Table 3 Associations of SNPs with second primary cancer risk in five case-control studies included in systematic review

rs1042891 C > T

CASP6

4

Guan X, 2013 [26]

CC

480 (44.8)

462 (43.5)

N/A

N/A

N/A

1

CT

453 (42.5)

473 (43.7)

N/A

N/A

N/A

0.92

0.77

1.12

TT

132 (12.4)

137 (12.8)

N/A

N/A

N/A

0.91

0.69

1.21

CT/TT

592 (54.9)

610 (56.5)

N/A

N/A

N/A

0.93

0.77

1.11

rs1049216 A > G

CASP3

4

Guan X, 2013 [26]

AA

581 (54.5)

542 (50.5)

N/A

N/A

N/A

1

AG

401 (37.6)

441 (41.0)

N/A

N/A

N/A

0.83

0.68

1.00

GG

84 (7.9)

91 (8.5)

N/A

N/A

N/A

0.86

0.62

1.20

AG/GG

485 (45.5)

532 (49.5)

N/A

N/A

N/A

0.83

0.70

0.99

rs1049253 T > C

CASP3

4

Guan X, 2013 [26]

TT

669 (62.8)

734 (68.3)

N/A

N/A

N/A

1

TC

346 (32.4)

306 (28.5)

N/A

N/A

N/A

1.24

1.02

1.15

CC

51 (4.8)

34 (3.2)

N/A

N/A

N/A

1.80

1.13

2.87

TC/CC

397 (37.2)

340 (31.7)

N/A

N/A

N/A

1.29

1.07

1.56

rs10787498 T > G

CASP7

10

Guan X, 2013 [26]

TT

466 (43.9)

470 (43.9)

N/A

N/A

N/A

1

GT

482 (45.4)

486 (45.4)

N/A

N/A

N/A

1.03

0.85

1.24

GG

114 (10.7)

115(10.7)

N/A

N/A

N/A

0.93

0.69

1.26

GT/GG

596 (56.1)

601 (56.1)

N/A

N/A

N/A

1.01

0.84

1.20

rs11047917

KRAS

12

Wu X, 2009 [36]

C > T

123/24/0

271/22/0

2.12

1.36

3.31

N/A

N/A

N/A

rs11061209

RAN

12

Zhang X, 2010 [38]

AA+AG

123 (32.2)

259 (67.8)

1

N/A

N/A

N/A

GG

24 (41.4)

34 (58.6)

1.6

1.02

2.49

N/A

N/A

N/A

rs1127687 G > A

CASP7

10

Guan X, 2013 [26]

GG

613 (57.5)

635 (59.1)

N/A

N/A

N/A

1

AG

407 (38.2)

381 (35.5)

N/A

N/A

N/A

1.09

0.9

1.31

AA

46 (4.3)

58 (5.4)

N/A

N/A

N/A

0.8

0.52

1.21

AG/AA

453 (42.5)

439 (40.9)

N/A

N/A

N/A

1.05

0.88

1.26

rs11586945

RGS5

1

Wang J, 2010 [24]

GG

96 (65.3)

206 (70.3)

1

N/A

N/A

N/A

GC

41 (27.9)

76 (25.9)

1.11

0.77

1.62

N/A

N/A

N/A

CC

10 (6.8)

11 (3.7)

2.06

1.06

3.99

N/A

N/A

N/A

rs11594179

SUFU

10

Zhang X, 2010 [38]

GG

103 (37.4)

172 (62.5)

1

N/A

N/A

N/A

AG + AA

44 (26.7)

121 (73.3)

0.67

0.47

0.96

N/A

N/A

N/A

AA

838 (78.1)

827 (77.1)

N/A

N/A

N/A

1

rs12247479 A > G

CASP7

10

Guan X, 2013 [26]

AG

219 (20.6)

228 (21.2)

N/A

N/A

N/A

0.95

0.76

1.18

GG

14 (1.3)

18 (1.7)

N/A

N/A

N/A

0.68

0.32

1.41

AG/GG

233 (21.9)

246 (22.9)

N/A

N/A

N/A

0.93

0.75

1.15

rs12359892

MKI67

10

Wu X, 2009 [36]

T > C

101/14/27

221/38/18

2.65

4.11

1.72

N/A

N/A

N/A

rs12888332

MNAT1

14

Wu X, 2009 [36]

T > G

125/19/3

280/10/3

2.57

1.62

4.09

N/A

N/A

N/A

rs15864

GSTM3

1

Zhang X, 2010 [38]

GG + GC

127 (35.2)

234 (64.8)

1

N/A

N/A

N/A

CC

8 (20.0)

32 (80.0)

0.49

0.24

1.00

N/A

N/A

N/A

rs17387169

PROM1

4

Wu X, 2009 [36]

G > A

129/19/2

202/85/6

0.42

0.26

0.67

N/A

N/A

N/A

rs17410035

RNASEN

5

Zhang X, 2010 [38]

CC + AC

141 (35.7)

254 (64.3)

1

N/A

N/A

N/A

AA

6 (13.6)

38 (86.4)

0.36

0.16

0.83

N/A

N/A

N/A

rs1884056

BCL2L2

14

Zhang X, 2010 [38]

GG

59 (28.1)

151 (71.9)

1

N/A

N/A

N/A

AG

63 (36.2)

111 (63.8)

1.41

0.98

2.03

N/A

N/A

N/A

AA

25 (44.6)

31 (55.4)

1.85

1.14

3.01

N/A

N/A

N/A

rs2179653

RGS2

1

Wang J, 2010 [24]

GG

103 (70.1)

208 (70.9)

1

N/A

N/A

N/A

GA

34 (23.1)

81 (27.6)

0.97

0.65

1.44

N/A

N/A

N/A

AA

10 (6.8)

4 (1.4)

2.93

1.50

5.73

N/A

N/A

N/A

rs2227301

XPO5

6

Zhang X, 2010 [38]

GG+ AG

136 (32.6)

281 (67.4)

1

N/A

N/A

N/A

AA

11 (47.8)

12 (52.2)

1.91

1.02

3.58

N/A

N/A

N/A

rs2237724

CFTR

7

Wu X, 2009 [36]

G > A

92/45/10*

198/89/6*

3.12

1.62

5.98

N/A

N/A

N/A

rs2300181

CAT

11

Wu X, 2009 [36]

G > A

76/58/13*

163/124/6*

2.67

1.49

4.78

N/A

N/A

N/A

rs2306536

CHFR

12

Wu X, 2009 [36]

G > A

87/49/11*

88/97/8*

3.14

1.65

5.99

N/A

N/A

N/A

rs359974

NHEJ1

2

Wu X, 2009 [36]

T > C

93/44/10*

213/76/4*

4.26

2.18

8.32

N/A

N/A

N/A

rs3732360

NR1I2

3

Zhang X, 2010 [38]

AA

63 (28.8)

156 (71.2)

1

N/A

N/A

N/A

AG

67 (36.6)

116 (63.4)

1.29

0.91

1.83

N/A

N/A

N/A

GG

17 (44.7)

21 (55.3)

1.96

1.12

3.44

N/A

N/A

N/A

rs3747238

SMC1B

22

Zhang X, 2010 [38]

AA+AG

108 (31.1)

239 (68.8)

1

N/A

N/A

N/A

GG

39 (41.9)

54 (58.1)

1.74

1.19

2.54

N/A

N/A

N/A

rs3747813

RGS3

9

Wang J, 2010 [24]

GG

136 (92.5)

258 (88.1)

1

N/A

N/A

N/A

GA

11 (7.4)

34 (11.6)

0.54

0.29

1.02

N/A

N/A

N/A

AA

0

1 (0.3)

_

N/A

N/A

N/A

rs3792830

RNASEN

5

Zhang X, 2010 [38]

TT

126 (31.9)

269 (68.1)

1

N/A

N/A

N/A

TC + CC

21 (46.7)

24 (53.3)

1.75

1.08

2.82

N/A

N/A

N/A

rs3795617

RGS13

1

Wang J, 2010 [24]

GG

42 (28.6)

87 (29.7)

1

N/A

N/A

N/A

GA

80 (54.4)

119 (40.6)

1.18

0.81

1.72

N/A

N/A

N/A

AA

25 (17.0)

87 (29.7)

0.58

0.35

0.96

N/A

N/A

N/A

rs3805500

RNASEN

5

Zhang X, 2010 [38]

CC

49 (25.8)

141 (74.2)

1

N/A

N/A

N/A

CT

69 (37.7)

114 (62.3)

1.52

1.05

2.20

N/A

N/A

N/A

TT

22 (44.0)

28 (56.0)

1.91

1.13

3.23

N/A

N/A

N/A

rs3826537

MRC2

17

Wu X, 2009 [36]

A > G

67/63/17*

88/150/55*

0.57

0.41

0.79

N/A

N/A

N/A

rs3917328

IL1R1

2

Zhang X, 2010 [38]

GG

131 (32.6)

271 (67.4)

1

N/A

N/A

N/A

AG + AA

16 (42.1)

22 (57.9)

1.8

1.05

3.07

N/A

N/A

N/A

rs4353229 T > C

CASP7

10

Guan X, 2013 [26]

TT

611 (57.4)

614 (57.2)

N/A

N/A

N/A

1

CT

387 (36.4)

403 (37.5)

N/A

N/A

N/A

1.03

0.86

1.25

CC

66 (6.2)

57 (5.3)

N/A

N/A

N/A

1.22

0.82

1.78

CT/CC

453 (42.6)

460 (42.8)

N/A

N/A

N/A

1.06

0.88

1.26

rs506008

GSTM4

1

Wu X, 2009 [36]

G > A

94/46/3*

232/54/1*

2.09

1.46

3.00

N/A

N/A

N/A

rs604337

GSTM4

1

Wu X, 2009 [36]

C > T

94/50/3*

223/64/6*

1.84

1.29

2.61

N/A

N/A

N/A

rs639174

RNASEN

5

Zhang X, 2010 [38]

CC + CT

132 (32.4)

276 (67.6)

1

N/A

N/A

N/A

TT

15 (48.4)

16 (51.6)

1.88

1.09

3.25

N/A

N/A

N/A

rs6670735

RGS8

1

Wang J, 2010 [24]

AA

68 (46.3)

111 (38.0)

1

N/A

N/A

N/A

AG

58 (39.5)

147 (50.3)

0.64

0.45

0.92

N/A

N/A

N/A

GG

21 (14.3)

34 (11.6)

0.86

0.52

1.42

N/A

N/A

N/A

rs6684195

RNF2

1

Wu X, 2009 [36]

A > G

50/64/33*

111/150/32*

2.12

1.43

3.14

N/A

N/A

N/A

rs6689169

RGS7

1

Wang J, 2010 [24]

AA

120 (81.6)

211 (72.0)

1

N/A

N/A

N/A

AG

24 (16.3)

79 (26.9)

0.6

0.38

0.94

N/A

N/A

N/A

GG

3 (2.0)

3 (1.0)

1.65

0.52

5.24

N/A

N/A

N/A

rs669702

RNASEN

5

Zhang X, 2010 [38]

GG

112 (31.5)

243 (68.4)

1

N/A

N/A

N/A

GA + AA

35 (41.2)

50 (58.8)

1.53

1.04

2.26

N/A

N/A

N/A

rs6884823

RNASEN

5

Zhang X, 2010 [38]

GG

120 (31.5)

261 (68.5)

1

N/A

N/A

N/A

GA + AA

27 (45.7)

32 (54.3)

1.71

1.11

2.65

N/A

N/A

N/A

rs699937

XPO5

6

Zhang X, 2010 [38]

CC + CT

127 (32.2)

267 (67.7)

1

N/A

N/A

N/A

TT

20 (43.5)

26 (56.5)

1.71

1.06

2.77

N/A

N/A

N/A

rs7118388

CAT

11

Wu X, 2009 [36] 

G > A

51/66/30*

70/139/84*

0.67

0.53

0.84

N/A

N/A

N/A

rs7168671

IGF1R

15

Wu X, 2009 [36]

C > T

94/44/9*

194/93/6*

3.98

1.87

8.44

N/A

N/A

N/A

rs7210080

SSTR2

17

Zhang X, 2010 [38]

AA+AG

133 (32.2)

280 (67.8)

1

N/A

N/A

N/A

GG

14 (51.8)

13 (48.2)

1.88

1.07

3.31

N/A

N/A

N/A

rs739999

RGS11

16

Wang J, 2010 [24]

AA

113 (77.4)

242 (82.6)

1

N/A

N/A

N/A

AG

28 (19.2)

47 (16.0)

1.16

0.76

1.77

N/A

N/A

N/A

GG

5 (3.4)

4 (1.4)

2.99

1.10

8.13

N/A

N/A

N/A

rs7561607

GLI2

2

Wu X, 2009 [36]

C > T

26//82/39*

103/128/62*

2.3

1.49

3.55

N/A

N/A

N/A

rs7591

AXIN1

16

Wu X, 2009 [36]

A > T

33/93/21*

110/124/59*

2.03

1.37

3.01

N/A

N/A

N/A

rs7719666

RNASEN

5

Zhang X, 2010 [38]

TT

46 (39.3)

71 (60.7)

1

N/A

N/A

N/A

CT

73 (34.6)

138 (65.4)

0.87

0.60

1.27

N/A

N/A

N/A

CC

28 (25.0)

84 (75.0)

0.59

0.37

0.95

N/A

N/A

N/A

rs7735863

RNASEN

5

Zhang X, 2010 [38]

AA

111 (31.1)

246 (68.9)

1

N/A

N/A

N/A

AG + GG

36 (43.4)

47 (56.6)

1.72

1.16

2.57

N/A

N/A

N/A

rs7781436

CDK6

7

Wu X, 2009 [36]

T > C

97/41/9*

186/104/3*

4.51

2.22

9.17

N/A

N/A

N/A

rs876435

TNFRSF10B

8

Wu X, 2009 [36]

A > G

51/63/33*

114/148/31*

2.26

1.52

3.36

N/A

N/A

N/A

rs9562605

BRCA2

13

Wu X, 2009 [36]

C > T

107/36/4*

168/124/6*

0.54

0.37

0.78

N/A

N/A

N/A

rs9622978

PDGFB

22

Wu X, 2009 [36]

G > T

49/63/35*

98/160/35*

1.92

1.3

2.85

N/A

N/A

N/A

GPX1 ALA

GPX1

3

Jefferies S, 2005 [42]

ALA5/ALA5

7 (11.2)

NR

N/A

N/A

N/A

0.46

0.20

1.07

ALA5/ALA6

15 (23.8)

NR

N/A

N/A

N/A

0.78

0.41

1.48

ALA5/ALA7

19 (30.1)

NR

N/A

N/A

N/A

1.43

0.78

2.63

ALA6/ALA6

5 (7.9)

NR

N/A

N/A

N/A

0.93

0.34

2.56

ALA6/ALA7

15 (23.8)

NR

N/A

N/A

N/A

2.07

1.05

4.10

ALA7/ALA7

2 (3.2)

NR

N/A

N/A

N/A

0.57

0.13

2.57