|
SNP
|
Genes investigated
|
Chromosome
|
Author, year [Ref]
|
Genotype
|
SPC/recurrence Yes, n (%)
|
No, n (%)
|
HR
|
LCI
|
UCI
|
OR
|
LCI
|
UCI
|
|---|
|
rs1042891 C > T
|
CASP6
|
4
|
Guan X, 2013 [26]
|
CC
|
480 (44.8)
|
462 (43.5)
|
N/A
|
N/A
|
N/A
|
1
| | |
|
CT
|
453 (42.5)
|
473 (43.7)
|
N/A
|
N/A
|
N/A
|
0.92
|
0.77
|
1.12
|
|
TT
|
132 (12.4)
|
137 (12.8)
|
N/A
|
N/A
|
N/A
|
0.91
|
0.69
|
1.21
|
|
CT/TT
|
592 (54.9)
|
610 (56.5)
|
N/A
|
N/A
|
N/A
|
0.93
|
0.77
|
1.11
|
|
rs1049216 A > G
|
CASP3
|
4
|
Guan X, 2013 [26]
|
AA
|
581 (54.5)
|
542 (50.5)
|
N/A
|
N/A
|
N/A
|
1
| | |
|
AG
|
401 (37.6)
|
441 (41.0)
|
N/A
|
N/A
|
N/A
|
0.83
|
0.68
|
1.00
|
|
GG
|
84 (7.9)
|
91 (8.5)
|
N/A
|
N/A
|
N/A
|
0.86
|
0.62
|
1.20
|
|
AG/GG
|
485 (45.5)
|
532 (49.5)
|
N/A
|
N/A
|
N/A
|
0.83
|
0.70
|
0.99
|
|
rs1049253 T > C
|
CASP3
|
4
|
Guan X, 2013 [26]
|
TT
|
669 (62.8)
|
734 (68.3)
|
N/A
|
N/A
|
N/A
|
1
| | |
|
TC
|
346 (32.4)
|
306 (28.5)
|
N/A
|
N/A
|
N/A
|
1.24
|
1.02
|
1.15
|
|
CC
|
51 (4.8)
|
34 (3.2)
|
N/A
|
N/A
|
N/A
|
1.80
|
1.13
|
2.87
|
|
TC/CC
|
397 (37.2)
|
340 (31.7)
|
N/A
|
N/A
|
N/A
|
1.29
|
1.07
|
1.56
|
|
rs10787498 T > G
|
CASP7
|
10
|
Guan X, 2013 [26]
|
TT
|
466 (43.9)
|
470 (43.9)
|
N/A
|
N/A
|
N/A
|
1
| | |
|
GT
|
482 (45.4)
|
486 (45.4)
|
N/A
|
N/A
|
N/A
|
1.03
|
0.85
|
1.24
|
|
GG
|
114 (10.7)
|
115(10.7)
|
N/A
|
N/A
|
N/A
|
0.93
|
0.69
|
1.26
|
|
GT/GG
|
596 (56.1)
|
601 (56.1)
|
N/A
|
N/A
|
N/A
|
1.01
|
0.84
|
1.20
|
|
rs11047917
|
KRAS
|
12
|
Wu X, 2009 [36]
|
C > T
|
123/24/0
|
271/22/0
|
2.12
|
1.36
|
3.31
|
N/A
|
N/A
|
N/A
|
|
rs11061209
|
RAN
|
12
|
Zhang X, 2010 [38]
|
AA+AG
|
123 (32.2)
|
259 (67.8)
|
1
| | |
N/A
|
N/A
|
N/A
|
|
GG
|
24 (41.4)
|
34 (58.6)
|
1.6
|
1.02
|
2.49
|
N/A
|
N/A
|
N/A
|
|
rs1127687 G > A
|
CASP7
|
10
|
Guan X, 2013 [26]
|
GG
|
613 (57.5)
|
635 (59.1)
|
N/A
|
N/A
|
N/A
|
1
| | |
|
AG
|
407 (38.2)
|
381 (35.5)
|
N/A
|
N/A
|
N/A
|
1.09
|
0.9
|
1.31
|
|
AA
|
46 (4.3)
|
58 (5.4)
|
N/A
|
N/A
|
N/A
|
0.8
|
0.52
|
1.21
|
|
AG/AA
|
453 (42.5)
|
439 (40.9)
|
N/A
|
N/A
|
N/A
|
1.05
|
0.88
|
1.26
|
|
rs11586945
|
RGS5
|
1
|
Wang J, 2010 [24]
|
GG
|
96 (65.3)
|
206 (70.3)
|
1
| | |
N/A
|
N/A
|
N/A
|
|
GC
|
41 (27.9)
|
76 (25.9)
|
1.11
|
0.77
|
1.62
|
N/A
|
N/A
|
N/A
|
|
CC
|
10 (6.8)
|
11 (3.7)
|
2.06
|
1.06
|
3.99
|
N/A
|
N/A
|
N/A
|
|
rs11594179
|
SUFU
|
10
|
Zhang X, 2010 [38]
|
GG
|
103 (37.4)
|
172 (62.5)
|
1
| | |
N/A
|
N/A
|
N/A
|
|
AG + AA
|
44 (26.7)
|
121 (73.3)
|
0.67
|
0.47
|
0.96
|
N/A
|
N/A
|
N/A
|
|
AA
|
838 (78.1)
|
827 (77.1)
|
N/A
|
N/A
|
N/A
|
1
| | |
|
rs12247479 A > G
|
CASP7
|
10
|
Guan X, 2013 [26]
|
AG
|
219 (20.6)
|
228 (21.2)
|
N/A
|
N/A
|
N/A
|
0.95
|
0.76
|
1.18
|
|
GG
|
14 (1.3)
|
18 (1.7)
|
N/A
|
N/A
|
N/A
|
0.68
|
0.32
|
1.41
|
|
AG/GG
|
233 (21.9)
|
246 (22.9)
|
N/A
|
N/A
|
N/A
|
0.93
|
0.75
|
1.15
|
|
rs12359892
|
MKI67
|
10
|
Wu X, 2009 [36]
|
T > C
|
101/14/27
|
221/38/18
|
2.65
|
4.11
|
1.72
|
N/A
|
N/A
|
N/A
|
|
rs12888332
|
MNAT1
|
14
|
Wu X, 2009 [36]
|
T > G
|
125/19/3
|
280/10/3
|
2.57
|
1.62
|
4.09
|
N/A
|
N/A
|
N/A
|
|
rs15864
|
GSTM3
|
1
|
Zhang X, 2010 [38]
|
GG + GC
|
127 (35.2)
|
234 (64.8)
|
1
| | |
N/A
|
N/A
|
N/A
|
|
CC
|
8 (20.0)
|
32 (80.0)
|
0.49
|
0.24
|
1.00
|
N/A
|
N/A
|
N/A
|
|
rs17387169
|
PROM1
|
4
|
Wu X, 2009 [36]
|
G > A
|
129/19/2
|
202/85/6
|
0.42
|
0.26
|
0.67
|
N/A
|
N/A
|
N/A
|
|
rs17410035
|
RNASEN
|
5
|
Zhang X, 2010 [38]
|
CC + AC
|
141 (35.7)
|
254 (64.3)
|
1
| | |
N/A
|
N/A
|
N/A
|
|
AA
|
6 (13.6)
|
38 (86.4)
|
0.36
|
0.16
|
0.83
|
N/A
|
N/A
|
N/A
|
|
rs1884056
|
BCL2L2
|
14
|
Zhang X, 2010 [38]
|
GG
|
59 (28.1)
|
151 (71.9)
|
1
| | |
N/A
|
N/A
|
N/A
|
|
AG
|
63 (36.2)
|
111 (63.8)
|
1.41
|
0.98
|
2.03
|
N/A
|
N/A
|
N/A
|
|
AA
|
25 (44.6)
|
31 (55.4)
|
1.85
|
1.14
|
3.01
|
N/A
|
N/A
|
N/A
|
|
rs2179653
|
RGS2
|
1
|
Wang J, 2010 [24]
|
GG
|
103 (70.1)
|
208 (70.9)
|
1
| | |
N/A
|
N/A
|
N/A
|
|
GA
|
34 (23.1)
|
81 (27.6)
|
0.97
|
0.65
|
1.44
|
N/A
|
N/A
|
N/A
|
|
AA
|
10 (6.8)
|
4 (1.4)
|
2.93
|
1.50
|
5.73
|
N/A
|
N/A
|
N/A
|
|
rs2227301
|
XPO5
|
6
|
Zhang X, 2010 [38]
|
GG+ AG
|
136 (32.6)
|
281 (67.4)
|
1
| | |
N/A
|
N/A
|
N/A
|
|
AA
|
11 (47.8)
|
12 (52.2)
|
1.91
|
1.02
|
3.58
|
N/A
|
N/A
|
N/A
|
|
rs2237724
|
CFTR
|
7
|
Wu X, 2009 [36]
|
G > A
|
92/45/10*
|
198/89/6*
|
3.12
|
1.62
|
5.98
|
N/A
|
N/A
|
N/A
|
|
rs2300181
|
CAT
|
11
|
Wu X, 2009 [36]
|
G > A
|
76/58/13*
|
163/124/6*
|
2.67
|
1.49
|
4.78
|
N/A
|
N/A
|
N/A
|
|
rs2306536
|
CHFR
|
12
|
Wu X, 2009 [36]
|
G > A
|
87/49/11*
|
88/97/8*
|
3.14
|
1.65
|
5.99
|
N/A
|
N/A
|
N/A
|
|
rs359974
|
NHEJ1
|
2
|
Wu X, 2009 [36]
|
T > C
|
93/44/10*
|
213/76/4*
|
4.26
|
2.18
|
8.32
|
N/A
|
N/A
|
N/A
|
|
rs3732360
|
NR1I2
|
3
|
Zhang X, 2010 [38]
|
AA
|
63 (28.8)
|
156 (71.2)
|
1
| | |
N/A
|
N/A
|
N/A
|
|
AG
|
67 (36.6)
|
116 (63.4)
|
1.29
|
0.91
|
1.83
|
N/A
|
N/A
|
N/A
|
|
GG
|
17 (44.7)
|
21 (55.3)
|
1.96
|
1.12
|
3.44
|
N/A
|
N/A
|
N/A
|
|
rs3747238
|
SMC1B
|
22
|
Zhang X, 2010 [38]
|
AA+AG
|
108 (31.1)
|
239 (68.8)
|
1
| | |
N/A
|
N/A
|
N/A
|
|
GG
|
39 (41.9)
|
54 (58.1)
|
1.74
|
1.19
|
2.54
|
N/A
|
N/A
|
N/A
|
|
rs3747813
|
RGS3
|
9
|
Wang J, 2010 [24]
|
GG
|
136 (92.5)
|
258 (88.1)
|
1
| | |
N/A
|
N/A
|
N/A
|
|
GA
|
11 (7.4)
|
34 (11.6)
|
0.54
|
0.29
|
1.02
|
N/A
|
N/A
|
N/A
|
|
AA
|
0
|
1 (0.3)
|
_
| | |
N/A
|
N/A
|
N/A
|
|
rs3792830
|
RNASEN
|
5
|
Zhang X, 2010 [38]
|
TT
|
126 (31.9)
|
269 (68.1)
|
1
| | |
N/A
|
N/A
|
N/A
|
|
TC + CC
|
21 (46.7)
|
24 (53.3)
|
1.75
|
1.08
|
2.82
|
N/A
|
N/A
|
N/A
|
|
rs3795617
|
RGS13
|
1
|
Wang J, 2010 [24]
|
GG
|
42 (28.6)
|
87 (29.7)
|
1
| | |
N/A
|
N/A
|
N/A
|
|
GA
|
80 (54.4)
|
119 (40.6)
|
1.18
|
0.81
|
1.72
|
N/A
|
N/A
|
N/A
|
|
AA
|
25 (17.0)
|
87 (29.7)
|
0.58
|
0.35
|
0.96
|
N/A
|
N/A
|
N/A
|
|
rs3805500
|
RNASEN
|
5
|
Zhang X, 2010 [38]
|
CC
|
49 (25.8)
|
141 (74.2)
|
1
| | |
N/A
|
N/A
|
N/A
|
|
CT
|
69 (37.7)
|
114 (62.3)
|
1.52
|
1.05
|
2.20
|
N/A
|
N/A
|
N/A
|
|
TT
|
22 (44.0)
|
28 (56.0)
|
1.91
|
1.13
|
3.23
|
N/A
|
N/A
|
N/A
|
|
rs3826537
|
MRC2
|
17
|
Wu X, 2009 [36]
|
A > G
|
67/63/17*
|
88/150/55*
|
0.57
|
0.41
|
0.79
|
N/A
|
N/A
|
N/A
|
|
rs3917328
|
IL1R1
|
2
|
Zhang X, 2010 [38]
|
GG
|
131 (32.6)
|
271 (67.4)
|
1
| | |
N/A
|
N/A
|
N/A
|
|
AG + AA
|
16 (42.1)
|
22 (57.9)
|
1.8
|
1.05
|
3.07
|
N/A
|
N/A
|
N/A
|
|
rs4353229 T > C
|
CASP7
|
10
|
Guan X, 2013 [26]
|
TT
|
611 (57.4)
|
614 (57.2)
|
N/A
|
N/A
|
N/A
|
1
| | |
|
CT
|
387 (36.4)
|
403 (37.5)
|
N/A
|
N/A
|
N/A
|
1.03
|
0.86
|
1.25
|
|
CC
|
66 (6.2)
|
57 (5.3)
|
N/A
|
N/A
|
N/A
|
1.22
|
0.82
|
1.78
|
|
CT/CC
|
453 (42.6)
|
460 (42.8)
|
N/A
|
N/A
|
N/A
|
1.06
|
0.88
|
1.26
|
|
rs506008
|
GSTM4
|
1
|
Wu X, 2009 [36]
|
G > A
|
94/46/3*
|
232/54/1*
|
2.09
|
1.46
|
3.00
|
N/A
|
N/A
|
N/A
|
|
rs604337
|
GSTM4
|
1
|
Wu X, 2009 [36]
|
C > T
|
94/50/3*
|
223/64/6*
|
1.84
|
1.29
|
2.61
|
N/A
|
N/A
|
N/A
|
|
rs639174
|
RNASEN
|
5
|
Zhang X, 2010 [38]
|
CC + CT
|
132 (32.4)
|
276 (67.6)
|
1
| | |
N/A
|
N/A
|
N/A
|
|
TT
|
15 (48.4)
|
16 (51.6)
|
1.88
|
1.09
|
3.25
|
N/A
|
N/A
|
N/A
|
|
rs6670735
|
RGS8
|
1
|
Wang J, 2010 [24]
|
AA
|
68 (46.3)
|
111 (38.0)
|
1
| | |
N/A
|
N/A
|
N/A
|
|
AG
|
58 (39.5)
|
147 (50.3)
|
0.64
|
0.45
|
0.92
|
N/A
|
N/A
|
N/A
|
|
GG
|
21 (14.3)
|
34 (11.6)
|
0.86
|
0.52
|
1.42
|
N/A
|
N/A
|
N/A
|
|
rs6684195
|
RNF2
|
1
|
Wu X, 2009 [36]
|
A > G
|
50/64/33*
|
111/150/32*
|
2.12
|
1.43
|
3.14
|
N/A
|
N/A
|
N/A
|
|
rs6689169
|
RGS7
|
1
|
Wang J, 2010 [24]
|
AA
|
120 (81.6)
|
211 (72.0)
|
1
| | |
N/A
|
N/A
|
N/A
|
|
AG
|
24 (16.3)
|
79 (26.9)
|
0.6
|
0.38
|
0.94
|
N/A
|
N/A
|
N/A
|
|
GG
|
3 (2.0)
|
3 (1.0)
|
1.65
|
0.52
|
5.24
|
N/A
|
N/A
|
N/A
|
|
rs669702
|
RNASEN
|
5
|
Zhang X, 2010 [38]
|
GG
|
112 (31.5)
|
243 (68.4)
|
1
| | |
N/A
|
N/A
|
N/A
|
|
GA + AA
|
35 (41.2)
|
50 (58.8)
|
1.53
|
1.04
|
2.26
|
N/A
|
N/A
|
N/A
|
|
rs6884823
|
RNASEN
|
5
|
Zhang X, 2010 [38]
|
GG
|
120 (31.5)
|
261 (68.5)
|
1
| | |
N/A
|
N/A
|
N/A
|
|
GA + AA
|
27 (45.7)
|
32 (54.3)
|
1.71
|
1.11
|
2.65
|
N/A
|
N/A
|
N/A
|
|
rs699937
|
XPO5
|
6
|
Zhang X, 2010 [38]
|
CC + CT
|
127 (32.2)
|
267 (67.7)
|
1
| | |
N/A
|
N/A
|
N/A
|
|
TT
|
20 (43.5)
|
26 (56.5)
|
1.71
|
1.06
|
2.77
|
N/A
|
N/A
|
N/A
|
|
rs7118388
|
CAT
|
11
|
Wu X, 2009 [36]
|
G > A
|
51/66/30*
|
70/139/84*
|
0.67
|
0.53
|
0.84
|
N/A
|
N/A
|
N/A
|
|
rs7168671
|
IGF1R
|
15
|
Wu X, 2009 [36]
|
C > T
|
94/44/9*
|
194/93/6*
|
3.98
|
1.87
|
8.44
|
N/A
|
N/A
|
N/A
|
|
rs7210080
|
SSTR2
|
17
|
Zhang X, 2010 [38]
|
AA+AG
|
133 (32.2)
|
280 (67.8)
|
1
| | |
N/A
|
N/A
|
N/A
|
|
GG
|
14 (51.8)
|
13 (48.2)
|
1.88
|
1.07
|
3.31
|
N/A
|
N/A
|
N/A
|
|
rs739999
|
RGS11
|
16
|
Wang J, 2010 [24]
|
AA
|
113 (77.4)
|
242 (82.6)
|
1
| | |
N/A
|
N/A
|
N/A
|
|
AG
|
28 (19.2)
|
47 (16.0)
|
1.16
|
0.76
|
1.77
|
N/A
|
N/A
|
N/A
|
|
GG
|
5 (3.4)
|
4 (1.4)
|
2.99
|
1.10
|
8.13
|
N/A
|
N/A
|
N/A
|
|
rs7561607
|
GLI2
|
2
|
Wu X, 2009 [36]
|
C > T
|
26//82/39*
|
103/128/62*
|
2.3
|
1.49
|
3.55
|
N/A
|
N/A
|
N/A
|
|
rs7591
|
AXIN1
|
16
|
Wu X, 2009 [36]
|
A > T
|
33/93/21*
|
110/124/59*
|
2.03
|
1.37
|
3.01
|
N/A
|
N/A
|
N/A
|
|
rs7719666
|
RNASEN
|
5
|
Zhang X, 2010 [38]
|
TT
|
46 (39.3)
|
71 (60.7)
|
1
| | |
N/A
|
N/A
|
N/A
|
|
CT
|
73 (34.6)
|
138 (65.4)
|
0.87
|
0.60
|
1.27
|
N/A
|
N/A
|
N/A
|
|
CC
|
28 (25.0)
|
84 (75.0)
|
0.59
|
0.37
|
0.95
|
N/A
|
N/A
|
N/A
|
|
rs7735863
|
RNASEN
|
5
|
Zhang X, 2010 [38]
|
AA
|
111 (31.1)
|
246 (68.9)
|
1
| | |
N/A
|
N/A
|
N/A
|
|
AG + GG
|
36 (43.4)
|
47 (56.6)
|
1.72
|
1.16
|
2.57
|
N/A
|
N/A
|
N/A
|
|
rs7781436
|
CDK6
|
7
|
Wu X, 2009 [36]
|
T > C
|
97/41/9*
|
186/104/3*
|
4.51
|
2.22
|
9.17
|
N/A
|
N/A
|
N/A
|
|
rs876435
|
TNFRSF10B
|
8
|
Wu X, 2009 [36]
|
A > G
|
51/63/33*
|
114/148/31*
|
2.26
|
1.52
|
3.36
|
N/A
|
N/A
|
N/A
|
|
rs9562605
|
BRCA2
|
13
|
Wu X, 2009 [36]
|
C > T
|
107/36/4*
|
168/124/6*
|
0.54
|
0.37
|
0.78
|
N/A
|
N/A
|
N/A
|
|
rs9622978
|
PDGFB
|
22
|
Wu X, 2009 [36]
|
G > T
|
49/63/35*
|
98/160/35*
|
1.92
|
1.3
|
2.85
|
N/A
|
N/A
|
N/A
|
|
GPX1 ALA
|
GPX1
|
3
|
Jefferies S, 2005 [42]
|
ALA5/ALA5
|
7 (11.2)
|
NR
|
N/A
|
N/A
|
N/A
|
0.46
|
0.20
|
1.07
|
|
ALA5/ALA6
|
15 (23.8)
|
NR
|
N/A
|
N/A
|
N/A
|
0.78
|
0.41
|
1.48
|
|
ALA5/ALA7
|
19 (30.1)
|
NR
|
N/A
|
N/A
|
N/A
|
1.43
|
0.78
|
2.63
|
|
ALA6/ALA6
|
5 (7.9)
|
NR
|
N/A
|
N/A
|
N/A
|
0.93
|
0.34
|
2.56
|
|
ALA6/ALA7
|
15 (23.8)
|
NR
|
N/A
|
N/A
|
N/A
|
2.07
|
1.05
|
4.10
|
|
ALA7/ALA7
|
2 (3.2)
|
NR
|
N/A
|
N/A
|
N/A
|
0.57
|
0.13
|
2.57
|
- Abbreviations: SNP Single Nucleotide Polymorphisms, SPC Second primary cancer, NA Not applicable, NR Nor reported, HR Hazard Ratio, OR Odds Ratio, UCI upper confidence interval, LCI low confidence interval, * common homozygous/ heterozygous/rare homozygous genotype; in bold are reported statistically significant data
