SNP | Genes investigated | Chromosome | Author, year [Ref] | Genotype | SPC/recurrence Yes, n (%) | No, n (%) | HR | LCI | UCI | OR | LCI | UCI |
---|---|---|---|---|---|---|---|---|---|---|---|---|
rs1042891 C > T | CASP6 | 4 | Guan X, 2013 [26] | CC | 480 (44.8) | 462 (43.5) | N/A | N/A | N/A | 1 |  |  |
CT | 453 (42.5) | 473 (43.7) | N/A | N/A | N/A | 0.92 | 0.77 | 1.12 | ||||
TT | 132 (12.4) | 137 (12.8) | N/A | N/A | N/A | 0.91 | 0.69 | 1.21 | ||||
CT/TT | 592 (54.9) | 610 (56.5) | N/A | N/A | N/A | 0.93 | 0.77 | 1.11 | ||||
rs1049216 A > G | CASP3 | 4 | Guan X, 2013 [26] | AA | 581 (54.5) | 542 (50.5) | N/A | N/A | N/A | 1 |  |  |
AG | 401 (37.6) | 441 (41.0) | N/A | N/A | N/A | 0.83 | 0.68 | 1.00 | ||||
GG | 84 (7.9) | 91 (8.5) | N/A | N/A | N/A | 0.86 | 0.62 | 1.20 | ||||
AG/GG | 485 (45.5) | 532 (49.5) | N/A | N/A | N/A | 0.83 | 0.70 | 0.99 | ||||
rs1049253 T > C | CASP3 | 4 | Guan X, 2013 [26] | TT | 669 (62.8) | 734 (68.3) | N/A | N/A | N/A | 1 |  |  |
TC | 346 (32.4) | 306 (28.5) | N/A | N/A | N/A | 1.24 | 1.02 | 1.15 | ||||
CC | 51 (4.8) | 34 (3.2) | N/A | N/A | N/A | 1.80 | 1.13 | 2.87 | ||||
TC/CC | 397 (37.2) | 340 (31.7) | N/A | N/A | N/A | 1.29 | 1.07 | 1.56 | ||||
rs10787498 T > G | CASP7 | 10 | Guan X, 2013 [26] | TT | 466 (43.9) | 470 (43.9) | N/A | N/A | N/A | 1 |  |  |
GT | 482 (45.4) | 486 (45.4) | N/A | N/A | N/A | 1.03 | 0.85 | 1.24 | ||||
GG | 114 (10.7) | 115(10.7) | N/A | N/A | N/A | 0.93 | 0.69 | 1.26 | ||||
GT/GG | 596 (56.1) | 601 (56.1) | N/A | N/A | N/A | 1.01 | 0.84 | 1.20 | ||||
rs11047917 | KRAS | 12 | Wu X, 2009 [36] | C > T | 123/24/0 | 271/22/0 | 2.12 | 1.36 | 3.31 | N/A | N/A | N/A |
rs11061209 | RAN | 12 | Zhang X, 2010 [38] | AA+AG | 123 (32.2) | 259 (67.8) | 1 | Â | Â | N/A | N/A | N/A |
GG | 24 (41.4) | 34 (58.6) | 1.6 | 1.02 | 2.49 | N/A | N/A | N/A | ||||
rs1127687 G > A | CASP7 | 10 | Guan X, 2013 [26] | GG | 613 (57.5) | 635 (59.1) | N/A | N/A | N/A | 1 |  |  |
AG | 407 (38.2) | 381 (35.5) | N/A | N/A | N/A | 1.09 | 0.9 | 1.31 | ||||
AA | 46 (4.3) | 58 (5.4) | N/A | N/A | N/A | 0.8 | 0.52 | 1.21 | ||||
AG/AA | 453 (42.5) | 439 (40.9) | N/A | N/A | N/A | 1.05 | 0.88 | 1.26 | ||||
rs11586945 | RGS5 | 1 | Wang J, 2010 [24] | GG | 96 (65.3) | 206 (70.3) | 1 | Â | Â | N/A | N/A | N/A |
GC | 41 (27.9) | 76 (25.9) | 1.11 | 0.77 | 1.62 | N/A | N/A | N/A | ||||
CC | 10 (6.8) | 11 (3.7) | 2.06 | 1.06 | 3.99 | N/A | N/A | N/A | ||||
rs11594179 | SUFU | 10 | Zhang X, 2010 [38] | GG | 103 (37.4) | 172 (62.5) | 1 | Â | Â | N/A | N/A | N/A |
AG + AA | 44 (26.7) | 121 (73.3) | 0.67 | 0.47 | 0.96 | N/A | N/A | N/A | ||||
AA | 838 (78.1) | 827 (77.1) | N/A | N/A | N/A | 1 | Â | Â | ||||
rs12247479 A > G | CASP7 | 10 | Guan X, 2013 [26] | AG | 219 (20.6) | 228 (21.2) | N/A | N/A | N/A | 0.95 | 0.76 | 1.18 |
GG | 14Â (1.3) | 18Â (1.7) | N/A | N/A | N/A | 0.68 | 0.32 | 1.41 | ||||
AG/GG | 233 (21.9) | 246 (22.9) | N/A | N/A | N/A | 0.93 | 0.75 | 1.15 | ||||
rs12359892 | MKI67 | 10 | Wu X, 2009 [36] | T > C | 101/14/27 | 221/38/18 | 2.65 | 4.11 | 1.72 | N/A | N/A | N/A |
rs12888332 | MNAT1 | 14 | Wu X, 2009 [36] | T > G | 125/19/3 | 280/10/3 | 2.57 | 1.62 | 4.09 | N/A | N/A | N/A |
rs15864 | GSTM3 | 1 | Zhang X, 2010 [38] | GG + GC | 127 (35.2) | 234 (64.8) | 1 |  |  | N/A | N/A | N/A |
CC | 8 (20.0) | 32 (80.0) | 0.49 | 0.24 | 1.00 | N/A | N/A | N/A | ||||
rs17387169 | PROM1 | 4 | Wu X, 2009 [36] | G > A | 129/19/2 | 202/85/6 | 0.42 | 0.26 | 0.67 | N/A | N/A | N/A |
rs17410035 | RNASEN | 5 | Zhang X, 2010 [38] | CC + AC | 141 (35.7) | 254 (64.3) | 1 |  |  | N/A | N/A | N/A |
AA | 6 (13.6) | 38 (86.4) | 0.36 | 0.16 | 0.83 | N/A | N/A | N/A | ||||
rs1884056 | BCL2L2 | 14 | Zhang X, 2010 [38] | GG | 59 (28.1) | 151 (71.9) | 1 | Â | Â | N/A | N/A | N/A |
AG | 63 (36.2) | 111 (63.8) | 1.41 | 0.98 | 2.03 | N/A | N/A | N/A | ||||
AA | 25 (44.6) | 31 (55.4) | 1.85 | 1.14 | 3.01 | N/A | N/A | N/A | ||||
rs2179653 | RGS2 | 1 | Wang J, 2010 [24] | GG | 103 (70.1) | 208 (70.9) | 1 | Â | Â | N/A | N/A | N/A |
GA | 34 (23.1) | 81 (27.6) | 0.97 | 0.65 | 1.44 | N/A | N/A | N/A | ||||
AA | 10 (6.8) | 4 (1.4) | 2.93 | 1.50 | 5.73 | N/A | N/A | N/A | ||||
rs2227301 | XPO5 | 6 | Zhang X, 2010 [38] | GG+ AG | 136 (32.6) | 281 (67.4) | 1 | Â | Â | N/A | N/A | N/A |
AA | 11 (47.8) | 12 (52.2) | 1.91 | 1.02 | 3.58 | N/A | N/A | N/A | ||||
rs2237724 | CFTR | 7 | Wu X, 2009 [36] | G > A | 92/45/10* | 198/89/6* | 3.12 | 1.62 | 5.98 | N/A | N/A | N/A |
rs2300181 | CAT | 11 | Wu X, 2009 [36] | G > A | 76/58/13* | 163/124/6* | 2.67 | 1.49 | 4.78 | N/A | N/A | N/A |
rs2306536 | CHFR | 12 | Wu X, 2009 [36] | G > A | 87/49/11* | 88/97/8* | 3.14 | 1.65 | 5.99 | N/A | N/A | N/A |
rs359974 | NHEJ1 | 2 | Wu X, 2009 [36] | T > C | 93/44/10* | 213/76/4* | 4.26 | 2.18 | 8.32 | N/A | N/A | N/A |
rs3732360 | NR1I2 | 3 | Zhang X, 2010 [38] | AA | 63 (28.8) | 156 (71.2) | 1 | Â | Â | N/A | N/A | N/A |
AG | 67 (36.6) | 116 (63.4) | 1.29 | 0.91 | 1.83 | N/A | N/A | N/A | ||||
GG | 17 (44.7) | 21 (55.3) | 1.96 | 1.12 | 3.44 | N/A | N/A | N/A | ||||
rs3747238 | SMC1B | 22 | Zhang X, 2010 [38] | AA+AG | 108 (31.1) | 239 (68.8) | 1 | Â | Â | N/A | N/A | N/A |
GG | 39 (41.9) | 54 (58.1) | 1.74 | 1.19 | 2.54 | N/A | N/A | N/A | ||||
rs3747813 | RGS3 | 9 | Wang J, 2010 [24] | GG | 136 (92.5) | 258 (88.1) | 1 | Â | Â | N/A | N/A | N/A |
GA | 11 (7.4) | 34 (11.6) | 0.54 | 0.29 | 1.02 | N/A | N/A | N/A | ||||
AA | 0 | 1 (0.3) | _ | Â | Â | N/A | N/A | N/A | ||||
rs3792830 | RNASEN | 5 | Zhang X, 2010 [38] | TT | 126 (31.9) | 269 (68.1) | 1 | Â | Â | N/A | N/A | N/A |
TC + CC | 21 (46.7) | 24 (53.3) | 1.75 | 1.08 | 2.82 | N/A | N/A | N/A | ||||
rs3795617 | RGS13 | 1 | Wang J, 2010 [24] | GG | 42 (28.6) | 87 (29.7) | 1 | Â | Â | N/A | N/A | N/A |
GA | 80 (54.4) | 119 (40.6) | 1.18 | 0.81 | 1.72 | N/A | N/A | N/A | ||||
AA | 25 (17.0) | 87 (29.7) | 0.58 | 0.35 | 0.96 | N/A | N/A | N/A | ||||
rs3805500 | RNASEN | 5 | Zhang X, 2010 [38] | CC | 49 (25.8) | 141 (74.2) | 1 | Â | Â | N/A | N/A | N/A |
CT | 69 (37.7) | 114 (62.3) | 1.52 | 1.05 | 2.20 | N/A | N/A | N/A | ||||
TT | 22 (44.0) | 28 (56.0) | 1.91 | 1.13 | 3.23 | N/A | N/A | N/A | ||||
rs3826537 | MRC2 | 17 | Wu X, 2009 [36] | A > G | 67/63/17* | 88/150/55* | 0.57 | 0.41 | 0.79 | N/A | N/A | N/A |
rs3917328 | IL1R1 | 2 | Zhang X, 2010 [38] | GG | 131 (32.6) | 271 (67.4) | 1 | Â | Â | N/A | N/A | N/A |
AG + AA | 16 (42.1) | 22 (57.9) | 1.8 | 1.05 | 3.07 | N/A | N/A | N/A | ||||
rs4353229 T > C | CASP7 | 10 | Guan X, 2013 [26] | TT | 611 (57.4) | 614 (57.2) | N/A | N/A | N/A | 1 |  |  |
CT | 387 (36.4) | 403 (37.5) | N/A | N/A | N/A | 1.03 | 0.86 | 1.25 | ||||
CC | 66 (6.2) | 57 (5.3) | N/A | N/A | N/A | 1.22 | 0.82 | 1.78 | ||||
CT/CC | 453 (42.6) | 460 (42.8) | N/A | N/A | N/A | 1.06 | 0.88 | 1.26 | ||||
rs506008 | GSTM4 | 1 | Wu X, 2009 [36] | G > A | 94/46/3* | 232/54/1* | 2.09 | 1.46 | 3.00 | N/A | N/A | N/A |
rs604337 | GSTM4 | 1 | Wu X, 2009 [36] | C > T | 94/50/3* | 223/64/6* | 1.84 | 1.29 | 2.61 | N/A | N/A | N/A |
rs639174 | RNASEN | 5 | Zhang X, 2010 [38] | CC + CT | 132 (32.4) | 276 (67.6) | 1 |  |  | N/A | N/A | N/A |
TT | 15 (48.4) | 16 (51.6) | 1.88 | 1.09 | 3.25 | N/A | N/A | N/A | ||||
rs6670735 | RGS8 | 1 | Wang J, 2010 [24] | AA | 68 (46.3) | 111 (38.0) | 1 | Â | Â | N/A | N/A | N/A |
AG | 58 (39.5) | 147 (50.3) | 0.64 | 0.45 | 0.92 | N/A | N/A | N/A | ||||
GG | 21 (14.3) | 34 (11.6) | 0.86 | 0.52 | 1.42 | N/A | N/A | N/A | ||||
rs6684195 | RNF2 | 1 | Wu X, 2009 [36] | A > G | 50/64/33* | 111/150/32* | 2.12 | 1.43 | 3.14 | N/A | N/A | N/A |
rs6689169 | RGS7 | 1 | Wang J, 2010 [24] | AA | 120 (81.6) | 211 (72.0) | 1 | Â | Â | N/A | N/A | N/A |
AG | 24 (16.3) | 79 (26.9) | 0.6 | 0.38 | 0.94 | N/A | N/A | N/A | ||||
GG | 3 (2.0) | 3 (1.0) | 1.65 | 0.52 | 5.24 | N/A | N/A | N/A | ||||
rs669702 | RNASEN | 5 | Zhang X, 2010 [38] | GG | 112 (31.5) | 243 (68.4) | 1 | Â | Â | N/A | N/A | N/A |
GA + AA | 35 (41.2) | 50 (58.8) | 1.53 | 1.04 | 2.26 | N/A | N/A | N/A | ||||
rs6884823 | RNASEN | 5 | Zhang X, 2010 [38] | GG | 120 (31.5) | 261 (68.5) | 1 | Â | Â | N/A | N/A | N/A |
GA + AA | 27 (45.7) | 32 (54.3) | 1.71 | 1.11 | 2.65 | N/A | N/A | N/A | ||||
rs699937 | XPO5 | 6 | Zhang X, 2010 [38] | CC + CT | 127 (32.2) | 267 (67.7) | 1 |  |  | N/A | N/A | N/A |
TT | 20 (43.5) | 26 (56.5) | 1.71 | 1.06 | 2.77 | N/A | N/A | N/A | ||||
rs7118388 | CAT | 11 | Wu X, 2009 [36] | G > A | 51/66/30* | 70/139/84* | 0.67 | 0.53 | 0.84 | N/A | N/A | N/A |
rs7168671 | IGF1R | 15 | Wu X, 2009 [36] | C > T | 94/44/9* | 194/93/6* | 3.98 | 1.87 | 8.44 | N/A | N/A | N/A |
rs7210080 | SSTR2 | 17 | Zhang X, 2010 [38] | AA+AG | 133 (32.2) | 280 (67.8) | 1 | Â | Â | N/A | N/A | N/A |
GG | 14 (51.8) | 13 (48.2) | 1.88 | 1.07 | 3.31 | N/A | N/A | N/A | ||||
rs739999 | RGS11 | 16 | Wang J, 2010 [24] | AA | 113 (77.4) | 242 (82.6) | 1 | Â | Â | N/A | N/A | N/A |
AG | 28 (19.2) | 47 (16.0) | 1.16 | 0.76 | 1.77 | N/A | N/A | N/A | ||||
GG | 5 (3.4) | 4 (1.4) | 2.99 | 1.10 | 8.13 | N/A | N/A | N/A | ||||
rs7561607 | GLI2 | 2 | Wu X, 2009 [36] | C > T | 26//82/39* | 103/128/62* | 2.3 | 1.49 | 3.55 | N/A | N/A | N/A |
rs7591 | AXIN1 | 16 | Wu X, 2009 [36] | A > T | 33/93/21* | 110/124/59* | 2.03 | 1.37 | 3.01 | N/A | N/A | N/A |
rs7719666 | RNASEN | 5 | Zhang X, 2010 [38] | TT | 46 (39.3) | 71 (60.7) | 1 | Â | Â | N/A | N/A | N/A |
CT | 73 (34.6) | 138 (65.4) | 0.87 | 0.60 | 1.27 | N/A | N/A | N/A | ||||
CC | 28 (25.0) | 84 (75.0) | 0.59 | 0.37 | 0.95 | N/A | N/A | N/A | ||||
rs7735863 | RNASEN | 5 | Zhang X, 2010 [38] | AA | 111 (31.1) | 246 (68.9) | 1 | Â | Â | N/A | N/A | N/A |
AG + GG | 36 (43.4) | 47 (56.6) | 1.72 | 1.16 | 2.57 | N/A | N/A | N/A | ||||
rs7781436 | CDK6 | 7 | Wu X, 2009 [36] | T > C | 97/41/9* | 186/104/3* | 4.51 | 2.22 | 9.17 | N/A | N/A | N/A |
rs876435 | TNFRSF10B | 8 | Wu X, 2009 [36] | A > G | 51/63/33* | 114/148/31* | 2.26 | 1.52 | 3.36 | N/A | N/A | N/A |
rs9562605 | BRCA2 | 13 | Wu X, 2009 [36] | C > T | 107/36/4* | 168/124/6* | 0.54 | 0.37 | 0.78 | N/A | N/A | N/A |
rs9622978 | PDGFB | 22 | Wu X, 2009 [36] | G > T | 49/63/35* | 98/160/35* | 1.92 | 1.3 | 2.85 | N/A | N/A | N/A |
GPX1 ALA | GPX1 | 3 | Jefferies S, 2005 [42] | ALA5/ALA5 | 7 (11.2) | NR | N/A | N/A | N/A | 0.46 | 0.20 | 1.07 |
ALA5/ALA6 | 15 (23.8) | NR | N/A | N/A | N/A | 0.78 | 0.41 | 1.48 | ||||
ALA5/ALA7 | 19 (30.1) | NR | N/A | N/A | N/A | 1.43 | 0.78 | 2.63 | ||||
ALA6/ALA6 | 5 (7.9) | NR | N/A | N/A | N/A | 0.93 | 0.34 | 2.56 | ||||
ALA6/ALA7 | 15 (23.8) | NR | N/A | N/A | N/A | 2.07 | 1.05 | 4.10 | ||||
ALA7/ALA7 | 2 (3.2) | NR | N/A | N/A | N/A | 0.57 | 0.13 | 2.57 |