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Fig. 6 | BMC Cancer

Fig. 6

From: MCM6 indicates adverse tumor features and poor outcomes and promotes G1/S cell cycle progression in neuroblastoma

Fig. 6

MCM6 can regulate the cell cycle of neuroblastoma at both the cell and protein level. (A-D) Cell cycle analysis was performed on neuroblastoma cell lines using flow cytometry. After MCM6 silenced, SK-N-BE [2] and SK-N-SH cells both showed an increase in G1 phase components and a decrease in S phase components. (E) The expression of cell cycle regulated genes in different cell cycle phases of SK-N-BE [2] cells. (F) Verify the expression of cell cycle regulation related proteins by WB. The expression of CDK4 and CyclinD1 was down-regulated after MCM6 silence. (G-H) According to the cell cycle regulation pathway enriched by RNA-seq, the relevant genes on the pathway were verified by qPCR. The value is displayed as the mean ± SEM and statistical significance is expressed as **** p < 0.0001

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BMC Cancer

ISSN: 1471-2407

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