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Fig. 5 | BMC Cancer

Fig. 5

From: Pooled CRISPR screening in pancreatic cancer cells implicates co-repressor complexes as a cause of multiple drug resistance via regulation of epithelial-to-mesenchymal transition

Fig. 5

A ChIP-seq analysis reveals ChIP-seq peaks in the control (CTL) MiaPaCa-2 cells overlap significantly with MiaPaCa-2 cells over-expressing HDAC1 (red). An additional 17,501 peaks are identified with overexpression of HDAC1. B Cumulative distribution plot showing that HDAC1 binding sites identified upon overexpression of HDAC1 (blue) are nearby transcription start sites (TSS) of differentially expressed genes. C Scratch assay shows that overexpression of HDAC1 leads to increased migration compared to control cells. D Quantification of the scratch assays shows a significant difference with HDAC1 overexpression (Student’s T-test)

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BMC Cancer

ISSN: 1471-2407

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