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Table 3 Associations of SNPs with second primary cancer risk in five case-control studies included in systematic review

From: Single nucleotide polymorphisms and the risk of developing a second primary cancer among head and neck cancer patients: a systematic literature review and meta-analysis

SNP Genes investigated Chromosome Author, year [Ref] Genotype SPC/recurrence Yes, n (%) No, n (%) HR LCI UCI OR LCI UCI
rs1042891 C > T CASP6 4 Guan X, 2013 [26] CC 480 (44.8) 462 (43.5) N/A N/A N/A 1   
CT 453 (42.5) 473 (43.7) N/A N/A N/A 0.92 0.77 1.12
TT 132 (12.4) 137 (12.8) N/A N/A N/A 0.91 0.69 1.21
CT/TT 592 (54.9) 610 (56.5) N/A N/A N/A 0.93 0.77 1.11
rs1049216 A > G CASP3 4 Guan X, 2013 [26] AA 581 (54.5) 542 (50.5) N/A N/A N/A 1   
AG 401 (37.6) 441 (41.0) N/A N/A N/A 0.83 0.68 1.00
GG 84 (7.9) 91 (8.5) N/A N/A N/A 0.86 0.62 1.20
AG/GG 485 (45.5) 532 (49.5) N/A N/A N/A 0.83 0.70 0.99
rs1049253 T > C CASP3 4 Guan X, 2013 [26] TT 669 (62.8) 734 (68.3) N/A N/A N/A 1   
TC 346 (32.4) 306 (28.5) N/A N/A N/A 1.24 1.02 1.15
CC 51 (4.8) 34 (3.2) N/A N/A N/A 1.80 1.13 2.87
TC/CC 397 (37.2) 340 (31.7) N/A N/A N/A 1.29 1.07 1.56
rs10787498 T > G CASP7 10 Guan X, 2013 [26] TT 466 (43.9) 470 (43.9) N/A N/A N/A 1   
GT 482 (45.4) 486 (45.4) N/A N/A N/A 1.03 0.85 1.24
GG 114 (10.7) 115(10.7) N/A N/A N/A 0.93 0.69 1.26
GT/GG 596 (56.1) 601 (56.1) N/A N/A N/A 1.01 0.84 1.20
rs11047917 KRAS 12 Wu X, 2009 [36] C > T 123/24/0 271/22/0 2.12 1.36 3.31 N/A N/A N/A
rs11061209 RAN 12 Zhang X, 2010 [38] AA+AG 123 (32.2) 259 (67.8) 1    N/A N/A N/A
GG 24 (41.4) 34 (58.6) 1.6 1.02 2.49 N/A N/A N/A
rs1127687 G > A CASP7 10 Guan X, 2013 [26] GG 613 (57.5) 635 (59.1) N/A N/A N/A 1   
AG 407 (38.2) 381 (35.5) N/A N/A N/A 1.09 0.9 1.31
AA 46 (4.3) 58 (5.4) N/A N/A N/A 0.8 0.52 1.21
AG/AA 453 (42.5) 439 (40.9) N/A N/A N/A 1.05 0.88 1.26
rs11586945 RGS5 1 Wang J, 2010 [24] GG 96 (65.3) 206 (70.3) 1    N/A N/A N/A
GC 41 (27.9) 76 (25.9) 1.11 0.77 1.62 N/A N/A N/A
CC 10 (6.8) 11 (3.7) 2.06 1.06 3.99 N/A N/A N/A
rs11594179 SUFU 10 Zhang X, 2010 [38] GG 103 (37.4) 172 (62.5) 1    N/A N/A N/A
AG + AA 44 (26.7) 121 (73.3) 0.67 0.47 0.96 N/A N/A N/A
AA 838 (78.1) 827 (77.1) N/A N/A N/A 1   
rs12247479 A > G CASP7 10 Guan X, 2013 [26] AG 219 (20.6) 228 (21.2) N/A N/A N/A 0.95 0.76 1.18
GG 14 (1.3) 18 (1.7) N/A N/A N/A 0.68 0.32 1.41
AG/GG 233 (21.9) 246 (22.9) N/A N/A N/A 0.93 0.75 1.15
rs12359892 MKI67 10 Wu X, 2009 [36] T > C 101/14/27 221/38/18 2.65 4.11 1.72 N/A N/A N/A
rs12888332 MNAT1 14 Wu X, 2009 [36] T > G 125/19/3 280/10/3 2.57 1.62 4.09 N/A N/A N/A
rs15864 GSTM3 1 Zhang X, 2010 [38] GG + GC 127 (35.2) 234 (64.8) 1    N/A N/A N/A
CC 8 (20.0) 32 (80.0) 0.49 0.24 1.00 N/A N/A N/A
rs17387169 PROM1 4 Wu X, 2009 [36] G > A 129/19/2 202/85/6 0.42 0.26 0.67 N/A N/A N/A
rs17410035 RNASEN 5 Zhang X, 2010 [38] CC + AC 141 (35.7) 254 (64.3) 1    N/A N/A N/A
AA 6 (13.6) 38 (86.4) 0.36 0.16 0.83 N/A N/A N/A
rs1884056 BCL2L2 14 Zhang X, 2010 [38] GG 59 (28.1) 151 (71.9) 1    N/A N/A N/A
AG 63 (36.2) 111 (63.8) 1.41 0.98 2.03 N/A N/A N/A
AA 25 (44.6) 31 (55.4) 1.85 1.14 3.01 N/A N/A N/A
rs2179653 RGS2 1 Wang J, 2010 [24] GG 103 (70.1) 208 (70.9) 1    N/A N/A N/A
GA 34 (23.1) 81 (27.6) 0.97 0.65 1.44 N/A N/A N/A
AA 10 (6.8) 4 (1.4) 2.93 1.50 5.73 N/A N/A N/A
rs2227301 XPO5 6 Zhang X, 2010 [38] GG+ AG 136 (32.6) 281 (67.4) 1    N/A N/A N/A
AA 11 (47.8) 12 (52.2) 1.91 1.02 3.58 N/A N/A N/A
rs2237724 CFTR 7 Wu X, 2009 [36] G > A 92/45/10* 198/89/6* 3.12 1.62 5.98 N/A N/A N/A
rs2300181 CAT 11 Wu X, 2009 [36] G > A 76/58/13* 163/124/6* 2.67 1.49 4.78 N/A N/A N/A
rs2306536 CHFR 12 Wu X, 2009 [36] G > A 87/49/11* 88/97/8* 3.14 1.65 5.99 N/A N/A N/A
rs359974 NHEJ1 2 Wu X, 2009 [36] T > C 93/44/10* 213/76/4* 4.26 2.18 8.32 N/A N/A N/A
rs3732360 NR1I2 3 Zhang X, 2010 [38] AA 63 (28.8) 156 (71.2) 1    N/A N/A N/A
AG 67 (36.6) 116 (63.4) 1.29 0.91 1.83 N/A N/A N/A
GG 17 (44.7) 21 (55.3) 1.96 1.12 3.44 N/A N/A N/A
rs3747238 SMC1B 22 Zhang X, 2010 [38] AA+AG 108 (31.1) 239 (68.8) 1    N/A N/A N/A
GG 39 (41.9) 54 (58.1) 1.74 1.19 2.54 N/A N/A N/A
rs3747813 RGS3 9 Wang J, 2010 [24] GG 136 (92.5) 258 (88.1) 1    N/A N/A N/A
GA 11 (7.4) 34 (11.6) 0.54 0.29 1.02 N/A N/A N/A
AA 0 1 (0.3) _    N/A N/A N/A
rs3792830 RNASEN 5 Zhang X, 2010 [38] TT 126 (31.9) 269 (68.1) 1    N/A N/A N/A
TC + CC 21 (46.7) 24 (53.3) 1.75 1.08 2.82 N/A N/A N/A
rs3795617 RGS13 1 Wang J, 2010 [24] GG 42 (28.6) 87 (29.7) 1    N/A N/A N/A
GA 80 (54.4) 119 (40.6) 1.18 0.81 1.72 N/A N/A N/A
AA 25 (17.0) 87 (29.7) 0.58 0.35 0.96 N/A N/A N/A
rs3805500 RNASEN 5 Zhang X, 2010 [38] CC 49 (25.8) 141 (74.2) 1    N/A N/A N/A
CT 69 (37.7) 114 (62.3) 1.52 1.05 2.20 N/A N/A N/A
TT 22 (44.0) 28 (56.0) 1.91 1.13 3.23 N/A N/A N/A
rs3826537 MRC2 17 Wu X, 2009 [36] A > G 67/63/17* 88/150/55* 0.57 0.41 0.79 N/A N/A N/A
rs3917328 IL1R1 2 Zhang X, 2010 [38] GG 131 (32.6) 271 (67.4) 1    N/A N/A N/A
AG + AA 16 (42.1) 22 (57.9) 1.8 1.05 3.07 N/A N/A N/A
rs4353229 T > C CASP7 10 Guan X, 2013 [26] TT 611 (57.4) 614 (57.2) N/A N/A N/A 1   
CT 387 (36.4) 403 (37.5) N/A N/A N/A 1.03 0.86 1.25
CC 66 (6.2) 57 (5.3) N/A N/A N/A 1.22 0.82 1.78
CT/CC 453 (42.6) 460 (42.8) N/A N/A N/A 1.06 0.88 1.26
rs506008 GSTM4 1 Wu X, 2009 [36] G > A 94/46/3* 232/54/1* 2.09 1.46 3.00 N/A N/A N/A
rs604337 GSTM4 1 Wu X, 2009 [36] C > T 94/50/3* 223/64/6* 1.84 1.29 2.61 N/A N/A N/A
rs639174 RNASEN 5 Zhang X, 2010 [38] CC + CT 132 (32.4) 276 (67.6) 1    N/A N/A N/A
TT 15 (48.4) 16 (51.6) 1.88 1.09 3.25 N/A N/A N/A
rs6670735 RGS8 1 Wang J, 2010 [24] AA 68 (46.3) 111 (38.0) 1    N/A N/A N/A
AG 58 (39.5) 147 (50.3) 0.64 0.45 0.92 N/A N/A N/A
GG 21 (14.3) 34 (11.6) 0.86 0.52 1.42 N/A N/A N/A
rs6684195 RNF2 1 Wu X, 2009 [36] A > G 50/64/33* 111/150/32* 2.12 1.43 3.14 N/A N/A N/A
rs6689169 RGS7 1 Wang J, 2010 [24] AA 120 (81.6) 211 (72.0) 1    N/A N/A N/A
AG 24 (16.3) 79 (26.9) 0.6 0.38 0.94 N/A N/A N/A
GG 3 (2.0) 3 (1.0) 1.65 0.52 5.24 N/A N/A N/A
rs669702 RNASEN 5 Zhang X, 2010 [38] GG 112 (31.5) 243 (68.4) 1    N/A N/A N/A
GA + AA 35 (41.2) 50 (58.8) 1.53 1.04 2.26 N/A N/A N/A
rs6884823 RNASEN 5 Zhang X, 2010 [38] GG 120 (31.5) 261 (68.5) 1    N/A N/A N/A
GA + AA 27 (45.7) 32 (54.3) 1.71 1.11 2.65 N/A N/A N/A
rs699937 XPO5 6 Zhang X, 2010 [38] CC + CT 127 (32.2) 267 (67.7) 1    N/A N/A N/A
TT 20 (43.5) 26 (56.5) 1.71 1.06 2.77 N/A N/A N/A
rs7118388 CAT 11 Wu X, 2009 [36 G > A 51/66/30* 70/139/84* 0.67 0.53 0.84 N/A N/A N/A
rs7168671 IGF1R 15 Wu X, 2009 [36] C > T 94/44/9* 194/93/6* 3.98 1.87 8.44 N/A N/A N/A
rs7210080 SSTR2 17 Zhang X, 2010 [38] AA+AG 133 (32.2) 280 (67.8) 1    N/A N/A N/A
GG 14 (51.8) 13 (48.2) 1.88 1.07 3.31 N/A N/A N/A
rs739999 RGS11 16 Wang J, 2010 [24] AA 113 (77.4) 242 (82.6) 1    N/A N/A N/A
AG 28 (19.2) 47 (16.0) 1.16 0.76 1.77 N/A N/A N/A
GG 5 (3.4) 4 (1.4) 2.99 1.10 8.13 N/A N/A N/A
rs7561607 GLI2 2 Wu X, 2009 [36] C > T 26//82/39* 103/128/62* 2.3 1.49 3.55 N/A N/A N/A
rs7591 AXIN1 16 Wu X, 2009 [36] A > T 33/93/21* 110/124/59* 2.03 1.37 3.01 N/A N/A N/A
rs7719666 RNASEN 5 Zhang X, 2010 [38] TT 46 (39.3) 71 (60.7) 1    N/A N/A N/A
CT 73 (34.6) 138 (65.4) 0.87 0.60 1.27 N/A N/A N/A
CC 28 (25.0) 84 (75.0) 0.59 0.37 0.95 N/A N/A N/A
rs7735863 RNASEN 5 Zhang X, 2010 [38] AA 111 (31.1) 246 (68.9) 1    N/A N/A N/A
AG + GG 36 (43.4) 47 (56.6) 1.72 1.16 2.57 N/A N/A N/A
rs7781436 CDK6 7 Wu X, 2009 [36] T > C 97/41/9* 186/104/3* 4.51 2.22 9.17 N/A N/A N/A
rs876435 TNFRSF10B 8 Wu X, 2009 [36] A > G 51/63/33* 114/148/31* 2.26 1.52 3.36 N/A N/A N/A
rs9562605 BRCA2 13 Wu X, 2009 [36] C > T 107/36/4* 168/124/6* 0.54 0.37 0.78 N/A N/A N/A
rs9622978 PDGFB 22 Wu X, 2009 [36] G > T 49/63/35* 98/160/35* 1.92 1.3 2.85 N/A N/A N/A
GPX1 ALA GPX1 3 Jefferies S, 2005 [42] ALA5/ALA5 7 (11.2) NR N/A N/A N/A 0.46 0.20 1.07
ALA5/ALA6 15 (23.8) NR N/A N/A N/A 0.78 0.41 1.48
ALA5/ALA7 19 (30.1) NR N/A N/A N/A 1.43 0.78 2.63
ALA6/ALA6 5 (7.9) NR N/A N/A N/A 0.93 0.34 2.56
ALA6/ALA7 15 (23.8) NR N/A N/A N/A 2.07 1.05 4.10
ALA7/ALA7 2 (3.2) NR N/A N/A N/A 0.57 0.13 2.57
  1. Abbreviations: SNP Single Nucleotide Polymorphisms, SPC Second primary cancer, NA Not applicable, NR Nor reported, HR Hazard Ratio, OR Odds Ratio, UCI upper confidence interval, LCI low confidence interval, * common homozygous/ heterozygous/rare homozygous genotype; in bold are reported statistically significant data