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Table 4 Univariate and multivariate analyses of factors for progression-free survival using cox regression model (N = 16)

From: Association of emergence of new mutations in circulating tumuor DNA during chemotherapy with clinical outcome in metastatic colorectal cancer

 

Univariate analysis

Multivariable analysis

HR

95.0% CI

P value

HR

95.0% CI

P value

Age

1.0050

0.9534–1.0593

0.8539

1.0787

0.9595–1.2128

0.2048

Gender

1.0956

0.2897–4.1431

0.8930

784.8123

2.8072–219,412.9720

0.0204

ECOG

0.7963

0.4319–1.4681

0.4655

4.9876

1.0327–24.0880

0.0455

Location

1.0421

0.2696–4.0276

0.9523

11.4735

0.1187–1108.9594

0.2955

Synchronicity

2.9627

0.8893–9.8702

0.0769

54.3070

1.1487–2567.3704

0.0423

Baseline CEA

1.0000

0.9992–1.0007

0.9190

1.0003

0.9983–1.0024

0.7363

Baseline mTBI

1.0236

1.0001–1.0476

0.0494

1.1574

1.0381–1.2903

0.0084

New mutations

0.0486

0.0052–0.4540

0.0080

0.0006

0.0000–0.0831

0.0033

  1. ECOG Eastern Cooperative Oncology Group performance status, CEA carcinoembryonic antigen, mTBI molecular tumour burden index