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Table 2 Cause of death (AML or non-AML) in the main cohort (C1.X to C16.X)

From: The effects of secondary iron overload and iron chelation on a radiation-induced acute myeloid leukemia mouse model

Label

Iron/ICTa

AFS/OS (weeks)b

Final body weight (g)

Final liver weight (g)

Final spleen weight (mg)

Diagnosisc

AML

 C3.3

7.5/0

35.8/37.1

33.5

2.53

260

Monocytic leukemia

 C3.6

7.5/0

54.0/57.0

45.0

Myeloid leukemiad

 C3.7

7.5/0

41.0/43.0

36.3

Myeloid leukemiad

 C4.1

7.5/0

58.7/60.0

47.1

3.83

1085

Monocytic leukemia

 C4.5

7.5/0

25.4/27.7

29.0

2.22

367

Monocytic leukemia

 C10.1

7.5/10

31.3/35.0

31.6

7.29

1560

Monocytic leukemia

 C11.4

7.5/40

37.3/38.3

34.1

3.64

1609

Monocytic leukemia

 C11.5

7.5/40

63.1/69.0

40.7

2.06

86

Myeloid leukemiae

 C12.5

7.5/40

36.3/41.6

36.4

2.01

930

Myelomoncytic leukemia

 C6.1

15/0

55.7/57.0

42.9

3.94

789

Monocytic leukemia

 C6.5

15/0

52.7/54.0

52.2

4.01

579

Myeloid leukemiad

 C7.4

30/0

67.1/67.1

58.9

3.42

548

Myelomoncytic leukemia

 C13.3

30/10

42.1/45.0

36.9

3.80

742

Myeloid leukemiad

 C13.4

30/10

33.3/36.4

33.1

6.01

1170

Monocytic leukemia

 C14.2

30/10

55.6/55.6

41.3

3.32

293

Myeloid leukemiad

Non-AML (censored)

 C1.4

0/0

-−−/56.6

43.9

2.04

97

Other

 C2.4

0/0

-−−/50.0

49.9

2.12

1380

Metastasized tumor

 C4.4

7.5/0

-−−/16.7

37.2

1.46

63

Other

 C10.2

7.5/10

-−−/69.3

51.8

1.78

80

Other

 C10.5

7.5/10

-−−/68.6

45.5

6.30

175

Liver tumor

 C12.1

7.5/40

-−−/69.1

35.6

1.13

140

Lung tumor

 C5.1

15/0

-−−/67.1

52.0

2.88

187

Abdominal tumor

 C7.3

30/0

-−−/52.6

37.3

Other

 C8.5

30/0

-−−/39.6

28.4

2.08

87

Other

 C15.1

30/40

-−−/54.6

38.9

2.71

421

Lymphoid neoplasm

 C15.2

30/40

-−−/31.6

29.2

1.88

89

Liver tumor

 C15.4

30/40

-−−/44.0

60.8

3.87

205

Bone tumor

 C16.2

30/40

-−−/67.4

58.0

3.40

389

Abdominal tumor

  1. a Iron burden (mg) / ICT by deferasirox (mg/kg/d)
  2. b AML-free survival / overall survival (post-irradiation, weeks)
  3. c Diagnosis of AML was made based on the Bethesda proposals for classification of nonlymphoid hematopoietic neoplasms in mice
  4. d AML subtype not determined
  5. e Myeloid leukemia with maturation