Skip to main content

Table 4 Univariate and multivariate analyses of factors for progression-free survival using cox regression model (N = 16)

From: Association of emergence of new mutations in circulating tumuor DNA during chemotherapy with clinical outcome in metastatic colorectal cancer

  Univariate analysis Multivariable analysis
HR 95.0% CI P value HR 95.0% CI P value
Age 1.0050 0.9534–1.0593 0.8539 1.0787 0.9595–1.2128 0.2048
Gender 1.0956 0.2897–4.1431 0.8930 784.8123 2.8072–219,412.9720 0.0204
ECOG 0.7963 0.4319–1.4681 0.4655 4.9876 1.0327–24.0880 0.0455
Location 1.0421 0.2696–4.0276 0.9523 11.4735 0.1187–1108.9594 0.2955
Synchronicity 2.9627 0.8893–9.8702 0.0769 54.3070 1.1487–2567.3704 0.0423
Baseline CEA 1.0000 0.9992–1.0007 0.9190 1.0003 0.9983–1.0024 0.7363
Baseline mTBI 1.0236 1.0001–1.0476 0.0494 1.1574 1.0381–1.2903 0.0084
New mutations 0.0486 0.0052–0.4540 0.0080 0.0006 0.0000–0.0831 0.0033
  1. ECOG Eastern Cooperative Oncology Group performance status, CEA carcinoembryonic antigen, mTBI molecular tumour burden index