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Table 3 Cox regression analysis of cancer-specific survival

From: 53 years old is a reasonable cut-off value to define young and old patients in clear cell renal cell carcinoma: a study based on TCGA and SEER database

Characteristic Univariate cox regression before PSM Multivariate cox regression before PSM Multivariate cox regression after PSM
95%CL P 95%CL P 95%CL P
Age
 Young(≤53 y) Reference   Reference   Reference  
 Old(> 53 y) 1.834 (1.731–1.942) < 0.001 1.549 (1.462–1.642) < 0.001 1.573 (1.470–1.682) < 0.001
Sex
 Male Reference   Reference   Reference  
 Female 0.781 (0.743–0.821) < 0.001 1.008 (0.957–1.061) 0.769 1.023 (0.950–1.102) 0.549
Race
 Black Reference   Reference   Reference  
 White 0.969 (0.879–1.068) 0.525     
 Other 0.924 (0.811–1.052) 0.233     
Marital
 Single/Other Reference   Reference   Reference  
 Married 0.911 (0.866–0.957) < 0.001 0.843 (0.801–.887) < 0.001 0.824 (0.769–0.884) < 0.001
Size
 Dmax<=4 cm Reference   Reference   Reference  
 4 cm < Dmax<=7 cm 3.886 (3.566–4.233) < 0.001 2.324 (2.127–2.540) < 0.001 2.433 (2.153–2.750) < 0.001
 Dmax> 7 cm 11.792 (10.896–12.762) < 0.001 3.710 (3.393–4.055) < 0.001 4.299 (3.814–4.845) < 0.001
Grade
 I Reference   Reference   Reference  
 II 1.420 (1.287–1.567) < 0.001 1.028 (0.931–1.135) 0.583 1.051 (0.918–1.203) 0.472
 III 4.020 (3.649–4.428) < 0.001 1.514 (1.369–1.675) < 0.001 1.615 (1.405–1.855) < 0.001
 IV 10.814 (9.738–12.009) < 0.001 2.229 (1.995–2.490) < 0.001 2.264 (1.944–2.636) < 0.001
Laterality
 Left Reference   Reference   Reference  
 Right 0.931 (0.887–0.976) 0.003 0.954 (0.910–1.001) 0.054 0.940 (0.880–1.005) 0.07
SEER historic stage A
 Localized Reference   Reference   Reference  
 Regional 4.934 (4.637–5.249) < 0.001 2.615 (2.443–2.798) < 0.001 2.641 (2.402–2.903) < 0.001
 Distant 25.576 (24.104–27.
138)
< 0.001 9.900 (9.172–10.685) < 0.001 10.134 (9.108–11.276) < 0.001
Radiation
 NO Reference   Reference   Reference  
 YES 9.242 (8.574–9.962) < 0.001 1.446 (1.334–1.568) < 0.001 1.458 (1.309–1.625) < 0.001
chemotherapy
 NO Reference   Reference   Reference  
 YES 8.887 (8.369–9.438) < 0.001 1.179 (1.100–1.263) < 0.001 1.268 (1.152–1.396) < 0.001