1622/2711 | 1 | 1 | ||||
[18–25[ | 261/373 | 1.17 | [0.98;1.38] | 0.98 | [0.82;1.18] | ||
[25–50[ | 1959/2536 | 1.29 | [1.18;1.40] | 1.12 | [1.03;1.23] | ||
[50–75[ | 3638/5164 | 1.17 | [1.09;1.26] | 1.10 | [1.02;1.19] | ||
Year of diagnosis | 0.0018 | 0.0061 | |||||
2011 | 1601/2315 | 1 | 1 | ||||
2012 | 1706/2501 | 0.98 | [0.90;1.07] | 0.95 | [0.87;1.04] | ||
2013 | 1949/3017 | 0.93 | [0.85;1.01] | 0.9 | [0.82;0.98] | ||
2014 | 2224/2951 | 1.09 | [1.00;1.18] | 1.03 | [0.95;1.13] | ||
Type of tumour | <.0001 | < 0.0001 | |||||
Soft tissue | 4666/7594 | 1 | 1 | ||||
Bone | 474/578 | 1.33 | [1.17;1.51] | 1.10 | [0.96;1.26] | ||
Viscera – GIST | 917/1520 | 0.98 | [0.89;1.07] | 1.11 | [0.99;1.26] | ||
Viscera - No GIST | 1423/1092 | 2.12 | [1.94;2.31] | 1.96 | [1.78;2.15] | ||
Depth of tumour | 0,0007 | ||||||
Superficial and deep | 394/650 | 1 | |||||
Superficial | 1526/2376 | 1.06 | [0.92;1.22] | ||||
Deep | 4865/6873 | 1.16 | [1.02;1.33] | ||||
Missing | 695/885 | 1.29 | [1.10;1.52] | ||||
Size of tumour | <.0001 | < 0.0001 | |||||
> =200 | 475/873 | 1 | 1 | ||||
[50–200[ | 3304/5008 | 1.21 | [1.07;1.36] | 1.15 | [1.02;1.31] | ||
[0–50[ | 2236/3294 | 1.24 | [1.10;1.41] | 1.30 | [1.14;1.48] | ||
Missing | 1465/1609 | 1.67 | [1.46;1.91] | 1.51 | [1.31;1.74] | ||
Histotype category | <.0001 | ||||||
GIST | 983/1621 | 1 | |||||
Sarcoma | 4657/6179 | 1.24 | [1.13;1.35] | ||||
Tumour of intermediate malignancy | 1840/2984 | 1.01 | [0.92;1.12] | ||||
Grade | <.0001 | < 0.0001 | |||||
1 | 749/1201 | 1 | 1 | ||||
2 | 2312/3784 | 0.98 | [0.88;1.08] | 0.89 | [0.80;0.99] | ||
3 | 1266/1887 | 1.07 | [0.95;1.20] | 1.02 | [0.91;1.15] | ||
Not applicable | 1236/876 | 2.26 | [1.99;2.56] | 1.83 | [1.61;2.10] | ||
Missing | 1917/3036 | 1.01 | [0.90;1.12] | 0.93 | [0.82;1.06] | ||
Geographical variables | |||||||
Region | <.0001 | < 0.0001 | |||||
Auvergne-Rhône-Alpes | 1013/1319 | 1 | 1 | ||||
Nouvelle-Aquitaine | 564/1527 | 0.48 | [0.42;0.54] | 0.46 | [0.40;0.52] | ||
Pays-de-la-Loire | 327/709 | 0.60 | [0.51;0.70] | 0.60 | [0.51;0.71] | ||
Centre-Val de Loire | 233/470 | 0.64 | [0.54;0.77] | 0.64 | [0.54;0.77] | ||
Provence-Alpes-Côte-d’Azur | 656/1241 | 0.68 | [0.60;0.78] | 0.69 | [0.61;0.79] | ||
Bretagne | 339/659 | 0.67 | [0.57;0.78] | 0.70 | [0.59;0.82] | ||
Corse | 46/76 | 0.78 | [0.54;1.14] | 0.72 | [0.49;1.07] | ||
Occitanie | 672/1131 | 0.77 | [0.68;0.87] | 0.78 | [0.69;0.89] | ||
Bourgogne-Franche-Comté | 333/538 | 0.80 | [0.68;0.94] | 0.83 | [0.70;0.97] | ||
Grand-Est | 732/838 | 1.13 | [1.00;1.29] | 1.18 | [1.04;1.35] | ||
Hauts-de-France | 737/744 | 1.29 | [1.13;1.47] | 1.31 | [1.14;1.50] | ||
Normandie | 301/287 | 1.36 | [1.13;1.63] | 1.43 | [1.18;1.72] | ||
Ile-de-France | 1527/1245 | 1.59 | [1.42;1.78] | 1.77 | [1.57;2.00] | ||
GeoClasH classification of municipalities | <.0001 | ||||||
Wealthy Metropolitan Areas | 1824/2071 | 1 | |||||
Precarious Population Districts | 3837/5748 | 0.75 | [0.70;0.81] | ||||
Residential Outskirts | 913/1394 | 0.74 | [0.67;0.82] | ||||
Agricultural and Industrial Plains | 582/968 | 0.68 | [0.60;0.77] | ||||
Rural Margins | 324/603 | 0.61 | [0.52;0.70] | ||||
Travel time to the closest reference centre for sarcoma diagnosis in minutes, quintiles) | <.0001 | 0.0073 | |||||
< = 21 | 1581/2119 | 1 | 1 | ||||
] 21; 47.5] | 1548/2082 | 0.99 | [0.90;1.09] | 1.05 | [0.95;1.16] | ||
] 47.5; 73.5] | 1484/2187 | 0.90 | [0.82;0.99] | 1.10 | [0.99;1.21] | ||
] 73.5; 97.5] | 1491/2125 | 0.94 | [0.85;1.03] | 1.18 | [1.06;1.31] | ||
> 97.5 | 1376/2271 | 0.81 | [0.74;0.89] | 1.18 | [1.06;1.31] | ||
European Deprivation Index (quintiles) | < 0.0001 | ||||||
< = − 1.3 (least deprived) | 1478/2188 | 1 | |||||
]-1.3; 1.8] | 1386/2227 | 0.92 | [0.83;1.01] | ||||
]1.8; 5.6] | 1438/2248 | 0.94 | [0.86;1.04] | ||||
]5.6; 9.2] | 1501/2218 | 1.00 | [0.91;1.09] | ||||
> 9.2 (most deprived) | 1677/1903 | 1.30 | [1.18;1.43] | ||||
Population density (number of inhabitants/km2, quintiles) | < 0.0001 | ||||||
< = 94.0926 | 1364/2304 | 1 | |||||
] 94.0926; 306.127] | 1399/2226 | 0.68 | [0.62;0.74] | ||||
] 306.127; 1034.61] | 1462/2184 | 0.72 | [0.65;0.79] | ||||
] 1034.61; 3693.94] | 1547/2104 | 0.77 | [0.70;0.84] | ||||
> 3693.94 | 1708/1966 | 0.84 | [0.77;0.92] | ||||
APL index (spatial accessibility to general practitioners, quintiles) | < 0.0001 | ||||||
< = 49.1 (lowest accessibility) | 1528/2094 | 1 | |||||
] 49.1; 64] | 1707/1973 | 1.18 | [1.08;1.30] | ||||
] 64; 78.4] | 1408/2142 | 0.90 | [0.82;0.99] | ||||
] 78.4; 90.7] | 1403/2345 | 0.82 | [0.74;0.90] | ||||
> 90.7 (highest accessibility) | 1434/2230 | 0.88 | [0.80;0.96] |