Table 2 Univariate analysis to identify OS-related genes
From: Genetic alteration of Chinese patients with rectal mucosal melanoma
Type | Genes | Occurrence (%) | HR(95%CI) | P-value |
|---|---|---|---|---|
Mutation | NF1 | 22.2% | 0.418 (0.141–1.238) | 0.115 |
Mutation | KIT | 16.7% | 1.387 (0.548–3.513) | 0.490 |
Mutation | BARD1 | 16.7% | 1.217 (0.415–3.570) | 0.721 |
Mutation | SPTA1 | 13.9% | 0.565 (0.166–1.918) | 0.360 |
Mutation | MGA | 13.9% | 1.619 (0.551–4.756) | 0.381 |
Mutation | SF3B1 | 13.9% | 1.510 (0.514–4.433) | 0.453 |
Mutation | BCR | 13.9% | 0.565 (0.166–1.918) | 0.360 |
Mutation | TP53 | 11.1% | 1.971 (0.653–5.952) | 0.229 |
Mutation | BRAF | 11.1% | 4.644 (1.495–14.425) | 0.008 |
Mutation | GNAS | 8.3% | 1.570 (0.461–5.349) | 0.471 |
Mutation | CTNNB1 | 8.3% | 1.057 (0.246–4.535) | 0.941 |
Mutation | SPEN | 8.3% | 0.518 (0.120–2.226) | 0.376 |
Mutation | CDH1 | 8.3% | 0.923 (0.271–3.138) | 0.898 |
Mutation | PTPRT | 8.3% | 2.108 (0.618–7.195) | 0.234 |
Mutation | NOTCH3 | 8.3% | 0.266 (0.036–1.983) | 0.196 |
Mutation | ERBB4 | 8.3% | 0.604 (0.141–2.585) | 0.496 |
Amplification | MYC | 25.0% | 1.168 (0.432–3.227) | 0.764 |
Amplification | PDGFRA | 22.2% | 0.490 (0.146–1.648) | 0.249 |
Amplification | CCND3 | 19.4% | 0.693 (0.236–2.036) | 0.505 |
Amplification | KIT | 19.4% | 0.688 (0.199–2.248) | 0.515 |
Amplification | FGF6 | 16.7% | 0.856 (0.290–2.523) | 0.778 |
Amplification | FGF23 | 11.1% | 1.005 (0.296–3.413) | 0.994 |
Amplification | CCNE1 | 11.1% | 1.046 (0.310–3.526) | 0.942 |
Deletion | PTEN | 16.7% | 1.655 (0.655–4.183) | 0.287 |
Deletion | NRG1 | 8.3% | 16.478 (3.269–83.066) | 0.001 |