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Fig. 5 | BMC Cancer

Fig. 5

From: Long non-coding RNA BRE-AS1 inhibits the proliferation, migration, and invasion of cancer cells in triple-negative breast cancer and predicts patients’ survival by downregulating miR-21

Fig. 5

Overexpression of lncRNA BRE-AS1 inhibits TNBC cell proliferation and apoptosis of TNBC cells through miR-21. CCK-8 assay (a), Colony Formation Assay (b) and Cell cycle and apoptosis assay (c) were perfrmed to study the roles of BRE-AS1and miR-21 in the regulation of TNBC cell proliferation and apoptosis. BRE-AS1 decreased, while o miR-21 increaed the proliferation of cells of TNBC cell lines BT-549 and HCC70. In addition, overexpression of miR-21 attenuated the inhibitory effects of overexpression of lncRNA BRE-AS1 on cancer cell proliferation. Western blot analysis showed that overexpression of BRE-AS1 increased the expression levels of tumor suppressor Bax, cleaved-Caspase 3, cleaved-Casepase 9, Ki67 and BCL-2 (d). Data of three independent replicates were expressed as mean ± SD (*, p < 0.05)

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BMC Cancer

ISSN: 1471-2407

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