Table 1 Model Parameters

Starting Age

60

13,23

Dose SSA

Octreotide LAR 20 mg/28 days

Octreotide 60 mg with PRRT

38–40

 Cost SSA

$4121/month for Octreotide

$2060–$8242

28

 Cost PRRT

$205,200

$102,600-410,400

31,41

 Rate of Complications from SSA

1% over 96 weeks

+/− 25%

13,23

 All cause mortality

CDC Life Tables

32

 Rate of NET related death, untreated

18 month median survival

+/−25%

25,33

 Rate of NET related death, on SSA

39 month median survival

+/−25%

25,33

 Rate of NET related death, on PRRT

39 month median survival

+/−25%

37,42

 Rate of progression, off SSA

6 month median

+/−25%

13,23

 Rate of progression, on SSA

14 month median

+/−25%

13,23

 Rate of progression after delaying initiation of SSA

14 month median

+/−25%

24,37

 Quality of Life pre SSA

0.79

+/−0.1

34,35,43

 Quality of Life on SSA

0.79

+/−0.1

34,43

 Quality of Life with disease progression

0.72

+/−0.1

34

 Quality of Life with uncontrolled symptoms

0.32

+/−0.1

36,44