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Table 2 Cox regression analysis of overall survival

From: 53 years old is a reasonable cut-off value to define young and old patients in clear cell renal cell carcinoma: a study based on TCGA and SEER database

Characteristic Univariate cox regression before PSM Multivariate cox regression before PSM Multivariate cox regression after PSM
95%CI P 95%CI P 95%CI P
Age
 Young(≤53 y) Reference   Reference   Reference  
 Old(> 53 y) 2.338 (2.228–2.453) < 0.001 2.132 (2.031–2.238) < 0.001 2.128 (2.015–2.247) < 0.001
Sex
 Male Reference   Reference   Reference  
 Female 0.829 (0.789–0.862) < 0.001 0.909 (0.873–0.947) < 0.001 0.910 (0.859–0.964) 0.001
Race
 Black Reference   Reference   Reference  
 White 0.895 (0.831–0.964) 0.003 0.836 (0.776–0.901) < 0.001 0.795 (0.722–0.876) < 0.001
 Other 0.798 (0.721–0.884) 0 < 0.001 0.716 (0.647–0.794) < 0.001 0.682 (0.593–0.783) < 0.001
Marital
 Single/Other Reference   Reference   Reference  
 Married 0.780 (0.751–0.811) < 0.001 0.729 (0.701–0.758) < 0.001 0.711 (0.674–0.750) < 0.001
Size
 Dmax<=4 cm Reference   Reference   Reference  
 4 cm < Dmax<=7 cm 1.967 (1.868–2.070) < 0.001 1.403 (1.330–1.480) < 0.001 1.382 (1.284–1.488) < 0.001
 Dmax> 7 cm 4.084 (3.895–4.283) < 0.001 1.849 (1.748–1.956) < 0.001 1.965 (1.823–2.118) < 0.001
Grade
 I Reference   Reference   Reference  
 II 1.151 (1.081–1.225) < 0.001 0.966 (0.907–1.029) 0.283 0.988 (0.907–1.075) 0.773
 III 2.225 (2.086–2.373) < 0.001 1.213 (1.133–1.298) < 0.001 1.287 (1.172–1.412) < 0.001
 IV 5.296 (4.911–5.712) < 0.001 1.823 (1.681–1.978) < 0.001 1.856 (1.661–2.075) < 0.001
Laterality   < 0.001     
 Left Reference   Reference   Reference  
 Right 0.936 (0.902–0.971) < 0.001 0.953 (0.918–0.989) 0.012 0.947 (0.899–0.997) 0.038
SEER historic stage A
Localized Reference   Reference   Reference  
 Regional 2.705 (2.585–2.831) < 0.001 1.830 (1.740–1.925) < 0.001 1.860 (1.727–2.003) < 0.001
 Distant 11.243 (10.734–11.776) < 0.001 5.996 (5.631–6.383) < 0.001 6.694 (6.115–7.329) < 0.001
Radiation
 NO Reference   Reference   Reference  
 YES 6.150 (5.725–6.607) < 0.001 1.340 (1.239–1.450) < 0.001 1.319 (1.187–1.465) < 0.001
Chemotherapy
 NO Reference   Reference   Reference  
 YES 5.959 (5.637–6.299) < 0.001 1.196 (1.120–1.278) < 0.001 1.254 (1.144–1.375) < 0.001