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Fig. 3 | BMC Cancer

Fig. 3

From: The role of FoxP3+ regulatory T cells and IDO+ immune and tumor cells in malignant melanoma – an immunohistochemical study

Fig. 3

Double immunofluorescence staining of CD68 + IDO, CD68 + CD11c and FoxP3 + IDO. Double stainings for CD68 + IDO (a) and CD68 + CD11c (b) from serial sections show that part of the CD68+ antigen presenting cells express IDO (a, colocalization, yellow, white arrows) and these same cells are also CD11c + (b, colocalization, yellow, white arrows). Most of the CD68+ cells do not express IDO (c), which suggest that the main IDO-expressing antigen presenting cells are CD11c + dendritic cells. Double stainings for FoxP3 + IDO (d) shows the colocalization of Tregs with IDO-expressing tumor cells (d, white arrows). a, b and d from lymph node metastases and c from superficial melanoma (pT1). Scale bar 50 μm (× 200 magnification)

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BMC Cancer

ISSN: 1471-2407

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