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Table 3 Cox regression analysis of cancer-specific survival

From: 53 years old is a reasonable cut-off value to define young and old patients in clear cell renal cell carcinoma: a study based on TCGA and SEER database

Characteristic

Univariate cox regression before PSM

Multivariate cox regression before PSM

Multivariate cox regression after PSM

95%CL

P

95%CL

P

95%CL

P

Age

 Young(≤53 y)

Reference

 

Reference

 

Reference

 

 Old(> 53 y)

1.834 (1.731–1.942)

< 0.001

1.549 (1.462–1.642)

< 0.001

1.573 (1.470–1.682)

< 0.001

Sex

 Male

Reference

 

Reference

 

Reference

 

 Female

0.781 (0.743–0.821)

< 0.001

1.008 (0.957–1.061)

0.769

1.023 (0.950–1.102)

0.549

Race

 Black

Reference

 

Reference

 

Reference

 

 White

0.969 (0.879–1.068)

0.525

    

 Other

0.924 (0.811–1.052)

0.233

    

Marital

 Single/Other

Reference

 

Reference

 

Reference

 

 Married

0.911 (0.866–0.957)

< 0.001

0.843 (0.801–.887)

< 0.001

0.824 (0.769–0.884)

< 0.001

Size

 Dmax<=4 cm

Reference

 

Reference

 

Reference

 

 4 cm < Dmax<=7 cm

3.886 (3.566–4.233)

< 0.001

2.324 (2.127–2.540)

< 0.001

2.433 (2.153–2.750)

< 0.001

 Dmax> 7 cm

11.792 (10.896–12.762)

< 0.001

3.710 (3.393–4.055)

< 0.001

4.299 (3.814–4.845)

< 0.001

Grade

 I

Reference

 

Reference

 

Reference

 

 II

1.420 (1.287–1.567)

< 0.001

1.028 (0.931–1.135)

0.583

1.051 (0.918–1.203)

0.472

 III

4.020 (3.649–4.428)

< 0.001

1.514 (1.369–1.675)

< 0.001

1.615 (1.405–1.855)

< 0.001

 IV

10.814 (9.738–12.009)

< 0.001

2.229 (1.995–2.490)

< 0.001

2.264 (1.944–2.636)

< 0.001

Laterality

 Left

Reference

 

Reference

 

Reference

 

 Right

0.931 (0.887–0.976)

0.003

0.954 (0.910–1.001)

0.054

0.940 (0.880–1.005)

0.07

SEER historic stage A

 Localized

Reference

 

Reference

 

Reference

 

 Regional

4.934 (4.637–5.249)

< 0.001

2.615 (2.443–2.798)

< 0.001

2.641 (2.402–2.903)

< 0.001

 Distant

25.576 (24.104–27.

138)

< 0.001

9.900 (9.172–10.685)

< 0.001

10.134 (9.108–11.276)

< 0.001

Radiation

 NO

Reference

 

Reference

 

Reference

 

 YES

9.242 (8.574–9.962)

< 0.001

1.446 (1.334–1.568)

< 0.001

1.458 (1.309–1.625)

< 0.001

chemotherapy

 NO

Reference

 

Reference

 

Reference

 

 YES

8.887 (8.369–9.438)

< 0.001

1.179 (1.100–1.263)

< 0.001

1.268 (1.152–1.396)

< 0.001

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