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Table 2 Radiographic patterns of 14 early-onset CIPs and 18 late-onset CIPs

From: Radiographic features and prognosis of early- and late-onset non-small cell lung cancer immune checkpoint inhibitor-related pneumonitis

  Overall
N = 32
Early-onset CIP
N = 14
Late-onset CIP
N = 18
P
CIP location, n (%)
 Bilateral 25 (78.1) 10 (71.4) 15 (83.3) 0.459*
 Left 4 (12.5) 3 (21.4) 1 (5.6)  
 Right 3 (9.4) 1 (7.2) 2 (11.1)  
Number of lobes involved, n (%)
 1–3 10 (31.3) 5 (35.7) 7 (38.9) 0.712*
 4–5 22 (68.7) 9 (64.3) 11 (61.1)  
Involves area of lung parenchyma
 ≤ 50% 14 (43.8) 4 (28.6) 11 (61.1) 0.087*
 > 50% 18 (56.2) 10 (71.4) 7 (38.9)  
CT findings at onset of CIP, n (%)
 Ground glass opacity 29 (90.6) 13 (92.9) 16 (88.9) 0.598*
 Consolidation 12 (37.5) 7 (50.0) 5 (27.8)  
 Reticulation 14 (43.8) 5 (35.7) 9 (50.0)  
 Bronchitis/Nodularity 15 (46.9) 8 (57.1) 7 (38.9)  
 Pleural effusion 2 (6.3) 0 (0) 2 (11.1)  
Overall pattern of ILD, n (%)
 OP-like pattern 11 (34.4) 7 (50.0) 4 (22.2) 0.096*
 NSIP-like pattern 11 (34.4) 2 (14.3) 9 (50.0)  
 AIP/HP/Others-like pattern 10 (31.3) 5 (35.7) 5 (27.8)  
Grades of CIP, n (%)
 1–2 10 (31.3) 1 (7.1) 9 (50.0) 0.019*
 3–5 22 (68.7) 13 (92.9) 9 (50.0)  
Prognosis, n (%)
 Survival 23 (71.9) 7 (50.0) 16 (88.9) 0.022*
 Dead 9 (28.1) 7 (50.0) 2 (11.1)  
  1. * Fisher exact test