Evaluation of functional outcome of bilateral kidney tumors after sequential surgery

BMC Cancer

Table 6 Multivariate Cox regression analyses of variables associated with de novo CKD during the entire follow-up period

	Univariate analysis			Multivariate analysis
	HR	95% CI	P value	HR	95% CI	P value
Age (years)	1.031	1.009–1.053	0.005	1.005	0.971–1.040	0.780
BMI	1.029	0.946–1.120	0.500
Sex, male	0.607	0.306–1.205	0.154
DM	1.530	0.806–2.905	0.194
HTN	1.956	1.147–3.335	0.014	1.905	1.172–3.265	0.010
Baseline eGFR	0.992	0.982–1.002	0.106
Baseline Hb	1.002	0.902–1.114	0.969
EBL (1st surgery)	1.000	0.999–1.000	0.784
EBL (2nd surgery)	1.000	0.999–1.001	0.680
Ischemic time (1st surgery)	1.001	0.972–1.032	0.921
Ischemic time (2nd surgery)	0.985	0.956–1.014	0.301
Pathologic tumor size (1st surgery)	1.016	1.007–1.025	0.001	1.013	1.000–1.027	0.051
Pathologic tumor size (2nd surgery)	1.004	0.997–1.011	0.278
Time between operations	1.000	1.000–1.001	0.056
Surgery sequence
PN ➔ PN	Reference			Reference
PN ➔ RN	2.919	1.386–6.146	0.001	1.888	1.088–4.055	< 0.001
RN ➔ PN	2.190	1.165–4.114	0.015	1.041	1.003–3.258	0.103
PN (unilateral case)	0.782	0.366–1.669	0.525	0.233	0.088–0.614	0.718
Tumor chronology
Synchronous	Reference			Reference
Metachronous	2.250	1.121–4.516	0.023	2.682	1.032–6.973	0.043
Tumor multiplicity
Unilateral	Reference
Bilateral	1.421	0.824–2.449	0.206

ISSN: 1471-2407