Table 2 Mean change from baseline in EORTC QLQ-C30 GHS, physical functioning, pain and fatigue and EQ-5D-5L VAS scores up to 36 months by age and ECOG performance status at baseline

  < 75 years

(n = 178)

(n = 193)

(n = 156)

(n = 171)

(n = 143)

(n = 163)

(n = 64)

(n = 115)

(n = 21)

(n = 68)

6.5

10.7

12.4

11.9

13.7

15.2

14.7

14

12.1

16.4

(4.1–8.9)

(8.4–13)

(9.9–15)

(9.4–14.3)

(11.1–16.4)

(12.7–17.7)

(11–18.4)

(11.1–16.9)

(6–18.2)

(12.8–19.9)

  ≥ 75 years

(n = 65)

(n = 69)

(n = 56)

(n = 64)

(n = 42)

(n = 59)

(n = 18)

(n = 37)

(n = 10)

(n = 12)

4.2

5.5

6.2

6.2

9.8

7.5

9.9

3.6

4.4

8.5

(−0.3 to 8.7)

(1–10)

(1.3–11.1)

(1.6–10.8)

(4.2–15.3)

(2.8–12.3)

(2.1–17.8)

(−2.2 to 9.4)

(−6.1 to 15)

(−1.1 to 18.2)

 ECOG performance status 0

(n = 68)

(n = 56)

(n = 57)

(n = 46)

(n = 51)

(n = 51)

(n = 25)

(n = 34)

(n = 11)

(n = 16)

−0.7

8.5

4.8

7.5

1.7

8.5

6

7.4

1.3

10.3

(−4.9 to 3.5)

(3.8–13.1)

(0.3–9.3)

(2.5–12.5)

(−3 to 6.4)

(3.7–13.3)

(−0.5 to 12.5)

(1.7–13.1)

(−8.2 to 10.8)

(2.3–18.3)

 ECOG performance status 1

(n = 123)

(n = 138)

(n = 108)

(n = 126)

(n = 95)

(n = 115)

(n = 38)

(n = 73)

(n = 13)

(n = 43)

5.6

7.8

9.5

8.7

12.2

11.6

11

7.4

9.3

11.8

(2.7–8.6)

(5–10.6)

(6.4–12.7)

(5.8–11.6)

(9–15.5)

(8.6–14.6)

(6.1–15.8)

(3.8–11)

(1.4–17.1)

(7.3–16.3)

 ECOG performance status 2

(n = 54)

(n = 68)

(n = 48)

(n = 63)

(n = 39)

(n = 56)

(n = 20)

(n = 45)

(n = 7)

(n = 21)

11.6

14.7

18

17.9

24.2

21.5

24.2

23.3

19.3

24.7

(6.9–16.3)

(10.5–18.9)

(13.1–23)

(13.6–22.2)

(18.8–29.6)

(17–26)

(17.2–31.3)

(18.4–28.2)

(8.1–30.6)

(18–31.4)

  < 75 years

(n = 178)

(n = 193)

(n = 156)

(n = 171)

(n = 143)

(n = 163)

(n = 64)

(n = 115)

(n = 21)

(n = 68)

8.4

10

12.7

14.1

14.9

17.2

16.8

16.9

14.6

16.9

(6.1–10.7)

(7.7–12.2)

(10.3–15.1)

(11.8–16.4)

(12.5–17.4)

(14.8–19.5)

(13.5–20)

(14.3–19.5)

(9.5–19.8)

(13.7–20)

  ≥ 75 years

(n = 65)

(n = 69)

(n = 56)

(n = 64)

(n = 42)

(n = 59)

(n = 18)

(n = 37)

(n = 10)

(n = 12)

2.9

3

8

4.4

4.1

4.9

5.1

5.9

3.9

3.5

(−2 to 7.9)

(−1.9 to 7.8)

(2.8–13.1)

(−0.5 to 9.4)

(−1.6 to 9.8)

(− 0.2 to 9.9)

(− 2.4 to 12.6)

(0.1–11.7)

(− 5.8 to 13.6)

(− 5.5 to 12.5)

 ECOG performance status 0

(n = 68)

(n = 56)

(n = 57)

(n = 46)

(n = 51)

(n = 51)

(n = 25)

(n = 34)

(n = 11)

(n = 16)

−1.2

2.8

3.1

6.1

2.3

4.6

1.3

2

−0.6

2.4

(−4.5 to 2.1)

(−0.8 to 6.5)

(−0.4 to 6.6)

(2.8–10.4)

(−1.3 to 5.9)

(0.9–8.4)

(−3.3 to 5.9)

(−2.3 to 6.2)

(−7.1 to 5.8)

(−3.2 to 8)

 ECOG performance status 1

(n = 123)

(n = 138)

(n = 108)

(n = 126)

(n = 95)

(n = 115)

(n = 38)

(n = 73)

(n = 13)

(n = 43)

5.2

4.6

9.5

7.3

8.7

11

13.6

10.1

9.9

8.5

(2.1–8.3)

(1.7–7.6)

(6.3–12.7)

(4.3–10.3)

(5.3–12)

(7.9–14.1)

(9–18.2)

(6.6–13.7)

(2.8–16.9)

(4.2–12.7)

 ECOG performance status 2

(n = 54)

(n = 68)

(n = 48)

(n = 63)

(n = 39)

(n = 56)

(n = 20)

(n = 45)

(n = 7)

(n = 21)

16.8

21.4

22.4

26.5

29.3

29.4

27.1

33.4

27.9

35.3

(11.3–22.3)

(16.5–26.2)

(16.7–28.1)

(21.6–31.5)

(23.3–35.3)

(24.3–34.6)

(19.8–34.4)

(28–38.8)

(17.1–38.8)

(28.4–42.1)

  < 75 years

(n = 178)

(n = 193)

(n = 156)

(n = 171)

(n = 143)

(n = 163)

(n = 64)

(n = 115)

(n = 21)

(n = 68)

−12.9

−16.4

−22.1

−20.2

−21.8

−21.7

−24.8

− 23.3

−26.4

− 27

(− 16 to − 9.9)

(− 19.3 to − 13.4)

(−25.3 to − 18.8)

(−23.3 to − 17.1)

(− 25.2 to − 18.5)

(− 24.8 to − 18.5)

(− 29.5 to − 20.1)

(− 26.9 to − 19.7)

(−34.1 to − 18.8)

(− 31.5 to − 22.6)

  ≥ 75 years

(n = 65)

(n = 69)

(n = 56)

(n = 64)

(n = 42)

(n = 59)

(n = 18)

(n = 37)

(n = 10)

(n = 12)

−9.6

− 12.4

− 14.1

− 13.7

−13.2

− 14.5

− 14.3

−8.1

− 8.8

− 17.9

(− 15.4 to − 3.8)

(− 18.2 to − 6.7)

(− 20.3 to − 7.8)

(− 19.6 to − 7.8)

(− 20.2 to − 6.1)

(− 20.6 to − 8.4)

(− 24.4 to − 4.3)

(− 15.5 to − 0.7)

(− 22.3 to 4.7)

(− 30.3 to − 5.6)

 ECOG performance status 0

(n = 68)

(n = 56)

(n = 57)

(n = 46)

(n = 51)

(n = 51)

(n = 25)

(n = 34)

(n = 11)

(n = 16)

− 1.6

− 0.7

− 10

− 7.3

− 6.5

− 5.2

− 9.5

−8.5

− 11.7

− 12.8

(− 6.3 to 3)

(− 5.9 to 4.4)

(− 15.1 to − 5)

(− 12.9 to − 1.7)

(− 11.7 to − 1.2)

(− 10.6 to 0.1)

(− 16.7 to − 2.3)

(− 14.8 to − 2.1)

(− 22.2 to − 1.2)

(− 21.6 to − 3.9)

 ECOG performance status 1

(n = 123)

(n = 138)

(n = 108)

(n = 126)

(n = 95)

(n = 115)

(n = 38)

(n = 73)

(n = 13)

(n = 43)

− 9.6

− 15.5

− 18.8

− 16.6

− 16.3

− 18.6

−19

− 16.2

− 14.8

− 23

(− 13.6 to − 5.6)

(− 19.2 to − 11.7)

(− 23 to − 14.6)

(− 20.5 to − 12.7)

(− 20.7 to − 11.9)

(− 22.6 to − 14.5)

(− 25.4 to − 12.5)

(− 21 to − 11.3)

(− 25.3 to − 4.4)

(− 29.1 to − 17)

 ECOG performance status 2

(n = 54)

(n = 68)

(n = 48)

(n = 63)

(n = 39)

(n = 56)

(n = 20)

(n = 45)

(n = 7)

(n = 21)

− 26.6

− 29

− 31.4

− 33.5

− 40

− 36.4

− 40.8

− 36.4

− 41.1

− 39.9

(−32.7 to − 20.4)

(− 34.5 to − 23.5)

(− 37.9 to − 24.9)

(− 39.2 to − 27.9)

(− 47.1 to − 33)

(− 42.3 to − 30.5)

(− 50 to − 31.6)

(− 42.8 to − 29.9)

(− 55.8 to − 26.5)

(− 48.7 to − 31.1)

  < 75 years

(n = 178)

(n = 193)

(n = 156)

(n = 171)

(n = 143)

(n = 163)

(n = 64)

(n = 115)

(n = 21)

(n = 68)

−7.3

− 7.5

−12.9

− 13.5

−14.1

− 14.9

− 13.6

−13.2

− 12.3

−14.7

(− 9.9 to − 4.7)

(− 10.1 to − 5)

(− 15.7 to − 10.2)

(− 16.1 to − 10.9)

(− 16.9 to − 11.2)

(− 17.6 to − 12.2)

(− 17.5 to − 9.7)

(− 16.2 to − 10.1)

(− 18.6 to − 5.9)

(− 18.5 to − 11)

  ≥ 75 years

(n = 65)

(n = 69)

(n = 56)

(n = 64)

(n = 42)

(n = 59)

(n = 18)

(n = 37)

(n = 10)

(n = 12)

0

0

−4.3

− 3.1

− 4.7

− 4.8

−1.5

− 0.6

− 2.2

− 2.9

(− 5 to 5)

(− 4.8 to 4.9)

(− 9.6 to 0.9)

(− 8.1 to 1.9)

(− 10.6 to 1.3)

(− 10 to 0.4)

(− 9.7 to 6.7)

(− 6.7 to 5.6)

(− 13 to 8.6)

(− 12.8 to 7)

 ECOG performance status 0

(n = 68)

(n = 56)

(n = 57)

(n = 46)

(n = 51)

(n = 51)

(n = 25)

(n = 34)

(n = 11)

(n = 16)

5.5

−2.1

−2.9

− 6.3

− 0.7

− 6

1

− 3.8

−1.2

− 0.9

(1.2–9.9)

(− 6.9 to 2.7)

(−7.5 to 1.7)

(− 11.4 to − 1.2)

(− 5.4 to 4)

(− 11 to − 1.1)

(− 5.1 to 7.1)

(−9.4 to 1.8)

(− 9.7 to 7.3)

(−8.3 to 6.5)

 ECOG performance status 1

(n = 123)

(n = 138)

(n = 108)

(n = 126)

(n = 95)

(n = 115)

(n = 38)

(n = 73)

(n = 13)

(n = 43)

− 5.6

− 5.3

− 11.4

−8.7

− 11.1

− 10.8

− 8.9

−8.3

− 7.4

− 11.1

(− 8.9 to − 2.2)

(− 8.5 to − 2.2)

(− 14.9 to − 7.9)

(− 12 to − 5.5)

(− 14.8 to − 7.4)

(− 14.2 to − 7.5)

(− 14.2 to − 3.7)

(− 12.3 to − 4.4)

(− 15.9 to 1)

(− 16 to − 6.2)

 ECOG performance status 2

(n = 54)

(n = 68)

(n = 48)

(n = 63)

(n = 39)

(n = 56)

(n = 20)

(n = 45)

(n = 7)

(n = 21)

− 15

− 10.2

− 15.4

− 20

− 23.7

− 21.7

− 25

− 19.5

− 19.5

− 23.7

(− 20.3 to − 9.7)

(− 14.9 to − 5.5)

(− 20.9 to − 9.8)

(− 24.8 to − 15.1)

(− 29.7 to − 17.8)

(− 26.8 to − 16.7)

(− 32.8 to − 17.3)

(− 25 to − 14.1)

(− 31.7 to − 7.4)

(− 31.1 to − 16.4)

  < 75 years

(n = 178)

(n = 193)

(n = 156)

(n = 171)

(n = 143)

(n = 163)

(n = 64)

(n = 115)

(n = 21)

(n = 68)

6.8

9.7

9.7

10.9

12.8

12.5

15.3

13.2

13.9

15.6

(4.7–8.8)

(7.7–11.6)

(7.5–11.8)

(8.8–12.9)

(10.6–15)

(10.4–14.6)

(12.2–18.3)

(10.8–15.6)

(9–18.9)

(12.7–18.6)

  ≥ 75 years

(n = 65)

(n = 69)

(n = 56)

(n = 64)

(n = 42)

(n = 59)

(n = 18)

(n = 37)

(n = 10)

(n = 12)

2

5.7

4.5

6

8.1

2.9

3.4

5.1

3.8

2.6

(−1.9 to 5.9)

(1.9–9.5)

(0.3–8.6)

(2.1–9.9)

(3.5–12.8)

(−1.1 to 6.9)

(−3.1 to 10)

(0.3–9.8)

(−4.7 to 12.3)

(− 5.1 to 10.4)

 ECOG performance status 0

(n = 68)

(n = 56)

(n = 57)

(n = 46)

(n = 51)

(n = 51)

(n = 25)

(n = 34)

(n = 11)

(n = 16)

− 0.5

6.8

2.6

7.9

4.4

4

5.4

6

1.4

4.9

(−3.7 to 2.7)

(3.3–10.3)

(−0.9 to 6)

(4.1–11.8)

(0.9–8)

(0.4–7.7)

(0.6–10.3)

(1.7–10.3)

(−5.5 to 8.2)

(−0.9 to 10.8)

 ECOG performance status 1

(n = 123)

(n = 138)

(n = 108)

(n = 126)

(n = 95)

(n = 115)

(n = 38)

(n = 73)

(n = 13)

(n = 43)

5.1

6.8

6.8

6.7

10.7

8.5

10.4

7.4

11.8

10.1

(2.4–7.7)

(4.3–9.3)

(4–9.6)

(4.1–9.3)

(7.8–13.6)

(5.9–11.2)

(6.2–14.6)

(4.3–10.6)

(5–18.5)

(6.2–14.1)

 ECOG performance status 2

(n = 54)

(n = 68)

(n = 48)

(n = 63)

(n = 39)

(n = 56)

(n = 20)

(n = 45)

(n = 7)

(n = 21)

11.4

15.2

16.3

18.5

20

19.2

22.8

23.3

20.3

26.1

(7.6–15.3)

(11.7–18.7)

(12.2–20.4)

(15–22.1)

(15.6–24.4)

(15.5–22.9)

(17.1–28.5)

(19.3–27.3)

(11.3–29.2)

(20.7–31.5)