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Fig. 4 | BMC Cancer

Fig. 4

From: Pooled CRISPR screening in pancreatic cancer cells implicates co-repressor complexes as a cause of multiple drug resistance via regulation of epithelial-to-mesenchymal transition

Fig. 4

A Scatter plot showing pathways enriched for multi-drug resistance in our CRISPRact and CRISPRko screens and their association with patient survival in the TCGA cohort. Patient survival is represented by the size and color of the circle. B A volcano plot shows that activation of HDAC1 expression using a dCas9-activation approach results in strong overexpression of HDAC1 based on RNA-sequencing. C Pathway enrichment analysis shows that HDAC1 overexpression especially affects epithelial-to-mesenchymal transition (EMT), cell efflux, apoptosis, autophagy, and DNA repair. P-values reported are derived from Fisher’s exact test comparing observed versus expected number of genes in each pathway. A full list is available in Supplemental Table S5. D Overexpression of each of the target genes listed on top right quadrant leads to a similar pattern of overexpression of genes shown on the lower right

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BMC Cancer

ISSN: 1471-2407

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