Skip to main content

Table 1 Characteristics of the B6D2F1 mice in the main cohort (C1.X to C16.X)

From: The effects of secondary iron overload and iron chelation on a radiation-induced acute myeloid leukemia mouse model

Treatment (iron/ICT) 0/0 7.5/0 7.5/10 7.5/40 15/0 30/0 30/10 30/40
  C1.XC2.X C3.XC4.X C9.XC10.X C11.XC12.X C5.XC6.X C7.XC8.X C13.XC14.X C15.XC16.X
N 13 13 10 10 10 10 10 10
Total iron burden (mg) 0 7.5 7.5 7.5 15 30 30 30
Deferasirox (mg/kg/d) 0 0 10 40 0 0 10 40
Mean initial body weight (g) 27.12 ± 1.57 28.21 ± 2.1 32.93 ± 2.85 30.51 ± 1.79 27.68 ± 3.32 27.32 ± 1.78 31.19 ± 1.48 31.69 ± 3.11
Mean maximum body weight (g) 52.35 ± 3.37 50.48 ± 7.05 56.37 ± 4.64 50.38 ± 4.13 52.56 ± 6.05 55.91 ± 10.89* 51.95 ± 5.27 56.73 ± 7.52
Mortality due to AML 0 (0%) 5 (38%) 1 (10%) 3 (30%) 2 (20%) 1 (10%) 3 (30%) 0 (0%)
Total mortality 2 (15%) 7 (54%) 3 (30%) 4 (40%) 3 (30%) 3 (30%) 3 (30%) 4 (40%)
  1. * F-test compared to control P < 0.0005