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Table 2 Cause of death (AML or non-AML) in the main cohort (C1.X to C16.X)

From: The effects of secondary iron overload and iron chelation on a radiation-induced acute myeloid leukemia mouse model

Label Iron/ICTa AFS/OS (weeks)b Final body weight (g) Final liver weight (g) Final spleen weight (mg) Diagnosisc
AML
 C3.3 7.5/0 35.8/37.1 33.5 2.53 260 Monocytic leukemia
 C3.6 7.5/0 54.0/57.0 45.0 Myeloid leukemiad
 C3.7 7.5/0 41.0/43.0 36.3 Myeloid leukemiad
 C4.1 7.5/0 58.7/60.0 47.1 3.83 1085 Monocytic leukemia
 C4.5 7.5/0 25.4/27.7 29.0 2.22 367 Monocytic leukemia
 C10.1 7.5/10 31.3/35.0 31.6 7.29 1560 Monocytic leukemia
 C11.4 7.5/40 37.3/38.3 34.1 3.64 1609 Monocytic leukemia
 C11.5 7.5/40 63.1/69.0 40.7 2.06 86 Myeloid leukemiae
 C12.5 7.5/40 36.3/41.6 36.4 2.01 930 Myelomoncytic leukemia
 C6.1 15/0 55.7/57.0 42.9 3.94 789 Monocytic leukemia
 C6.5 15/0 52.7/54.0 52.2 4.01 579 Myeloid leukemiad
 C7.4 30/0 67.1/67.1 58.9 3.42 548 Myelomoncytic leukemia
 C13.3 30/10 42.1/45.0 36.9 3.80 742 Myeloid leukemiad
 C13.4 30/10 33.3/36.4 33.1 6.01 1170 Monocytic leukemia
 C14.2 30/10 55.6/55.6 41.3 3.32 293 Myeloid leukemiad
Non-AML (censored)
 C1.4 0/0 -−−/56.6 43.9 2.04 97 Other
 C2.4 0/0 -−−/50.0 49.9 2.12 1380 Metastasized tumor
 C4.4 7.5/0 -−−/16.7 37.2 1.46 63 Other
 C10.2 7.5/10 -−−/69.3 51.8 1.78 80 Other
 C10.5 7.5/10 -−−/68.6 45.5 6.30 175 Liver tumor
 C12.1 7.5/40 -−−/69.1 35.6 1.13 140 Lung tumor
 C5.1 15/0 -−−/67.1 52.0 2.88 187 Abdominal tumor
 C7.3 30/0 -−−/52.6 37.3 Other
 C8.5 30/0 -−−/39.6 28.4 2.08 87 Other
 C15.1 30/40 -−−/54.6 38.9 2.71 421 Lymphoid neoplasm
 C15.2 30/40 -−−/31.6 29.2 1.88 89 Liver tumor
 C15.4 30/40 -−−/44.0 60.8 3.87 205 Bone tumor
 C16.2 30/40 -−−/67.4 58.0 3.40 389 Abdominal tumor
  1. a Iron burden (mg) / ICT by deferasirox (mg/kg/d)
  2. b AML-free survival / overall survival (post-irradiation, weeks)
  3. c Diagnosis of AML was made based on the Bethesda proposals for classification of nonlymphoid hematopoietic neoplasms in mice
  4. d AML subtype not determined
  5. e Myeloid leukemia with maturation