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Table 2 Radiographic patterns of 14 early-onset CIPs and 18 late-onset CIPs

From: Radiographic features and prognosis of early- and late-onset non-small cell lung cancer immune checkpoint inhibitor-related pneumonitis

 

Overall

N = 32

Early-onset CIP

N = 14

Late-onset CIP

N = 18

P

CIP location, n (%)

 Bilateral

25 (78.1)

10 (71.4)

15 (83.3)

0.459*

 Left

4 (12.5)

3 (21.4)

1 (5.6)

 

 Right

3 (9.4)

1 (7.2)

2 (11.1)

 

Number of lobes involved, n (%)

 1–3

10 (31.3)

5 (35.7)

7 (38.9)

0.712*

 4–5

22 (68.7)

9 (64.3)

11 (61.1)

 

Involves area of lung parenchyma

 ≤ 50%

14 (43.8)

4 (28.6)

11 (61.1)

0.087*

 > 50%

18 (56.2)

10 (71.4)

7 (38.9)

 

CT findings at onset of CIP, n (%)

 Ground glass opacity

29 (90.6)

13 (92.9)

16 (88.9)

0.598*

 Consolidation

12 (37.5)

7 (50.0)

5 (27.8)

 

 Reticulation

14 (43.8)

5 (35.7)

9 (50.0)

 

 Bronchitis/Nodularity

15 (46.9)

8 (57.1)

7 (38.9)

 

 Pleural effusion

2 (6.3)

0 (0)

2 (11.1)

 

Overall pattern of ILD, n (%)

 OP-like pattern

11 (34.4)

7 (50.0)

4 (22.2)

0.096*

 NSIP-like pattern

11 (34.4)

2 (14.3)

9 (50.0)

 

 AIP/HP/Others-like pattern

10 (31.3)

5 (35.7)

5 (27.8)

 

Grades of CIP, n (%)

 1–2

10 (31.3)

1 (7.1)

9 (50.0)

0.019*

 3–5

22 (68.7)

13 (92.9)

9 (50.0)

 

Prognosis, n (%)

 Survival

23 (71.9)

7 (50.0)

16 (88.9)

0.022*

 Dead

9 (28.1)

7 (50.0)

2 (11.1)

 
  1. * Fisher exact test