Table 2 Cox regression analysis of overall survival

 Young(≤53 y)

Reference

Reference

Reference

 Old(> 53 y)

2.338 (2.228–2.453)

< 0.001

2.132 (2.031–2.238)

< 0.001

2.128 (2.015–2.247)

< 0.001

 Male

Reference

Reference

Reference

 Female

0.829 (0.789–0.862)

< 0.001

0.909 (0.873–0.947)

< 0.001

0.910 (0.859–0.964)

0.001

 Black

Reference

Reference

Reference

 White

0.895 (0.831–0.964)

0.003

0.836 (0.776–0.901)

< 0.001

0.795 (0.722–0.876)

< 0.001

 Other

0.798 (0.721–0.884)

0 < 0.001

0.716 (0.647–0.794)

< 0.001

0.682 (0.593–0.783)

< 0.001

 Single/Other

Reference

Reference

Reference

 Married

0.780 (0.751–0.811)

< 0.001

0.729 (0.701–0.758)

< 0.001

0.711 (0.674–0.750)

< 0.001

 Dmax<=4 cm

Reference

Reference

Reference

 4 cm < Dmax<=7 cm

1.967 (1.868–2.070)

< 0.001

1.403 (1.330–1.480)

< 0.001

1.382 (1.284–1.488)

< 0.001

 Dmax> 7 cm

4.084 (3.895–4.283)

< 0.001

1.849 (1.748–1.956)

< 0.001

1.965 (1.823–2.118)

< 0.001

 I

Reference

Reference

Reference

 II

1.151 (1.081–1.225)

< 0.001

0.966 (0.907–1.029)

0.283

0.988 (0.907–1.075)

0.773

 III

2.225 (2.086–2.373)

< 0.001

1.213 (1.133–1.298)

< 0.001

1.287 (1.172–1.412)

< 0.001

 IV

5.296 (4.911–5.712)

< 0.001

1.823 (1.681–1.978)

< 0.001

1.856 (1.661–2.075)

< 0.001

Laterality

< 0.001

 Left

Reference

Reference

Reference

 Right

0.936 (0.902–0.971)

< 0.001

0.953 (0.918–0.989)

0.012

0.947 (0.899–0.997)

0.038

Localized

Reference

Reference

Reference

 Regional

2.705 (2.585–2.831)

< 0.001

1.830 (1.740–1.925)

< 0.001

1.860 (1.727–2.003)

< 0.001

 Distant

11.243 (10.734–11.776)

< 0.001

5.996 (5.631–6.383)

< 0.001

6.694 (6.115–7.329)

< 0.001

 NO

Reference

Reference

Reference

 YES

6.150 (5.725–6.607)

< 0.001

1.340 (1.239–1.450)

< 0.001

1.319 (1.187–1.465)

< 0.001

 NO

Reference

Reference

Reference

 YES

5.959 (5.637–6.299)

< 0.001

1.196 (1.120–1.278)

< 0.001

1.254 (1.144–1.375)

< 0.001