Table 5 Multivariate analysis of factors associated with disease-free survival in patients with Siewert type II/III AEG
Variable | Training cohort (n = 203) | Validation-1 cohort (n = 88) | Validation-2 cohort (n = 105) | |||
|---|---|---|---|---|---|---|
HR (95%CI) | P | HR (95%CI) | P | HR (95%CI) | P | |
Blood transfusion (vs. No) | NA | Â | NA | Â | NA | Â |
Organ invasion (vs. Absence) | 1.612 (1.074–2.422) | 0.021 | NA |  | NA |  |
Serosal infiltration (vs. S0) | NA |  | NA |  | 1.894 (1.348–2.660) | < 0.001 |
Borrmann type (vs. I) | NA | Â | NA | Â | NA | Â |
pTNM stage (vs. I-II) | NA | Â | NA | Â | NA | Â |
Grade of differentiation (vs. Well) | NA | Â | NA | Â | NA | Â |
PLNa | NA |  | NA |  | 1.058 (1.032–1.085) | < 0.001 |
LNRa | NA | Â | NA | Â | NA | Â |
LODDSa | 1.408 (1.265–1.568) | < 0.001 | 1.558 (1.249–1.944) | < 0.001 | NA |  |
PLT (vs. < 229) | NA |  | 0.458 (0.236–0.889) | 0.021 | NA |  |
ALB (vs. < 39.4) | NA |  | NA |  | NA |  |
CA-125 (vs. < 9.70) | NA |  | NA |  | NA |  |