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Table 1 Patient characteristics and association with baseline mTBI (N = 20)

From: Association of emergence of new mutations in circulating tumuor DNA during chemotherapy with clinical outcome in metastatic colorectal cancer

Characteristic

N (%)

Baseline mTBI (%)

Median (IQR)

P Value

All patients

20

  

Age (years), median

60 (34–76)

  

Age group

 < 60

11 (55.0)

3.62 (0.90–27.54)

–

 60+

9 (45.0)

23.79 (4.11–48.52)

0.2601

Gender

 Female

6 (30.0)

3.24 (0.00–4.11)

–

 Male

14 (70.0)

38.72 (6.80–57.99)

0.0111

ECOG

 0

15 (75.0)

5.00 (1.24–38.72)

–

 1

5 (25.0)

45.52 (6.37–73.77)

0.0978

Primary tumor site

 Left-side colon

16 (80.0)

9.01 (1.38–44.57)

–

 Right-side colon

4 (20.0)

13.71 (3.34–60.85)

0.8198

Synchronicity of metastasis

 Metachrone

10 (50.0)

12.49 (1.65–45.9)

–

 Synchrone

10 (50.0)

7.20 (2.43–46.3)

1.0000

Primary tumor(s)

 Resected

15 (75.0)

5.00 (1.79–38.72)

–

 Unresected

5 (25.0)

41.70 (4.70–59.36)

0.3941

Metastatic site(s)

 1 without peritoneum

9 (45.0)

9.40 (2.24–47.02)

–

 2+ without peritoneum

11 (55.0)

8.62 (1.79–38.72)

0.8817

 Peritoneum

0

 

–

Baseline serum CEA

 Normal

5 (25.0)

1.79 (0.62–13.52)

–

 Elevated

15 (75.0)

16.36 (4.11–48.52)

0.0522

Chemotherapy regimen

 FOLFOX

15 (75.0)

8.62 (3.24–45.52)

–

 FOLFIRI

5 (25.0)

16.36 (1.52–51.94)

0.9327

Bevacizumab received

 Yes

1 (5.0)

23.79

–

 No

19 (95.0)

8.62 (1.79–45.52)

–

  1. P value indicates a significance level of < 0.05
  2. IQR interquartile range, ECOG Eastern Cooperative Oncology Group performance status, CEA carcinoembryonic antigen