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Table 2 Univariate and multivariate analysis of predictors of overall survival in the entire patient cohort

From: Socio-economic factors do not affect overall survival in soft tissue sarcoma when patients treated at a single high-volume center

 

Univariate Analysis

Multivariate Analysis

HR

95% CI

p-value*

HR

95% CI

p-value*

Variable

 Female Sex

0.71

(0.49–1.02)

0.066

0.74

(0.51–1.08)

0.12

 Age at diagnosis, per 10-year increase

1.09

(0.97–1.23)

0.15

1.06

(0.94–1.21)

0.33

 Marital Status

  

0.96

  

0.76

  Married/significant other

{ref.}

  

{ref.}

  

  Single/separated/divorced

1.01

(0.69–1.48)

 

0.94

(0.63–1.40)

 

 Employment status

  

0.32

  

0.72

  Full time/part time/student

{ref.}

  

{ref.}

  

  Unemployed/retired

1.36

(0.91–2.01)

 

1.18

(0.77–1.80)

 

  Unknown

1.21

(0.69–2.13)

 

1.19

(0.66–2.16)

 

 Location

  

0.073

   

  Urban (Metropolitan)

{ref.}

     

  Rural (Non-metropolitan)

0.55

(0.29–1.06)

    

 Average income per 50% increase

1.12

(0.88–1.43)

0.36

   

 Education quartile per 1-quartile increase

1.03

(0.86–1.24)

0.73

   

 Mean distance per 50% increase

0.94

(0.88–1.00)

0.057

   

 ADI WA decile per 1-decile increase

0.97

(0.90–1.04)

0.39

0.95

(0.88–1.02)

0.16

Tumor Characteristics

 Grade

  

< 0.001

  

< 0.001

  1

{ref.}

  

{ref.}

  

  2

1.39

(0.65–2.97)

 

1.43

(0.66–3.10)

 

  3

3.34

(1.66–6.73)

 

3.18

(1.54–6.54)

 

  Unknown

1.68

(0.77–3.65)

 

1.57

(0.72–3.45)

 

 Maximum extent on imaging

  

0.49

  

0.74

  ≤ 5 cm

{ref.}

  

{ref.}

  

  > 5 cm

1.46

(0.76–2.81)

 

1.29

(0.66–2.50)

 

  Unknown

1.46

(0.76–2.80)

 

1.29

(.066–2.53)

 

 Clinical N stage

  

0.019

  

0.017

  N0

{ref.}

  

{ref.}

  

  N1

2.94

(1.19–7.24)

 

3.07

(1.22–7.71)

 

  Unknown

   

1.94

(0.89–4.24)

 

Treatment

 

 Time from diagnosis to treatment,

per 50% increase

0.93

(0.84, 1.04)

0.20

0.96

(0.86–1.09)

0.55

  1. *Wald test of HR = 1, without adjustment for multiple comparisons